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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Clinical nutrition and metabolism</journal-id><journal-title-group><journal-title xml:lang="en">Clinical nutrition and metabolism</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническое питание и метаболизм</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2658-4433</issn><issn publication-format="electronic">2782-2974</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">677803</article-id><article-id pub-id-type="doi">10.17816/clinutr677803</article-id><article-id pub-id-type="edn">KSNHQG</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Nutritional support in acute pancreatitis: a review of clinical guidelines</article-title><trans-title-group xml:lang="ru"><trans-title>Нутритивная поддержка при остром панкреатите: обзор клинических рекомендаций</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4995-1048</contrib-id><contrib-id contrib-id-type="spin">8520-0376</contrib-id><name-alternatives><name xml:lang="en"><surname>Kotchergin</surname><given-names>Vladimir G.</given-names></name><name xml:lang="ru"><surname>Кочергин</surname><given-names>Владимир Гаврилович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>asqwerty1@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8121-4160</contrib-id><name-alternatives><name xml:lang="en"><surname>Pasechnik</surname><given-names>Igor N.</given-names></name><name xml:lang="ru"><surname>Пасечник</surname><given-names>Игорь Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><email>pasigor@yandex.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Moscow Clinical Scientific Center n.a. A.S. Loginov</institution></aff><aff><institution xml:lang="ru">Московский клинический научно-практический центр им. А.С. Логинова</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">The Russian National Research Medical University named after N.I. Pirogov</institution></aff><aff><institution xml:lang="ru">Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Central State Medical Academy</institution></aff><aff><institution xml:lang="ru">Центральная государственная медицинская академия</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-06-30" publication-format="electronic"><day>30</day><month>06</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-08-12" publication-format="electronic"><day>12</day><month>08</month><year>2025</year></pub-date><volume>5</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>179</fpage><lpage>186</lpage><history><date date-type="received" iso-8601-date="2025-03-31"><day>31</day><month>03</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-06-18"><day>18</day><month>06</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/2658-4433/article/view/677803">https://journals.eco-vector.com/2658-4433/article/view/677803</self-uri><abstract xml:lang="en"><p>In recent years, nutritional support in acute pancreatitis has undergone significant changes. For a long time, treatment was based on the concept of pancreatic rest, which implied fasting and total parenteral nutrition. However, recent studies have demonstrated a clear advantage of early oral or enteral feeding. Nevertheless, many issues related to the tactics and composition of nutritional support remain unresolved.</p> <p>This review presents current data on nutritional support as part of comprehensive therapy for acute pancreatitis. A scientific data search was conducted in the eLIBRARY.RU, PubMed, and ScienceDirect databases using the keywords: “acute pancreatitis,” “nutritional support,” “probiotics,” “glutamine,” “omega-3 fatty acids” and “guidelines”.</p> <p>The analysis showed that oral or enteral nutrition should be initiated as early as possible—within the first 24–48 hours after hospital admission. The review addresses methods of intragastric and postpyloric nutrient administration, indications for percutaneous gastro- or jejunostomy placement, and also presents current perspectives on the necessity of additional administration of pharmaconutrients and probiotics. In addition, an algorithm for prescribing nutritional support in acute pancreatitis is provided. Accumulated evidence confirms that early oral or enteral nutrition is an essential component of intensive care for patients with acute pancreatitis.