Medical academic journalMedical academic journalМедицинский академический журнал1608-41012687-1378Eco-Vector693677Clinical medicineКлиническая медицинаResearch ArticleThe molecular-genetic research of gap junction intercellular communications in colorectal cancerМолекулярно-генетические исследования межклеточных щелевых контактов при колоректальном ракеIatckiiN. A.ЯицкийН. А.
Russian Federation

член-корреспондент РАМН

shabanov@mail.rcom.ruVasil'evS. V.ВасильевС. В.
Russian Federation
shabanov@mail.rcom.ruPopovD. E.ПоповД. Е.
Russian Federation
shabanov@mail.rcom.ruDubinaM. V.ДубинаМ. В.
Russian Federation
shabanov@mail.rcom.ruI. I. Pavlov State Medical UniversityСанкт-Петербургский государственный медицинский университет им. академика И. П. Павлова310820033388951710202517102025Copyright ©; 2003, Eco-VectorCopyright ©; 2003, Эко-Вектор2003Eco-VectorЭко-Векторhttps://journals.eco-vector.com/MAJ/article/view/693677

This article presents the comparative analysis of perspectives in the field of molecular-genetic research of gap junction intercellular communications (GJIC) in colorectal cancer and other malignant tumors. The current investigations are characterized by profound theoretical studies and experimental research of GJIC antitumor properties. Special interest is rewarding to in vitro and in vivo experiments showed that different cancer cells transfected with GJIC-connexin genes reduced their tumorigenicity significantly. Some somatic connexin gene mutations were recently been revealed at the late stage of sporadic human colorectal cancer. This fact let us suggest that more detail molecular-genetic investigations of connexin genes in malignant tumors further could be a perspective line of cancer research. The results of the investigations could be demanded for the development of early diagnosis and gene therapy of malignant diseases.

В статье проводится сравнительный анализ перспектив молекулярно-генетических исследований межклеточных щелевых контактов (МЩК) при раке толстой кишки и других злокачественных заболеваниях на основе сопоставления литературных данных с собственными результатами авторов. Состояние этих исследований в настоящее время характеризуется глубоким теоретическим изучением и экспериментальными подтверждениями противопухолевых свойств МЩК. Особый интерес вызывают эксперименты in vitro и in vivo, свидетельствующие о снижении опухолеродности различных злокачественных клеток при трансфекции в них коннексинов - структурных белков межклеточных щелевых контактов. Недавно были обнаружены соматические мутации гена коннексина-43 на стадии прогрессии спорадического рака толстой кишки у человека. Это позволяет предположить, что дальнейшие углубленные молекулярные исследования коннексинов в злокачественных опухолях являются перспективным направлением в изучении патогенеза новообразований. Результаты таких исследований будут востребованы для разработки методов ранней диагностики и генной терапии онкологических заболеваний.

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