Medical academic journalMedical academic journalМедицинский академический журнал1608-41012687-1378Eco-Vector1006410.17816/MAJ1025-16ArticlesСтатьиReview ArticleThe role of naturally occurring regulatory CD4 +CD25 + T-cell subpopulation in the normal state and in various diseasesРоль субпопуляции естественных регуляторных CD4 +CD25 + Т-клеток в норме и при патологииAkinflevaO VАкинфиеваОльга Викторовнаolgaakinf@yandex.ruBubnovaL NБубноваЛ НФГУ «Российский научно-исследовательский институт гематологии и трансфузиологии»15062010102VOL 10, NO2 (2010)ТОМ 10, №2 (2010)51603092018Copyright ©; 2010, Akinfleva O.V., Bubnova L.N.Copyright ©; 2010, Акинфиева О.В., Бубнова Л.Н.2010Akinfleva O.V., Bubnova L.N.Акинфиева О.В., Бубнова Л.Н.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/MAJ/article/view/10064

Naturally occurring regulatory CD4 +CD25 + T cells (Treg cells) play a crucial role in the maintenance of normal immunohomeostasis.T reg cells suppress the activity of effector T cells thus taking part in the prevention of the development of autoimmune processes, whereas the inhibition of Treg cells activity can lead to the manifestation of severe or even fatal autoimmune and lymphoproliferative diseases. It has been shown that CD4 +CD25 +Treg cells play an important role in the suppression of graft-versus-host reaction, in the prevention of the development of allergic disorders and in the suppression of immune response to opportunistic pathogens. In patients with malignant neoplasms T reg cells inhibit the productive immune response against tumor.

Естественные регуляторные CD4 +CD25 +Т-лимфоциты (Т ед-клетки) играют ключевую роль в поддержании нормального иммунного гомеостаза. Treg-клетки ингибируют активность эффекторныхТ-лимфоцитов, участвуя в предотвращении развития аутоиммунных процессов, тогда как подавление их активности может приводить к возникновению тяжелых или фатальных аутоиммунных и лимфопролиферативных заболеваний. Показана роль CD4 +CD25 +T reg-KaeTOK в супрессии реакции трансплантат против хозяина, предотвращении развития аллергических реакций, а также подавлении иммунного ответа при поражении организма патогенами. В организме пациентов со злокачественными новообразованиями Т гед-клетки подавляют противоопухолевый иммунный ответ.

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