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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="oration" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Medical academic journal</journal-id><journal-title-group><journal-title xml:lang="en">Medical academic journal</journal-title><trans-title-group xml:lang="ru"><trans-title>Медицинский академический журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1608-4101</issn><issn publication-format="electronic">2687-1378</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">19394</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Conference Report, Theses of Report</subject></subj-group></article-categories><title-group><article-title xml:lang="en">COMBINED ACTION OF ANTIMICROBIAL PEPTIDES AND NONIONIC SURFACTANTS TOWARDS BACTERIA</article-title><trans-title-group xml:lang="ru"><trans-title>СОЧЕТАННОЕ ДЕЙСТВИЕ АНТИМИКРОБНЫХ ПЕПТИДОВ И НЕИОНОГЕННЫХ ПОВЕРХНОСТНО-АКТИВНЫХ ВЕЩЕСТВ В ОТНОШЕНИИ БАКТЕРИЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Zharkova</surname><given-names>M S</given-names></name><name xml:lang="ru"><surname>Жаркова</surname><given-names>М С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Orlov</surname><given-names>D S</given-names></name><name xml:lang="ru"><surname>Орлов</surname><given-names>Д С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kolobov</surname><given-names>A A</given-names></name><name xml:lang="ru"><surname>Колобов</surname><given-names>А А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shamova</surname><given-names>O V</given-names></name><name xml:lang="ru"><surname>Шамова</surname><given-names>О В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Experimental Medicine, Saint Petersburg</institution></aff><aff><institution xml:lang="ru">ФГБНУ «Институт экспериментальной медицины»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">State Research Institute of Highly Pure Biopreparations, Saint Petersburg</institution></aff><aff><institution xml:lang="ru">ФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2019-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2019</year></pub-date><volume>19</volume><issue>1S</issue><issue-title xml:lang="en">VOL 19, NO 1S (2019)</issue-title><issue-title xml:lang="ru">ТОМ 19, №1S (2019)</issue-title><fpage>194</fpage><lpage>196</lpage><history><date date-type="received" iso-8601-date="2020-02-06"><day>06</day><month>02</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2019, Zharkova M.S., Orlov D.S., Kolobov A.A., Shamova O.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2019, Жаркова М.С., Орлов Д.С., Колобов А.А., Шамова О.В.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="en">Zharkova M.S., Orlov D.S., Kolobov A.A., Shamova O.V.</copyright-holder><copyright-holder xml:lang="ru">Жаркова М.С., Орлов Д.С., Колобов А.А., Шамова О.В.</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/MAJ/article/view/19394">https://journals.eco-vector.com/MAJ/article/view/19394</self-uri><abstract xml:lang="en"><p>Antimicrobial peptides (AMPs) have certain resemblance with surfactants. Using checkerboard titrations and spectrophotometrical analysis of the membrane permeability for chromogenic markers, we found that nonionic surfactants “Tritons” significantly increase the speed of membranolytic action of AMPs, and enhance their antibacterial activity.</p></abstract><trans-abstract xml:lang="ru"><p>Антимикробные пептиды имеют определенное сходство с поверхностно активными веществами (ПАВ). Методом серийных разведений по схеме «шахматной доски» и путем спектрофотометрического анализа проницаемости мембран для хромогенных маркеров было установлено, что неионогенные ПАВ «Тритоны» существенно ускоряют мембранолитическое действие АМП и повышают их антибактериальную активность.</p></trans-abstract><kwd-group xml:lang="en"><kwd>antimicrobial peptides</kwd><kwd>Triton X</kwd><kwd>synergy</kwd><kwd>antibacterial action</kwd><kwd>membrane permeabilization</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>антимикробные пептиды</kwd><kwd>тритон Х</kwd><kwd>синергизм</kwd><kwd>антибактериальное действие</kwd><kwd>проницаемость мембран</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Antibacterial peptide protocols / W. Shafer (ed.). Totowa, NJ: Humana Press Inc., 1998. 255 p.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Orhan G, et al. Synergy Tests by E Test and Checkerboard Methods of Antimicrobial Combinations against Brucella melitensis. J. Clin. Microbiol. 2005;43(1):140-143.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Lehrer R, et al. Concurrent assessment of inner and outer membrane permeabilization and bacteriolysis in E. coli by multiple-wavelength spectrophotometry. J. Immunol. Methods. 1988;108:153-158.</mixed-citation></ref></ref-list></back></article>