</p></abstract><trans-abstract xml:lang="ru"><p>В последние годы нутритивная поддержка при остром панкреатите претерпела значительные изменения. Долгое время основой лечения была концепция «панкреатического покоя», подразумевавшая голодание и полное парентеральное питание. Однако недавние исследования доказали значительное преимущество раннего перорального или энтерального питания. Тем не менее многие вопросы тактики и состава нутритивной поддержки до сих пор не решены.</p> <p>В настоящем обзоре представлены актуальные данные о нутритивной поддержке в составе комплексной терапии острого панкреатита. Поиск литературы проведён в базах данных eLibrary, PubMed, ScienceDirect по ключевым словам: «острый панкреатит», «нутритивная поддержка», «пробиотики», «глутамин», «омега-3 жирные кислоты», «рекомендации».</p> <p>Анализ показал, что пероральное или энтеральное питание необходимо начинать как можно раньше — в первые 24–48 ч после госпитализации. В обзоре рассмотрены способы внутрижелудочного и внутрикишечного введения нутриентов, показания для наложения чрескожной гастро- или еюностомы, также представлен современный взгляд на необходимость дополнительного назначения фармаконутриентов и пробиотиков. Кроме того, подробно изложен алгоритм назначения нутритивной поддержки при остром панкреатите. Накопленные данные подтверждают, что раннее пероральное или энтеральное питание — обязательная составляющая интенсивной терапии пациентов с острым панкреатитом.</p></trans-abstract><kwd-group xml:lang="en"><kwd>acute pancreatitis</kwd><kwd>nutritional support</kwd><kwd>probiotics</kwd><kwd>glutamine</kwd><kwd>omega-3 fatty acids</kwd><kwd>guidelines</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>острый панкреатит</kwd><kwd>нутритивная поддержка</kwd><kwd>пробиотики</kwd><kwd>глутамин</kwd><kwd>омега-3 жирные кислоты</kwd><kwd>рекомендации</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Проведение работы и публикация статьи осуществлены на личные средства авторского коллектива</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Li Cl, Jiang M, Pan Cq. et al. The global, regional, and national burden of acute pancreatitis in 204 countries and territories, 1990–2019. BMC Gastroenterol. 2021;21(1):332. doi: 10.1186/s12876-021-01906-2 EDN: PMDZEO</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Gapp J, Hall AG, Walters RW, et al. Trends and outcomes of hospitalizations related to acute pancreatitis: epidemiology from 2001 to 2014 in the United States. Pancreas. 2019;48(4):548-554. doi: 10.1097/MPA.0000000000001275</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Arvanitakis M, Dumonceau JM, Albert J, et al. Endoscopic management of acute necrotizing pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) evidence-based multidisciplinary guidelines. Endoscopy. 2018;50(5):524-546. doi: 10.1055/a-0588-5365 EDN: WWDCYJ</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Werge M, Novovic S, Schmidt PN, Gluud LL. Infection increases mortality in necrotizing pancreatitis: a systematic review and meta-analysis. Pancreatology. 2016;16(5):698-707. doi: 10.1016/j.pan.2016.07.004</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>De Pretis N, Amodio A, Frulloni L. Hypertriglyceridemic pancreatitis: epidemiology, pathophysiology and clinical management. United Eur. Gastroenterol. J. 2018;6(5):649-655. doi: 10.1177/2050640618755002</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Iannuzzi JP, King JA, Leong JH, et al. Global incidence of acute pancreatitis is increasing over time: a systematic review and meta-analysis. Gastroenterology. 2022;162(1):122-134. doi: 10.1053/j.gastro.2021.09.043 EDN: VVFMJH</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Boxhoorn L, Voermans RP, Bouwense SA, et al. Acute pancreatitis. Lancet. 2020;396(10252):726-734. doi: 10.1016/S0140-6736(20)31310-6 EDN: PUPZPQ</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Zatevakhin II, Revishvili ASh, Bagnenko SF. Clinical recommendations of the Ministry of Health of the Russian Federation on acute pancreatitis. 2024. (In Russ.) Available from: https://cr.minzdrav.gov.ru/preview-cr/903_1</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Kahaleh M. Management of pancreatitis and pancreatic: fluid collections. Rev. Gastroenterol. Peru. 2018;38(2):169-182.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Szatmary P, Grammatikopoulos T, Cai W, et al. Acute pancreatitis: diagnosis and treatment. Drugs. 2022;82(12):1251-1276. doi: 10.1007/s40265-022-01766-4 EDN: VOJQXM</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Sellers ZM, Abu-El-Haija M, Husain SZ, Morinville V. New management guidelines for both children and adults with acute pancreatitis. Gastroenterology. 