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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Clinical nutrition and metabolism</journal-id><journal-title-group><journal-title xml:lang="en">Clinical nutrition and metabolism</journal-title><trans-title-group xml:lang="ru"><trans-title>Клиническое питание и метаболизм</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2658-4433</issn><issn publication-format="electronic">2782-2974</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">686549</article-id><article-id pub-id-type="doi">10.17816/clinutr686549</article-id><article-id pub-id-type="edn">CZRRGS</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Effectiveness of multimodal medical rehabilitation program in a patient with esophageal cancer, severe metabolic disturbances, and functional deficiency: A case report</article-title><trans-title-group xml:lang="ru"><trans-title>Эффективность программы мультимодальной медицинской реабилитации больного раком пищевода с тяжёлыми метаболическими нарушениями и функциональным дефицитом. Клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0197-7721</contrib-id><contrib-id contrib-id-type="spin">6876-7701</contrib-id><name-alternatives><name xml:lang="en"><surname>Obukhova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Обухова</surname><given-names>Ольга Аркадьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>obukhova0404@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8463-2600</contrib-id><contrib-id contrib-id-type="spin">3692-5202</contrib-id><name-alternatives><name xml:lang="en"><surname>Kurmukov</surname><given-names>Ildar A.</given-names></name><name xml:lang="ru"><surname>Курмуков</surname><given-names>Илдар Анварович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>kurmukovia@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9562-9113</contrib-id><contrib-id contrib-id-type="spin">4410-8937</contrib-id><name-alternatives><name xml:lang="en"><surname>Yunaev</surname><given-names>Grigory S.</given-names></name><name xml:lang="ru"><surname>Юнаев</surname><given-names>Григорий Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>garik_dr@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2902-077X</contrib-id><contrib-id contrib-id-type="spin">9541-9030</contrib-id><name-alternatives><name xml:lang="en"><surname>Shagina</surname><given-names>Natalya Yu.</given-names></name><name xml:lang="ru"><surname>Шагина</surname><given-names>Наталья Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><email>gonch-ponch@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Russian Cancer Research Center NN Blokhin</institution></aff><aff><institution xml:lang="ru">Национальный медицинский исследовательский центр онкологии имени Н.Н. Блохина</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Sechenov University</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-07-18" publication-format="electronic"><day>18</day><month>07</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-08-12" publication-format="electronic"><day>12</day><month>08</month><year>2025</year></pub-date><volume>5</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>187</fpage><lpage>194</lpage><history><date date-type="received" iso-8601-date="2025-07-02"><day>02</day><month>07</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-07-08"><day>08</day><month>07</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/2658-4433/article/view/686549">https://journals.eco-vector.com/2658-4433/article/view/686549</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND</bold>: Following neoadjuvant chemotherapy (NACT), patients with esophageal cancer may develop severe functional impairments that render radical surgical intervention impossible. We present a clinical case of severe functional deficiency that developed in a patient with esophageal cancer during NACT, necessitating comprehensive medical rehabilitation prior to radical surgical intervention.