Clinical nutrition and metabolismClinical nutrition and metabolismКлиническое питание и метаболизм2658-44332782-2974Eco-Vector2077810.17816/clinutr20778ReviewsНаучные обзорыResearch ArticleGlutamine and its derivatives in the correction of metabolic disorders in HIV-infected patients (review)Глутамин и его производные в коррекции метаболических нарушений у ВИЧ-инфицированных пациентов (научный обзор)2003-5693LuftValery V.ЛуфтВалерий Матвеевич
Russian Federation

д.м.н., профессор, руководитель лаборатории клинического питания

Lvm_aspep@mail.ruDmitrievAlexander V.ДмитриевАлександр Владимирович
Russian Federation

д.м.н., клинический фармаколог, эксперт Северо-Западной ассоциации парентерального и энтерального питания

avd.dmitriev@gmail.comSaint-Petersburg institute of emergency care n.a. I.I. DzhanelidzeГосударственное бюджетное учреждение «Научно-исследовательский институт скорой помощи им. И.И. Джанелидзе»Saint - Petersburg institute of emergency care n.a. I.I.DzhanelidzeГосударственное бюджетное учреждение Санкт-Петербургский научно-исследовательский институт скорой помощи имени И.И. Джанелидзе230420201127351802202018032020Copyright ©; 2020, Luft V.V., Dmitriev A.V.Copyright ©; 2020, Луфт В.М., Дмитриев А.В.2020Luft V.V., Dmitriev A.V.Луфт В.М., Дмитриев А.В.https://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/2658-4433/article/view/20778

It has been established that HIV-infection is associated with progressive deficiency of L-glutamine followed by immune dysfunction, reduced body mass and muscle strength, morphological disorders and functional disintegration of the intestine, as well as neurological disorders. According to current ideas, correction of L-glutamine deficiency is one of the important components of adjuvant therapy for HIV-infected patients within general nutritional support strategy. This measure helps to slow development of AIDS, reduce side effects of antiretroviral therapy and enhance effectiveness.

Установлено, что ВИЧ-инфекция связана с прогрессирующим дефицитом L-глутамина, за которым следуют иммунная дисфункция, снижение массы тела и мышечной силы, морфологические нарушения и функциональная дезинтеграция кишечника, а также неврологические нарушения. Согласно современным представлениям, коррекция дефицита L-глутамина является одним из важных компонентов адъювантной терапии для ВИЧ-инфицированных пациентов в рамках общей стратегии поддержки питания. Эта мера помогает замедлить развитие СПИДа, уменьшить побочные эффекты антиретровирусной терапии и повысить ее эффективность.

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