Vol 5, No 4 (2025)

The search for effective and safe treatment methods in dentistry and surgery remains highly relevant. Conventional routes of drug administration often fail to achieve the required concentration of medications at the site of inflammation, leading to chronicity of pathological processes and an increased risk of systemic adverse effects. In this context, lymphotropic therapy represents a promising approach, involving targeted drug delivery directly to the pathological focus via the lymphatic system. The method is based on subcutaneous or interstitial administration of medications, which, entering the lymphatic capillaries, create high concentrations specifically in the affected area and regional lymph nodes. This article systematizes data from contemporary domestic and international studies confirming the pathogenetic validity and high efficacy of this method in the комплекс treatment of inflammatory diseases of the periodontium, salivary glands, odontogenic infections, purulent-inflammatory processes of the maxillofacial region, as well as in the prevention of postoperative complications such as lymphedema. The main proven advantages of the method include the formation of a depot of high drug concentration directly at the site of lesion, a significant reduction in the risk of systemic adverse reactions, a comprehensive therapeutic effect including restoration of the drainage function of the lymphatic system, and a reduction in treatment duration. The prospects for further development of the method are associated with optimization of drug formulations and integration into treatment protocols for a wide range of dental conditions.

Falsification of medicines is a serious threat to national drug supply systems. In the context of the globalization of the pharmaceutical market, there is a need to introduce reliable mechanisms for the identification of medicines. The purpose of this study is to analyze the role of modern identification systems in ensuring the authenticity of medicines at the national and international levels. The work uses regulatory legal acts of the Russian Federation, official reports of Roszdravnadzor, as well as scientific publications from the eLibrary databases.RU and DisserCat for 2014-2025 It is shownthat the Honest MARK identification system provides a high degree of traceability at the national level, while IDMP creates the basis for global standardization of drug descriptions. The expediency of step-by-step integration of IDMP elements into the Russian pharmacovigilance system is substantiated.

Due to the low level of physical activity in the population, there is an annual increase in cardiovascular, oncological, neuropsychiatric, and allergic diseases. Many people do not adhere to the basic norms of a healthy lifestyle. Due to a sedentary lifestyle and prolonged work both at work and at home, the majority of the population experiences a deficit of physical activity in their daily routine, leading to hypokinesia, which can cause a number of serious changes in the human body. Additionally, the health of modern individuals is affected by the fast pace of life, environmental pollution, improper nutrition, and the emergence of harmful factors such as radiation and ionizing radiation.

To maintain the functional level of the body, muscle condition, and psychophysical state, physical exercise plays a significant role. Moderate physical activity is accompanied by muscle hypertrophy, as well as strengthening of the musculoskeletal system and increased joint mobility. Taking into account the individual's level of fitness, appropriate physical loads are applied, and in case of deviations, therapeutic exercise is used. A mismatch between the load and the individual's preparedness can lead to the development of pathologies; therefore, physical loads must be properly selected and dosed, avoiding overexertion during training.

To achieve the best effect, it is necessary to adhere to the following principles of physical education: a systematic approach, regularity, duration, consistency, and gradual increase in load. During physical education classes, it is recommended to monitor heart rate. During physical exertion, cellular metabolism processes in the body intensify, increasing the need for additional oxygen and nutrients. Exercises contribute to the functional transformation of all parts of the human skeletal system, thereby improving metabolic processes in tissues.

Properly selected load, regular performance, and high physical activity are effective means of improving human health and increasing the body's resistance to damaging environmental factors.

The article is devoted to the study of the influence of individual food categories on the risk and incidence of type 2 diabetes mellitus in a 7-year prospective observational study "ESSE-RF2" conducted in the Omsk region. The analysis showed that daily consumption of meat products, pasta, and cheese significantly increases the likelihood of developing type 2 diabetes, while regular intake of vegetables, cottage cheese, and whole-grain cereals is associated with a reduced risk. The obtained data confirm the importance of a balanced diet for the prevention of diabetes mellitus, including the consumption of at least 400 g of vegetables per day. The study emphasizes the need for further research on dietary factors to develop recommendations for healthy nutrition for the population.

In the context of a rapidly evolving pharmaceutical market and the introduction of innovative medicinal products, there is an increasing need for training specialists with comprehensive knowledge of the life cycle of medicinal products and the mechanisms of their circulation. Pharmacology is the core discipline that provides students with fundamental knowledge about drugs; however, it is not possible to cover all aspects related to the circulation of medicinal products within a single discipline. In order to improve the quality of student training in pharmacology, the course "Fundamentals of Pharmaceutical Science" was introduced into the educational program for General Medicine at Omsk State Medical University. The course is aimed at developing students' basic understanding of the nomenclature and properties of medicinal substances, principles of their classification, as well as drug development and quality control.

Objective. To evaluate the effectiveness of the course "Fundamentals of Pharmaceutical Science" as a propaedeutic module preceding the study of pharmacology.

Materials and Methods. An anonymous survey was conducted among third-year medical students (n = 40) who had previously completed the course. The questionnaire included sections aimed at assessing the practical usefulness of the course in studying pharmacology. The effectiveness indicator was the integral usefulness score.

Results. According to the study results, the integral usefulness score of the course was 6.5 ± 2.7; 50% of students rated it as "highly useful", and 25% as "moderately useful". Additionally, 70% of respondents reported actively applying the acquired knowledge while studying pharmacology.

Discussion. The obtained data indicate the practical significance of introducing the course "Fundamentals of Pharmaceutical Science" as a mandatory component of the educational program. Its implementation contributes to the standardization of students' baseline knowledge, the development of устойчивых interdisciplinary links, and increased efficiency in further pharmacology studies.

Conclusion. Thus, the course "Fundamentals of Pharmaceutical Science" can be reasonably considered an effective propaedeutic module with proven practical significance for mastering pharmacology, ensuring standardization of baseline training and improving the effectiveness of clinically oriented education.