2018;155(1):234-235. doi: 10.1053/j.gastro.2018.03.068 EDN: YJQOFF</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>De-Madaria E, Buxbaum JL, Maisonneuve P, et al. Aggressive or moderate fluid resuscitation in acute pancreatitis. N. Engl. J. Med. 2022;387(11):989-1000. doi: 10.1056/NEJMoa2202884 EDN: KOFYMM</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Petrov MS, Yadav D. Global epidemiology and holistic prevention of pancreatitis. Nat. Rev. Gastroenterol. Hepatol. 2019;16(3):175-184. doi: 10.1038/s41575-018-0087-5</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Roberts KM, Nahikian-Nelms M, Ukleja A, Lara LF. Nutritional Aspects of Acute Pancreatitis. Gastroenterol. Clin. North Am. 2018;47(1):77-94. doi: 10.1016/j.gtc.2017.10.002</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Kochergin VG, Sviridov SV, Subbotin VV, Vetsheva MS. Trace elements and metalloenzymes in patients with acute pancreatitis. Clinical nutrition and metabolism. 2021;2(3):141–156. doi: 10.17816/clinutr99881 EDN: KFKVIR</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Arvanitakis M, Ockenga J, Bezmarevic M, et al. ESPEN guideline on clinical nutrition in acute and chronic pancreatitis. Clin. Nutr. 2020;39(3):612-631. doi: 10.1016/j.clnu.2020.01.004 EDN: XBDYSW</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Sitzmann JV, Steinborn PA, Zinner MJ, Cameron JL. Total parenteral nutrition and alternate energy substrates in treatment of severe acute pancreatitis. Surg. Gynecol. Obstet. 1989;168:311-317.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Li H, Qian Z, Liu Z, et al. Risk factors and outcome of acute renal failure in patients with severe acute pancreatitis. J. Crit. Care. 2010;25(2):225-229. doi: 10.1016/j.jcrc.2009.07.009</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Tenner S, Baillie J, DeWitt J, Vege SS. American College of Gastroenterology guideline: management of acute pancreatitis. Am. J. Gastroenterol. 2013;108(9):1400-1416. doi: 10.1038/ajg.2013.218 EDN: RKXRXJ</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Dickerson RN, Vehe KL, Mullen JL, Feurer ID. Resting energy expenditure in patients with pancreatitis. Crit. Care Med. 1991;19(4):484-490. doi: 10.1097/00003246-199104000-00005</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Krylov KYu, Sergeev IA, Yakovleva AV, et al. The role of indirect calorimetry in the treatment and rehabilitation of patients in long-term unconsciousness after brain damage. Clinical nutrition and metabolism. 2020;1(1):10–16. doi: 10.36425/clinnutrit21235 EDN: ZDUGHN</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>O’Keefe SJ, Lee RB, Anderson FP, et al. Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans. Am. J. Physiol. Gastrointest. Liver Physiol. 2003;284(1),27-36. doi: 10.1152/ajpgi.00155.2002</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>O’Keefe SJ, McClave SA. Feeding the injured pancreas. Gastroenterology. 2005;129(3):1129-1130. doi: 10.1053/j.gastro.2005.06.077</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Pearce CB, Sadek SA, Walters AM, et al. A double-blind, randomised, controlled trial to study the effects of an enteral feed supplemented with glutamine, arginine, and omega-3 fatty acid in predicted acute severe pancreatitis. JOP. 2006;7(4):361-371.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Lasztity N, Hamvas J, Biro L, et al. Effect of enterally administered n-3 polyunsaturated fatty acids in acute pancreatitis-a prospective randomized clinical trial. Clin. Nutr. 2005;24(1):198-205. doi: 10.1016/j.clnu.2004.12.008 EDN: TQOKPP</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Oláh A, Belágyi T, Issekutz A, et al. Randomized clinical trial of specific lactobacillus and fibre supplement to early enteral nutrition in patients with acute pancreatitis. Br. J. Surg. 2002;89:1103-1107. doi: 10.1046/j.1365-2168.2002.02189.x EDN: BABUSJ</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Oláh A, Belágyi T, Pótó L, et al. Synbiotic control of inflammation and infection in severe acute pancreatitis: a prospective, randomized, double blind study. Hepatogastroenterology. 2007;54(74):590-594.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Besselink MG, van Santvoort JC, Buskens E, et al. Probiotic prophylaxis in predicted severe acute pancreatitis: a randomised, double-blind, placebo-controlled trial. Lancet. 