Medical academic journalMedical academic journalМедицинский академический журнал1608-41012687-1378Eco-Vector8359410.17816/MAJ83594Analytical reviewsАналитические обзорыReview ArticleMolecular mechanisms of drug resistance of glial tumor of brain. Part 2: Proliferation, angiogenesis, metastasis and recurrencyМолекулярные механизмы лекарственной устойчивости глиальных опухолей мозга. Часть 2. Пролиферация, ангиогенез, метастазирование и рецидивированиеhttps://orcid.org/0000-0003-2464-7370ChernovAlexander N.ЧерновАлександр Николаевич
Russian Federation

PhD, Cand. Sci. (Biol.), Research Associate, Department of General Pathology and Pathological Physiology

канд. биол. наук, научный сотрудник отдела общей патологии и патологической физиологии

al.chernov@mail.ruhttps://orcid.org/0000-0002-8773-093224331659400GalimovaElvira S.ГалимоваЭльвира Сафуановна
Russian Federation

PhD, Cand. Sci. (Biol.), Senior Researcher; Senior Researcher

канд. биол. наук, старший научный сотрудник; старший научный сотрудник

elya-4@yandex.ruhttps://orcid.org/0000-0002-5168-28016603643804F-6743-2013ShamovaOlga V.ШамоваОльга Валерьевна
Russian Federation

Dr. Sci. (Biol.), Assistant Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of General Pathology and Pathological Physiology; Professor of the Department of Biochemistry

д-р биол. наук, доцент, член-корреспондент РАН, заведующий отделом общей патологии и патологической физиологии; профессор кафедры биохимии

oshamova@yandex.ruInstitute of Experimental MedicineИнститут экспериментальной медициныSechenov Institute of Evolutionary Physiology and Biochemistry Russian Academy of SciencesИнститут эволюционной физиологии и биохимии им. И.М. Сеченова РАНSaint Petersburg State UniversityСанкт-Петербургский государственный университет2806202219072022221891172310202129052022Copyright ©; 2022, Chernov A.N., Galimova E.S., Shamova O.V.Copyright ©; 2022, Чернов А.Н., Галимова Э.С., Шамова О.В.2022Chernov A.N., Galimova E.S., Shamova O.V.Чернов А.Н., Галимова Э.С., Шамова О.В.https://creativecommons.org/licenses/by-nc-nd/4.0https://journals.eco-vector.com/MAJ/article/view/83594

The main reason for the low efficiency of glioblastoma therapy is its resistance to therapeutic procedures. The development of multidrug resistance occurs as a result of the selection of tumor clones during therapy. The resistant cell clones to radiotherapy and chemotherapy can proliferate, leading to tumor growth, in which its own vascular network is formed (angiogenesis), which promotes cell migration, invasion and the appearance of metastases and recurrent glioblastoma. The review examines the relationship at the molecular level of multidrug resistance with proliferation, angiogenesis, migration, metastasis, and the formation of glioblastoma relapses, with an emphasis on identifying new targets among proteins, microRNAs, signal transduction kinases, transcription factors, tumor-supressor genes and oncogenes.

Главная причина низкой эффективности лечения глиобластомы — ее устойчивость к терапевтическим процедурам. Развитие множественной лекарственной устойчивости происходит в результате отбора опухолевых клонов во время терапии. Резистентные к радиотерапии или химиотерапии клоны клеток могут пролиферировать, приводя к росту опухоли, в которой образуется собственная сеть сосудов (ангиогенез), способствующая миграции и инвазии клеток, и, как следствие, появлению метастазов и рецидивов глиобластомы. В обзоре рассмотрена взаимосвязь на молекулярном уровне множественной лекарственной устойчивости с пролиферацией, ангиогенезом, миграцией, метастазированием и образованием рецидивов глиобластомы с акцентом на выявлении новых мишеней среди белков, микроРНК, киназ сигнальной трансдукции, транскрипционных факторов, генов-супрессоров и онкогенов.

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