Vol 3, No 2 (2018)

Aim - to show the possibilities of diagnostics with the use of VERION Measurement Module, followed by personalized drawing up an operation plan on the analytical module "VERION Vision Planner" and the calculation of high-tech IOLs. The evaluation of the work of the navigation system "VERION Digital Marker Microscope" in high-tech cataract surgery and presbyopia. Materials and methods. The results of the prospective open study of phacoemulsification of cataract and refractive lens surgery with implantation of high-tech intraocular lenses of Alcon company (USA) were studied. The calculation of the optical power of the IOL was performed using a navigation system, "VERION" (Alcon). Functional and refractive data before and after surgery were evaluated. Results. High-tech IOL implanted 100 patients (180 eyes). Sphericules clinical refraction was -0,15±0,28 diopters. Refraction of the target (em±0,5 DPT) was achieved in all patients. Intraoperative and postoperative complications were not observed. In all patients, the obtained refractive effect practically coincided with the potentially expected one. All patients are satisfied with the results of the operation and the choice of intraocular lens. Conclusion. 1. Diagnostic analytical module "VERION Reference Unit" of "VERION" system allows accurately selecting of the optical power of high-tech IOLs and their toric component with the preparation of the individual operation plan for each patient. 2. Navigation system "VERION Digital Marker Microscope" allows to carry out high-tech surgery of cataract and presbyopia according to the developed plan of operation. Deviation of the spherical refraction component obtained in the postoperative period from the expected, according to "VERION Vision Planner", was 0.2+0.15 DPTR; deviation of the cylindrical refraction component was 0.3+0.26 DPTR.

This article is devoted to the problems of residual risk of cardiovascu1ar comp1ications deve1opment for high and very high risk patients under adequate lipid-fowering pharmacotherapy in spite of c^lestera! and tow-density 1ipoproteins target level achievement. Afong with classic risk factors the special atte^ton is given to 1ipoprotein (a) [LP (a)] as the most aggressive factor of cardwvascular system atherosclerotic diseases devetopment and their comp1ications. Great importance is attached to 1ipidopheresis.

Aims - to analyze the historical aspects of the formation of the national normative framework in the field of primary and periodic medical examinations, to discuss the existing problems in the carrying out of primary and periodic medical examinations of workers and also to make suggestions for quality improvement of primary and periodic medical examinations and for introduction of occupational risk assessment into the practice of primary and periodic medical examinations. Conclusion. For quality improvement of primary and periodic medical examinations, for efficiency improvement of primary and secondary prevention of occupational diseases it is considered to be necessary to take the following suggestions: - fuller coverage of working people by periodic medical examinations; - thorough selection of organizations that perform the special assessment of working conditions; - the use of the results of the special assessment of working conditions for improving working conditions and informing workers about working conditions; - implementation of occupational risk assessment into practice of primary and periodic medical examinations; - the use of modern methods of molecular and genetic screening;

Aim - to identify the most significant risk factors that affect the occurrence of cardiovascular complications in patients with type 2 diabetes and to create the supplement for the risk assessment of cardiovascular complications in patients with type 2 diabetes. Methods of research. The object of the study is adult patients with type 2 diabetes mellitus (n = 60). For the development and analysis of the material, a statistical method is used, a modeling method of constructing the classification trees. Discussion and results. Statistically significant risk factors for cardiovascular complications in type 2 diabetes are a high body mass index, the presence of insulin therapy, the duration of the disease, a high maximum level of systolic blood pressure, high concentrations of LDL, markers of cell damage, and some hemodynamic parameters of myocardial function. A multidimensional model of the risk of complications was developed, which served as an algorithm for the created computer program, their early prognosis and timely carrying out of preventive measures.

Aim - determination of RFTA place in the combined treatment of bilobar liver metastatic process of colorectal cancer. Materials and methods. 176 patients with colorectal cancer with multiple (more than 4) bilobar liver metastases were included in the study after primary tumor removal. The research was held in Samara Regional Oncology Centre from 2001 to 2014. According to the treatment method patients were divided into two groups. Main group got the combined (chemotherapy + RFTA) treatment (98 patients). In control group only chemotherapy was applied to 78 patients. Results. One-, two- and three-year OS were 73.5%, 25.1%, 7.2% in the main group and 39.6%, 6.3%, 2.1% in the control group. With RFTA application we reached the 1.8% index of four-year survival in the main group, while three-year survival in the control group was only 2.1%. The OS median reached 18 months in the main group and 11 months in the control group, OS curves in two comparing groups were significantly different( log-rank test 3.77, р=0,000). Conclusion. Combination of RFTA with chemotherapy as the treatment of bilobar liver metastases of colorectal cancer, significantly improves the DFS and overall survival indexes, comparing to the group of patients who received only chemotherapy.

Introduction. Inflammatory myofibroblastic tumor (IMT) is a rare form of children neoplasm, characterized by intermediate biological behavior. In case of this, pathological diagnostics and valid tumor prognosis are difficult to perform; practitioners are not familiar enough with this pathology. Aim - to get an idea of the tumor morphological features, approaches to differential diagnosis of IMT, spreading in pediatric oncopathology, based on a review of modern literature. Material and methods. The retrospective analysis of soft tissue tumors in children operated for the period from 2007 to 2017 in Samara City Children's Clinical Hospital №1 n.a. Ivanova N.N. was performed. Among 1344 tumors, 5 cases verified as were detected IMT Results. Own clinical observations with children’s sex and age, tumor localization and speed of development, results of surgical treatment, tumor description in gross and in histological specimens, results of additional methods used in differential diagnostics from sarcomas are presented. Conclusions. Taking into account the tendency of tumor recurrence, the conclusion of the importance of morphological study of margins of tumor resection is made.

Aim - to prove the necessity of including the methods, which normalize the vascular and intravascular component of the hemostasis system, in the combined therapy of inflammatory periodontal diseases, as the microcirculation disorders play the most important role in the pathogenesis of inflammatory periodontal diseases and correlates with severity level. Materials and methods. In order to study the possibility to correct the malformation of the adhesive and aggregation activity of the blood platelets in patients with inflammatory periodontal diseases, we carried out a study of the adhesion and aggregation of platelets after a course of combined therapy, which included combined effects of laser and EHF radiation. The most important link in restoration of microcirculation is the vasoregulative effect of laser irradiation. Results. There is a partial or complete restoration of aggregation and adhesive activity of the blood platelets. Conclusion. The use of combined laser and EHF radiation of the “Matrix” equipment allows stopping the inflammation of the tissues quickly. Correction of these disorders by non-drug methods, in comparison with a medication-assisted treatment, has no side effects, and can be recommended as a component of combined therapy in patients with inflammatory periodontal diseases.