</p> <p><bold>Case</bold><bold> </bold><bold>description</bold><bold>:</bold> A 75-year-old male was diagnosed with adenocarcinoma of the distal esophagus, stage cT3N0M0 (stage II). He received four cycles of antitumor therapy using the FLOT regimen (fluorouracil, calcium folinate, oxaliplatin, docetaxel), with a positive response. Radical surgical treatment was indicated; however, severe functional decline combined with metabolic disturbances precluded the procedure. A multimodal medical rehabilitation program, including therapeutic exercise, limb massage, nutritional support, and correction of metabolic and fluid-electrolyte imbalances, enabled clinical stabilization of patient within a short period.</p> <p><bold>CONCLUSION:</bold> Given the multifaceted nature of functional impairments in patients with esophageal cancer, medical rehabilitation should be based on multimodal programs incorporating symptomatic drug therapy. This approach appears to be optimal in this patient cohort.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> После проведения неоадъювантной химиотерапии (НАХТ) у больных раком пищевода могут развиться тяжёлые нарушения функционального статуса, что делает проведение радикального хирургического вмешательства неосуществимым. Мы представляем клинический случай тяжёлого функционального дефицита, развившегося у больного раком пищевода во время проведения НАХТ, который потребовал проведения комплексной медицинской реабилитации перед выполнением радикального хирургического вмешательства.</p> <p><bold>Описание случая. </bold>Мужчине 75 лет, диагноз: аденокарцинома дистального отдела пищевода сТЗN0М0 II ст., получившего 4 курса противоопухолевого лечения в режиме FLOT (фторурацил, кальция фолинат, оксалиплатин, доцетаксел), с положительной динамикой, было показано проведение радикального хирургического вмешательства, однако тяжёлые нарушения функционального статуса в совокупности с метаболическими изменениями препятствовали этому. Мультимодальная программа медицинской реабилитации, которая включала лечебную физкультуру, массаж конечностей, нутритивную поддержку, коррекцию метаболических и водно-электролитных нарушений, позволила стабилизировать состояние больного в короткий срок.</p> <p><bold>Заключение.</bold> Принимая во внимание многогранную природу функциональных нарушений больных раком пищевода, при проведении медицинской реабилитации следует использовать мультимодальные программы с применением симптоматической лекарственной терапии. Такой подход является наиболее оптимальным в данной когорте пациентов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>chemotherapy</kwd><kwd>esophageal cancer</kwd><kwd>indirect calorimetry</kwd><kwd>nutritional support</kwd><kwd>rehabilitation</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>химиотерапия</kwd><kwd>рак пищевода</kwd><kwd>непрямая калориметрия</kwd><kwd>нутритивная поддержка</kwd><kwd>реабилитация</kwd><kwd>клинический случай</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Проведение работы и публикация статьи осуществлены на личные средства авторского коллектива</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Petrikov SS, Khubutia MSh, Popova TS, editors. Parenteral and enteral nutrition: national guidelines. 2nd ed. Moscow: GEOTAR-Media; 2023. (In Russ) doi: 10.33029/9704-7277-4-PAR-2023-1-1168 EDN: FXMQGG</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Cederholm T, Jensen GL, Correia MITD, et al. GLIM criteria for the diagnosis of malnutrition — A consensus report from the global clinical nutrition community. Clin Nutr. 2019;38(1):1-9. doi: 10.1016/j.clnu.2018.08.002</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Aaronson NK, Ahmedzai S, Bergman B, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst. 1993;85(5):365-376. doi: 10.1093/jnci/85.5.365 EDN: ISNQSB</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Kurmukov IA, Obukhova OA. Venous access for parenteral nutrition: changes in Europe and North America over the past 12 years. Clinical nutrition and metabolism. 2021;2(1):5-12. (In Russ.). doi: 10.17816/clinutr79378 EDN: DVJNBG</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Ivanova AS, Obukhova OA, Kurmukov IA, Volf LYa. Review of ESPEN-2021 Practice Guidelines for Cancer Patients: Part 1. Clinical nutrition and metabolism. 2022;3(3):140-152. (In Russ.) doi: 10.17816/clinutr111900 EDN: YLUOMT</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Persiyanova-Dubrova AL, Matveeva IF, Bubnova MG. Borg scale in cardiac rehabilitation: methodology and prospects for use. Russian Journal of Preventive Medicine. 