Diagnostic and prognostic significance of endothelial dysfunction biochemical markers in patients with discirculatory encephalopathy after COVID-19

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Cerebrovascular diseases and COVID-19 are comorbid conditions. Endothelial dysfunction is one of the pathogenetic mechanisms for cerebrovascular diseases and COVID-19 development. Laboratory feature of endothelial dysfunction is a change in the level of endothelial dysfunction biochemical markers in the blood serum of patients.

The aim: to study the diagnostic and prognostic value of biochemical markers of endothelial dysfunction in patients with dyscirculatory encephalopathy (DE) who underwent COVID-19.

Material and methods. For the period from 03/01/22 to 05/31/22, 172 patients were examined, including 137 (79,6%) female and 35 (20.4%) male patients who had COVID-19 and are being examined at the base polyclinic No. 2 of the Central clinical medical and sanitary unit named after honored doctor of Russia V.A. Egorov, Ulyanovsk. Median time from the onset of COVID-19 to examination was 4.8 months. DE was not found in 6% of patients who underwent COVID-19, stage I DE was present in 45%, stage II in 27%, stage III in 22% of participants of the study. Blood sampling was carried out once during the all examination period. Levels of vasculoendothelial growth factor (VEGFA), interleukins 6, 10, 18, tumor necrosis factor-alpha, and monocytic chemotactic protein 1 were studied in blood serum. The Mann–Whitney U-test was used to test the hypothesis of a difference in the samples of patient groups. For all types of statistical analysis, differences were considered to be significant at the achieved significance level p <0,05.

Results. According to our research, with an increase of the age of patients who have undergone COVID-19, and the DE stage the level of VEGFA in serum was also increasing (p <0,05).

Conclusion. From studied cytokines, the predictive role as a marker of endothelial dysfunction was shown by VEGFA. Its high level in blood serum is associated with the age of DE patients, who have undergone COVID-19, and with the stage of DE they had.

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作者简介

Viktor Mashin

Ulyanovsk State University

编辑信件的主要联系方式.
Email: victor_mashin@mail.ru
ORCID iD: 0000-0003-0085-3727

MD, Professor, Head of the Department of Neurology, Neurosurgery and Medical Rehabilitation

俄罗斯联邦, Ulyanovsk

Dinara Dolgova

Ulyanovsk State University

Email: dolgova.dinara@yandex.ru
ORCID iD: 0000-0001-5475-7031

PhD in Biological Sciences, Associate Professor of the Department of Physiology and Pathophysiology, Director of Scientific Research Physicobiological Center

俄罗斯联邦, Ulyanovsk

Lyudmila Belova

Ulyanovsk State University

Email: labelova@mail.ru
ORCID iD: 0000-0002-9585-5604

MD, Professor, Dean of the Faculty of Medicine of the Institute of Medicine, Ecology and Physical Culture

俄罗斯联邦, Ulyanovsk

Elena Kotova

Ulyanovsk State University

Email: ko-tovatv@mail.ru
ORCID iD: 0009-0004-2293-3183

PhD in Medical Sciences, Associate Professor of the Department of Neurology, Neurosurgery and Medical Rehabilitation

俄罗斯联邦, Ulyanovsk

Landysh Kruglova

Ulyanovsk State University

Email: lali.04@bk.ru
ORCID iD: 0009-0008-9665-6915

Postgraduate Student of the Department of Neurology, Neurosurgery and Medical Rehabilitation

俄罗斯联邦, Ulyanovsk

Anastasia Statenina

Ulyanovsk State University

Email: nastya.statenina@mail.ru

student of the Faculty of Medicine named after T.Z. Biktimirov of the Institute of Medicine, Ecology and Physical Culture (group LD-O-19/3)

俄罗斯联邦, Ulyanovsk

Andrey Kozin

Ulyanovsk State University

Email: supervaclove@gmail.ru

student of the Faculty of Medicine named after T.Z. Biktimirov of the Institute of Medicine, Ecology and Physical Culture (group LD-O-17/6)

俄罗斯联邦, Ulyanovsk

Rumiya Israfilova

Ulyanovsk State University

Email: israfilovarr@gmail.ru

student of the Faculty of Medicine named after T.Z. Biktimirov of the Institute of Medicine, Ecology and Physical Culture (group LD-O-18/9)

俄罗斯联邦, Ulyanovsk

Daria Martynova

Ulyanovsk State University

Email: martynova.daria2000@yandex.ru

student of the Faculty of Medicine named after T.Z. Biktimirov of the Institute of Medicine, Ecology and Physical Culture (group LD-O-18/11)

俄罗斯联邦, Ulyanovsk

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