Medical academic journalMedical academic journalМедицинский академический журнал1608-41012687-1378Eco-Vector1168010.17816/MAJ1847-16ArticlesСтатьиResearch ArticleHIV infection, secondary conditions and comorbidities. Part 1: Epidemiology and the basis of the problemВИЧ-инфекция, вторичные и коморбидные заболевания.Часть 1: Эпидемиология и основа проблемыBelyakovNikolay A.БеляковНиколай Алексеевич
Russian Federation

MD, PhD, Professor, Academician of the Russian Academy of Sciences, Head of the Department of Socially Significant Infections; Head of the North-Western District AIDS Prevention and Control Center; Head of the Department of Socially Significant Infections

д-р мед. наук, профессор, академик РАН, зав. кафедрой социально-значимых инфекций; руководитель Северо-Западного Окружного центра по профилактике и борьбе со СПИД ;главный научный сотрудник

ras-doc@mail.ruRassokhinVadim V.РассохинВадим Владимирович
Russian Federation

MD, PhD, Professor of the Department of Socially Significant Infections; Leading research associate; Head of the Laboratory of Chronic Viral Infections, Department of Ecological Physiology

д-р мед. наук, профессор кафедры социально-значимых инфекций; ведущий научный сотрудник; заведующий лабораторией хронических вирусных инфекций отдела экологической физиологии

ras-doc@mail.ruStepanovaElena V.СтепановаЕлена Владимировна
Russian Federation

Professor, Department of Socially Significant Infections; MD, PhD, Deputy Chief Medical Officer

профессор кафедры социально-значимых инфекций; д-р мед. наук, зам. главного врача по медицинской части

boeva@gmail.comLeonovaOlga N.ЛеоноваО Н
Russian Federation

MD, PhD, Associate Professor of the Department of Socially Significant Infections; Head of the Saint Petersburg Center for Prevention and Control of AIDS and Infectious Diseases

канд. мед. наук, доцент кафедры социально-значимых инфекций; зав. отделением СПб ГБУЗ «Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями»

boeva@gmail.comBoevaEkaterina V.БоеваЕкатерина Валериевна
Russian Federation

Assistant of the Department of socially significant infections; Head of the Department of Chronic Viral Infection

ассистент кафедры социально-значимых инфекций; зав. отделением хронической вирусной инфекции

boeva@gmail.comPavlov First Saint Petersburg State Medical UniversityФБГОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава РоссииSaint Petersburg Pasteur Research Institute of Epidemiology and MicrobiologyФБУН «Санкт-Петербургский НИИ эпидемиологии и микробиологии имени Пастера»Institute of Experimental MedicineФГБНУ «Институт экспериментальной медицины»Saint Petersburg Centre for Prevention and Control of AIDS and Infectious DiseasesСПб ГБУЗ «Центр по профилактике и борьбе со СПИД и инфекционными заболеваниями»15122018184VOL 18, NO4 (2018)ТОМ 18, №4 (2018)71609042019Copyright ©; 2018, Belyakov N.A., Rassokhin V.V., Stepanova E.V., Leonova O.N., Boeva E.V.Copyright ©; 2018, Беляков Н.А., Рассохин В.В., Степанова Е.В., Леонова О.Н., Боева Е.В.2018Belyakov N.A., Rassokhin V.V., Stepanova E.V., Leonova O.N., Boeva E.V.Беляков Н.А., Рассохин В.В., Степанова Е.В., Леонова О.Н., Боева Е.В.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/MAJ/article/view/11680

An analysis of the human immunodeficiency virus (HIV) epidemic’s trajectory with priority-setting taking into account HIV-associated comorbidities for each time period was performed. A classification of comorbid diseases and conditions in HIV infection by cause and setting of their occurrence is presented. Opportunistic infections and secondary diseases that remain some of the leading causes of severe complications and mortality are characterized. The difficulty of the development of immune reconstitution inflammatory syndrome against the background of late diagnosis of HIV infection and initiation of antiretroviral therapy is highlighted.

Произведен анализ эволюции эпидемии ВИЧ-инфекции с формированием приоритетных для каждого периода времени вариантов коморбидности при этом заболевании. Представлена классификация коморбидных состояний при ВИЧ-инфекции по причинам и условиям их развития. Дана общая характеристика оппортунистических инфекций и вторичных патологий, которые остаются одной из лидирующих причин развития тяжелых осложнений и смертности. Рассмотрены основные факторы риска и патогенетические основы развития синдрома восстановления иммунной системы.

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