Применение ацетилсалициловой кислоты и ее комбинированных форм в реальной клинической практике

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Аннотация

Первое упоминание о возможности первичной профилактики инфаркта миокарда производным салицина – ацетилсалициловой кислотой (АСК) – было опубликовано еще в 1950 г. В этом специализированном обзоре представлена обновленная информация о роли АСК в первичной и вторичной профилактике сердечно-сосудистых заболеваний, а также некоторые сведения о том, в каком направлении может развиваться эта профилактика.

Цель обзора – осветить роль АСК в современной реальной клинической практике терапевта.

Материал и методы. Предложен адаптивный вариант литературного поиска, когда он осуществляется по каждому разделу обзора отдельно. В базах данных PubMed (MEDLINE), Scopus, eLibrary и Киберленинка делались поисковые запросы по следующим группам ключевых слов: *acetylsalicylic acid, *aspirin, *mechanism of action, *pharmacokinetics, *pharmacodynamics, *placebo-controlled studies, *efficiency, *safety, *combined forms, *magnesium hydroxide. В русскоязычных базах данных запрос составлялся по такому же алгоритму с использованием аналогичных терминов на русском языке. В обзор литературы вошел 61 источник.

Заключение. Учитывая большой объем доказательств эффективности и безопасности, АСК в низких дозах должна продолжать использоваться в качестве антитромботического средства для профилактики сердечно-сосудистой смертности. В современной клинической практике она вряд ли будет вытеснена доступными в настоящее время ингибиторами P2Y12 из-за неубедительной демонстрации их превосходства над АСК в низких дозах.

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Алексей Михайлович Борисов

ФГБУ «Национальный медицинский исследовательский центр травматологии и ортопедии им. Р.Р. Вредена» Минздрава России

Email: amborisov@rniito.ru
ORCID iD: 0000-0003-3449-8196
SPIN-код: 2928-4410

врач – клинический фармаколог отделения клинической фармакологии

Россия, Санкт-Петербург

Алина Рашидовна Касимова

ФГБУ «Национальный медицинский исследовательский центр травматологии и ортопедии им. Р.Р. Вредена» Минздрава России; ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Минздрава России

Автор, ответственный за переписку.
Email: kasi-alina@yandex.ru
ORCID iD: 0000-0001-6284-7133
SPIN-код: 3131-4385

к. м. н., доцент, доцент кафедры клинической фармакологии и доказательной медицины, клинический фармаколог отделения клинической фармакологии

Россия, Санкт-Петербург; Санкт-Петербург

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