2008;371:651-659. doi: 10.1016/S0140-6736(08)60207-X</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Gou S, Yang Z, Liu T, et al. Use of probiotics in the treatment of severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials. Crit. Care. 2014;18(2):R57. doi: 10.1186/cc13809 EDN: SRVESW</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Klein E, Shnebaum S, Ben-Ari G, Dreiling DA. Effects of total parenteral nutrition on exocrine pancreatic secretion. Am. J. Gastroenterol. 1983;78:31-33.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Smit M, Buddingh KT, Bosma B, et al. Abdominal compartment syndrome and intra-abdominal ischemia in patients with severe acute pancreatitis. World J. Surg. 2016;40(6):1454-61. doi: 10.1007/s00268-015-3388-7 EDN: WLFJHA</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Jeurnink SM, Nijs MM, Prins HA, et al. Antioxidants as a treatment for acute pancreatitis: a meta-analysis. Pancreatology. 2015;15(3):203-8. doi: 10.1016/j.pan.2015.03.009</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Jafari T, Feizi A, Askari G, Fallah AA. Parenteral immunonutrition in patients with acute pancreatitis: a systematic review and meta-analysis. Clin. Nutr. 2015;34(1):35-43. doi: 10.1016/j.clnu.2014.05.008 EDN: USKYYN</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Ockenga J, Borchert K, Rifai K, et al. Effect of glutamine-enriched total parenteral nutrition in patients with acute pancreatitis. Clin. Nutr. 2002;21(5):409-16. doi: 10.1054/clnu.2002.0569</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Xian-li H, Qing-jiu M, Jian-Guo L, et al. Effect of total parenteral nutrition (TPN) with and without glutamine dipeptide supplementation on outcome on severe acute pancreatitis (SAP). Clin. Nutrition Supplements. 2004;1(1):43-47. doi: 10.1016/j.clnu.2004.07.011 EDN: CJVOTD</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Sahin H, Mercanligil SM, Inanc N, Ok E. Effects of glutamine-enriched total parenteral nutrition on acute pancreatitis. Eur. J. Clin. Nutr. 2007;61(12):1429-1434. doi: 10.1038/sj.ejcn.1602664</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Fuentes-Orozco C, Cervantes-Guevara G, Muciño-Hernández I, et al. L-alanyl-L-glutamine-supplemented parenteral nutrition decreases infectious morbidity rate in patients with severe acute pancreatitis. J. Parenter. Enteral. Nutr. 2008;32(4):403-11. doi: 10.1177/0148607108319797</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Xue P, Deng LH, Xia Q, et al. Impact of alanyl-glutamine dipeptide on severe acute pancreatitis in early stage. World J. Gastroenterol. 2008;14(3):474-8. doi: 10.3748/wjg.14.474</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Asrani V, Chang WK, Dong Z, et al. Glutamine supplementation in acute pancreatitis: a meta-analysis of randomized controlled trials. Pancreatology. 2013;13(5):468-74. doi: 10.1016/j.pan.2013.07.282 EDN: SPYALV</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Yong L, Lu QP, Liu SH, Fan H. Efficacy of glutamine-enriched nutrition support for patients with severe acute pancreatitis: A meta-analysis. JPEN J. Parenteral. Nutr. 2016;40(1):83-94. doi: 10.1177/0148607115570391 EDN: WRFSYN</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Wang X, Li W, Li N, Li J. Omega-3 fatty acids-supplemented parenteral nutrition decreases hyperinflammatory response and attenuates systemic disease sequelae in severe acute pancreatitis: a randomized and controlled study. J. Parenter. Enteral. Nutr. 2008;32(3):236-41. doi: 10.1177/0148607108316189</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Xiong J, Zhu S, Zhou Y, et al. Regulation of omega-3 fish oil emulsion on the SIRS during the initial stage of severe acute pancreatitis. J. Huazhong Univ. Sci. Technolog. Med. Sci. 2009;29(1):35-8. doi: 10.1007/s11596-009-0107-3 EDN: MXXYYZ</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Petrikov SS, Khubutia MSh, Popova TS, editors. Parenteral and enteral nutrition: national guidelines. 2nd ed. Moscow: GEOTAR-Media, 2023. (In Russ.) ISBN: 978-5-9704-7277-4 doi: 10.33029/9704-7277-4-PAR-2023-1-1168 EDN: FXMQGG</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Zhang J, Zhu S, Tan D, et al. A meta-analysis of early oral refeeding and quickly increased diet for patients with mild acute pancreatitis. Saudi J. Gastroenterol. 