Medical academic journalMedical academic journal1608-41012687-1378Eco-Vector2574610.17816/MAJ25746Review ArticleNeurodegenerative and metabolic disorders, mediated by the trace amines and their receptorsApryatinSergey A.<p>PhD, Senior Scientific Researcher, Pavlov Department of Physiology</p>apryatin@mail.ruhttps://orcid.org/0000-0002-6543-7495KarpenkoMarina N.<p>PhD (Biology), Senior Researcher of The Pavlov Department of Physiology</p>mnkarpenko@mail.ruhttps://orcid.org/0000-0002-1082-0059MuruzhevaZamira M.<p>Research Worker, Pavlov Department of Physiology</p>zamira.muruzheva@mail.ruBolshakovaMaria V.<p>Trainee, Pavlov Department of Physiology</p>bolshakova.masha37@gmail.comhttps://orcid.org/0000-0001-5766-4172MagazenkovaDaria N.<p>Trainee, Pavlov Department of Physiology</p>magdash@mail.ruhttps://orcid.org/0000-0003-1959-7110KlimenkoVictor M.<p>MD, PhD, Professor, Head of the Pavlov Department of Physiology</p>klimenko_victor@mail.ruhttps://orcid.org/0000-0001-9701-4537Institute of Experimental Medicine220620202019221603202018032020Copyright © 2020, Apryatin S.A., Karpenko M.N., Muruzheva Z.M., Bolshakova M.V., Magazenkova D.N., Klimenko V.M.2020<p>The aim of the study is the modern scientific literature estimation in the field of the investigation of neurodegenerative and metabolic disorders mediated by the trace amines and their receptors. The analysis of modern ideas about the feedback of neurodegenerative and metabolic diseases in which the trace amines and their receptors are involved was carried out. The important role of trace amines and their receptors in the regulation of the dopamine system, in connection with metabolic and neurodegenerative diseases, including Parkinsons disease, ADHD, schizophrenia, obesity, metabolic syndrome and other pathological conditions, has been shown. Trace amines and their receptors have a direct effect on dopamine systems, being regulators of various metabolic and neurodegenerative processes, participating in energy metabolism, neurogenesis, and other vital processes.</p>trace aminesneurodegenerative and metabolic diseasestrace amines receptorsследовые аминынейродегенеративные и метаболические заболеваниярецепторы следовых аминов[Premont RT, Gainetdinov RR, Caron MG. Following the trace of elusive amines. 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