Polyvalent drug allergy or hypersensitivity to macrogol?

Article describes a clinical observation of an 83-year-old patient who applied to the Center for clinical pharmacology and pharmacotherapy in Stavropol with complaints of intense pruritus and periodically arising papular eruptions on thighs, forearms, back, and chest that had been occurring for the past 2–3 years. Laboratory studies revealed mechanisms of hypersensitivity to all medications he was taking as part of ongoing treatment for concomitant diseases. Macrogol (polyethylene glycol) was a common component (as an excipient) in all of these medications. After adjusting his medication therapy, the patient noted an improvement in his condition, including a gradual decrease in the intensity of itching and the number of rashes on his forearms and chest. This clinical case highlights the need for clinicians to carefully consider the appropriate pharmacotherapy for elderly patients, taking into account their individual allergic reactivity to medications.