2022;25(9):90-96. (In Russ.) doi: 10.17116/profmed20222509190</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Grushina TI. Rehabilitation in oncology: physiotherapy. Moscow: GEOTAR-Media; 2006. (In Russ.) EDN: QLMZBJ Available from: https://msrabota.ru/biblioteka/show/289</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ivanova AS, Obukhova OA, Kurmukov IA. Pre-rehabilitation as a possible component of ERAS protocol in modern operative gynecologic oncology. Oncogynecology. 2022;4(44):60-70. (In Russ.) doi: 10.52313/22278710_2022_4_60 EDN: KMPRWN</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Dettling DS, van der Schaaf M, Blom RLGM, et al. Feasibility and effectiveness of pre-operative inspiratory muscle training in patients undergoing oesophagectomy: a pilot study. Physiother. Res. Int. 2013;18(1):16-26. doi: 10.1002/pri.1524</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Minnella EM, Awasthi R, Loiselle SE, et al. Effect of Exercise and Nutrition Prehabilitation on Functional Capacity in Esophagogastric Cancer Surgery: A Randomized Clinical Trial. JAMA Surg. 2018;153(12):1081-1089 doi: 10.1001/jamasurg.2018.1645</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Valkenet K, Trappenburg JCA, Ruurda JP, et al. Multicentre randomized clinical trial of inspiratory muscle training versus usual care before surgery for oesophageal cancer. Br. J. Surg. 2018;105(5):502-511. doi: 10.1002/bjs.10803</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Papaconstantinou D, Vretakakou K, Paspala A, Misiakos EP, Charalampopoulos A, Nastos C, et al. The impact of preoperative sarcopenia on postoperative complications following esophagectomy for esophageal neoplasia: a systematic review and meta-analysis. Dis Esophagus. 2020;33(7):doaa002. doi: 10.1093/dote/doaa002 EDN: ZMNTNC</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Park A, Orlandini MF, Szor DJ, et al. The impact of sarcopenia on esophagectomy for cancer: a systematic review and meta-analysis. BMC Surg. 2023;23(1):240. doi: 10.1186/s12893-023-02149-6 EDN: MCUYTP</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Wakita A, Motoyama S, Sato Y, et al. Preoperative neoadjuvant chemoradiotherapy provides borderline resectable thoracic esophageal cancer with equivalent treatment results as clinically T3 thoracic esophageal cancer. Ann Gastroenterol Surg. 2023;7:904-912. doi: 10.1002/ags3.12706 EDN: AXLGWV</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Guinan EM, Doyle SL, Bennett AE, et al. Sarcopenia during neoadjuvant therapy for oesophageal cancer: characterising the impact on muscle strength and physical performance. Support Care Cancer. 2018;26(5):1569-1576. doi: 10.1007/s00520-017-3993-0 EDN: QAGXBE</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Halliday LJ, Doganay E, Wynter-Blyth VA, et al. The Impact of Prehabilitation on Post-operative Outcomes in Oesophageal Cancer Surgery: a Propensity Score Matched Comparison. J Gastrointest Surg. 2021;25(11):2733-2741. doi: 10.1007/s11605-020-04881-3 EDN: JNOVKK</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Mitzman B, Schipper PH, Edwards MA, et al. Complications After Esophagectomy Are Associated With Extremes of Body Mass Index. Ann Thorac Surg. 2018;106(4):973-980. doi: 10.1016/j.athoracsur.2018.05.056</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Van Kooten RT, Voeten DM, Steyerberg EW, et al. Patient-Related Prognostic Factors for Anastomotic Leakage, Major Complications, and Short-Term Mortality Following Esophagectomy for Cancer: A Systematic Review and Meta-Analyses. Ann Surg Oncol. 2022;29(2):1358-1373. doi: 10.1245/s10434-021-10734-3 EDN: UQSDDA</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Polenova NV, Varaeva YuR, Pogonchenkova IV, et al. Physical activity in sarcopenia: rehabilitation approaches in prevention and treatment of age-related muscle disorders. Problems of Balneology, Physiotherapy and Exercise Therapy. 2023;100(2):52-60. (In Russ.) doi: 10.17116/kurort202310002152 EDN: TSCKPN</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Lavriv DS, Neves PM, Ravasco P. Should omega-3 fatty acids be used for adjuvant treatment of cancer cachexia? Clin Nutr ESPEN. 2018;25:18-25. doi: 10.1016/j.clnesp.2018.02.006</mixed-citation></ref></ref-list></back></article>