2019;25(1):14-19. doi: 10.4103/sjg.SJG_240_18</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Li J, Xue G-J, Liu Y-L, et al. Early oral refeeding wisdom in patients with mild acute pancreatitis. Pancreas. 2013;42(1):88-91. doi: 10.1097/MPA.0b013e3182575fb5</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Lariño-Noia J, Lindkvist B, Iglesias-García J, et al. Early and/or immediately full caloric diet versus standard refeeding in mild acute pancreatitis: a randomized open-label trial. Pancreatology. 2014;14(3):167-173. doi: 10.1016/j.pan.2014.02.008</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Witteman BJ, Gooszen HG, Dijkgraaf MG, et al. Endoscopic or surgical step-up approach for infected necrotising pancreatitis: a multicentre randomised trial. Lancet. 2018;391(10115):51-58. doi: 10.1016/S0140-6736(17)32404-2 EDN: IRBQGA</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Arvanitakis M, Ockenga J, Bezmarevic M, et al. ESPEN practical guideline on clinical nutrition in acute and chronic pancreatitis. Clin. Nutr. 2024;43(2):395-412. doi: 10.1016/j.clnu.2023.12.019 EDN: JDYTUU</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Wu LM, Sankaran SJ, Plank LD, et al. Meta-analysis of gut barrier dysfunction in patients with acute pancreatitis. Br. J. Surg. 2014;101(13):1644-1656. doi: 10.1002/bjs.9665 EDN: TFQBIT</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Petrov MS, van Santvoort HC, Besselink MG, et al. Enteral nutrition and the risk of mortality and infectious complications in patients with severe acute pancreatitis: a meta-analysis of randomized trials. Arch. Surg. 2008;143(11):1111-1117. doi: 10.1001/archsurg.143.11.1111 EDN: MMOVCD</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Li W, Liu J, Zhao S, Li J. Safety and efficacy of total parenteral nutrition versus total enteral nutrition for patients with severe acute pancreatitis: a metaanalysis. J. Int. Med. Res. 2018;46(9):3948-3958. doi: 10.1177/0300060518782070 EDN: YKCPYD</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Nally DM, Kelly EG, Clarke M, Ridgway P. Nasogastric nutrition is efficacious in severe acute pancreatitis: a systematic review and meta-analysis. Br. J. Nutr. 2014;112(11):1769-1778. doi: 10.1017/S0007114514002566 EDN: UTQDBP</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Chang YS, Fu HQ, Xiao YM, Liu JC. Nasogastric or nasojejunal feeding in predicted severe acute pancreatitis: a meta-analysis. Crit. Care. 2013;17(3):R118. doi: 10.1186/cc12790 EDN: RLAVXR</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Wang M, Shi H, Chen Q, et al. Comparative safety assessment of nasogastric versus nasojejunal feeding initiated within 48 hours post-admission versus unrestricted timing in moderate or severe acute pancreatitis: a systematic review and meta-analysis. BMC Gastroenterol. 2024;24(1):207. doi: 10.1186/s12876-024-03290-z EDN: IUPUCU</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Blaser AR, Starkopf J, Alhazzani W, et.al. Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines. Intensive Care Med. 2017;43(3):380-398. doi: 10.1007/s00134-016-4665-0 EDN: ZSQULF</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Blaser AR, Malbrain MLNG, Regli A. Abdominal pressure and gastrointestinal function: an inseparable couple? Anaesthesiol. Intensive Ther. 2017;49(2):146-158. doi: 10.5603/AIT.a2017.0026 EDN: YILIZH</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Gupta R, Patel K, Calder PC, et al. A randomised clinical trial to assess the effect of total enteral and total parenteral nutritional support on metabolic, inflammatory and oxidative markers in patients with predicted severe acute pancreatitis (APACHE II &gt; or =6). Pancreatology. 2003;3(5):406-13. doi: 10.1159/000073657</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Pupelis G, Selga G, Austrums E, Kaminski A. Jejunal feeding, even when instituted late, improves outcomes in patients with severe pancreatitis and peritonitis. Nutrition. 2001;17(2):91-4. doi: 10.1016/s0899-9007(00)00508-6</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Meier R, Ockenga J, Pertkiewicz M, et al. ESPEN guidelines on enteral nutrition: Pancreas. Clin. Nutr. 2006;25(2):275-84. doi: 10.1016/j.clnu.2006.01.019</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Poropat G, Giljaca V, Hauser G, Štimac D. Enteral nutrition formulations for acute pancreatitis. Cochrane Database Syst. Rev. 2015;2015(3):CD010605. doi: 10.1002/14651858.CD010605.pub2 EDN: TBHDFY</mixed-citation></ref></ref-list></back></article>
