Патогенетическая терапия легочной гипертензии

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Аннотация

Легочная гипертензия (ЛГ) – гемодинамическое и патофизиологическое состояние, которое характеризуется повышением среднего давления в легочной артерии ≥20 мм рт.ст. в покое, измеренного при катетеризации правых отделов сердца. Во всем мире принципиально выделяют 5 основных групп ЛГ. Наиболее изученной с точки зрения подбора оптимальной патогенетической терапии является идиопатическая легочная артериальная гипертензия (ИЛАГ), относящаяся к 1-й группе по классификации ЛГ 2018 г. Ключевым звеном в патогенезе ЛГ выступает дисбаланс основных вазодилатирующих (например, монооксида азота, простациклина) и вазоконстрикторных субстанций (эндотелина-1, тромбоксана А2, серотонина) с преобладанием последних. Учитывая сложность патогенеза, пациентам с легочной артериальной гипертензией требуется многогранный, целостный и междисциплинарный подход. Предлагаемая статья посвящена обзору лекарственных средств для лечения ЛГ, а также стратегии их назначения.

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Наталья Анатольевна Царева

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)

Автор, ответственный за переписку.
Email: n_tsareva@mail.ru
ORCID iD: 0000-0001-9357-4924

к.м.н., доцент кафедры пульмонологии 

Россия, 119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

Михаил Викторович Хачатуров

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)

Email: khachaturov.michael@gmail.com
ORCID iD: 0000-0001-7606-6565

студент 5 курса 

Россия, 119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

Сергей Николаевич Авдеев

ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)

Email: serg_avdeev@list.ru
ORCID iD: 0000-0002-5999-2150

д.м.н., профессор, академик РАН, проректор по научной работе, зав. кафедрой пульмонологии 

Россия, 119991, г. Москва, ул. Трубецкая, д. 8, стр. 2

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