Medical academic journalMedical academic journalМедицинский академический журнал1608-41012687-1378Eco-Vector1519010.17816/MAJ19146-64Analytical reviewsАналитические обзорыResearch ArticleLactoferrin as a promising remedy for metabolic syndrome therapy: from molecular mechanisms to clinical trialsЛактоферрин как перспективное средство в терапии метаболического синдрома: от молекулярных механизмов до клинических испытаний3059-4381ElizarovaAnna Yu.ЕлизароваАнна Юрьевна
Russian Federation

PhD student, Research fellow of the Department of Molecular Genetics

аспирант, научный сотрудник отдела молекулярной генетики

anechka_v@list.ruhttps://orcid.org/0000-0002-1405-13222726-2921KostevichValeria A.КостевичВалерия Александровна
Russian Federation

PhD (Biology), Senior Researcher of the Department of Molecular Genetics; Research fellow of the Department of Biophysics

канд. биол. наук, старший научный сотрудник отдела молекулярной генетики; научный сотрудник отдела биофизики

hfa-2005@yandex.ruVoynovaIrina V.ВойноваИрина Витальевна
Russian Federation

PhD student, Research fellow of the Department of Molecular Genetics

аспирант, научный сотрудник отдела молекулярной генетики

iravoynova@mail.ruhttps://orcid.org/0000-0001-9033-05377427-7395SokolovAlexey V.СоколовАлексей Викторович
Russian Federation

Doctor of Biological Sciences, Head of the Laboratory of Biochemical Genetics of the Department of Molecular Genetics; Senior Researcher of the Department of Biophysics; Professor of Chair of Fundamental Problems of Medicine and Medical Technology

д-р биол. наук, заведующий лабораторией биохимической генетики отдела молекулярной генетики; старший научный сотрудник отдела биофизики; профессор кафедры фундаментальных проблем медицины и медицинских технологий

biochemsokolov@gmail.comInstitute of Experimental MedicineФГБНУ «Институт экспериментальной медицины»Institute of Experimental MedicineФГБНУ «Институт экспериментальной медицины», Санкт-ПетербургFederal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological AgencyФГБУ «Федеральный научно-клинический центр физико-химической медицины Федерального медико-биологического агентства»Saint Petersburg State UniversityФГБОУ ВПО «Санкт-Петербургский государственный университет»0207201919146640207201902072019Copyright ©; 2019, Elizarova A.Y., Kostevich V.A., Voynova I.V., Sokolov A.V.Copyright ©; 2019, Елизарова А.Ю., Костевич В.А., Войнова И.В., Соколов А.В.2019Elizarova A.Y., Kostevich V.A., Voynova I.V., Sokolov A.V.Елизарова А.Ю., Костевич В.А., Войнова И.В., Соколов А.В.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/MAJ/article/view/15190

The review summarizes data on the effect of the protein present in exocrine secretions and neutrophils, lactoferrin, on components of metabolic syndrome pathogenesis. The molecular mechanisms of lactoferrin participation in the regulation of carbohydrate and lipid metabolism, such as that of lipoproteins, glycated proteins, fatty and bile acids, are contemplated. The influence of lactoferrin on the development of insulin resistance and hypertension, on proliferation of adipocytes, on inflammatory processes and endocrine control is considered. An analysis of population-based studies on the link between lactoferrin gene expression level and metabolic syndrome evidences is carried out. The results of numerous experiments focused on the effects of lactoferrin in metabolic syndrome and obesity animal models are presented. The results of the first international clinical trials aimed to correct obesity and type 2 diabetes mellitus in volunteers are discussed.

В обзоре суммированы данные о влиянии белка экзокринных секретов и нейтрофилов, лактоферрина, на звенья патогенеза метаболического синдрома. Рассматриваются молекулярные механизмы участия лактоферрина в регуляции обмена углеводов и липидов: липопротеинов, гликированных белков, жирных и желчных кислот. Обсуждается влияние лактоферрина на развитие инсулинорезистентности и гипертензии, пролиферацию адипоцитов, воспалительные процессы и гормональную регуляцию. Проведен анализ популяционных исследований о связи экспрессии гена лактоферрина и признаков метаболического синдрома. Приведены результаты многочисленных опытов по оценке действия лактоферрина в моделях развития метаболического синдрома и ожирения у лабораторных животных. Обсуждаются результаты первых зарубежных клинических исследований применения лактоферрина для коррекции ожирения и сахарного диабета 2-го типа у добровольцев.

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