Medical academic journalMedical academic journalМедицинский академический журнал1608-41012687-1378Eco-Vector8758210.17816/MAJ87582Analytical reviewsАналитические обзорыReview ArticleCoumarins as a base for the drug development: yes or no?Кумарины как основа для разработки лекарственных веществ: да или нет?https://orcid.org/0000-0002-0999-82125568-8939LitasovaElena V.ЛитасоваЕлена Викторовна
Russian Federation

Cand. Sci. (Biol.), Leading Research Associate of the Laboratory of Drug Design and Nanotechnology, Department of Neuropharmacology

канд. биол. наук, ведущий научный сотрудник лаборатории синтеза и нанотехнологий лекарственных веществ отдела нейрофармакологии им. С.В. Аничкова

llitasova@mail.ruhttps://orcid.org/0000-0002-1012-75615559-8089IljinViktor V.ИльинВиктор Владимирович
Russian Federation

Cand. Sci. (Chem.), Research Associate of the Laboratory of Drug Design and Nanotechnology, Department of Neuropharmacology

канд. хим. наук, научный сотрудник лаборатории синтеза и нанотехнологий лекарственных веществ, отдела нейрофармакологии им. С.В. Аничкова

victor.iljin@mail.ruhttps://orcid.org/0000-0002-0863-3027MyznikovLeonid V.МызниковЛеонид Витальевич
Russian Federation

Dr. Sci. (Chem.), Research Associate, Department of Neuropharmacology

д-р хим. наук, научный сотрудник отдела нейрофармакологии им. С.В. Аничкова

postleo@mail.ruhttps://orcid.org/0000-0001-8433-120X8953-8772BrusinaMaria A.БрусинаМария Александровна
Russian Federation

Cand. Sci. (Chem.), Junior Research Associate of the Laboratory of Drug Design and Nanotechnology, Department of Neuropharmacology

канд. хим. наук, младший научный сотрудник лаборатории синтеза и нанотехнологий лекарственных веществ, отдела нейрофармакологии им. С.В. Аничкова

mashasemen@gmail.comhttps://orcid.org/0000-0001-8679-13652927-6178PiotrovskiyLevon B.ПиотровскийЛевон Борисович
Russian Federation

Dr. Sci. (Biol.), Head of the Laboratory Drug Design and Nanotechnology, Department of Neuropharmacology

д-р биол. наук, заведующий лабораторией синтеза и нанотехнологий лекарственных веществ отдела нейрофармакологии им. С.В. Аничкова

levon-piotrovsky@yandex.ruInstitute of Experimental MedicineФГБНУ «Институт экспериментальной медицины»190320221212202222327361111202119032022Copyright ©; 2022, Eco-VectorCopyright ©; 2022, Эко-Вектор2022Eco-VectorЭко-Векторhttps://journals.eco-vector.com/MAJ/article/view/87582

It is well known that coumarin derivatives are widely distributed in nature and have a wide spectrum of biological activity. At the same time, only a few compounds containing a coumarin fragment are used in the clinics. These compounds include for example the anticoagulant warfarin and the anthelmintic drug haloxon. In the present article is discussed the few examples of biological activity of coumarin derivatives, the mechanisms of action of these compounds and the problems that arise in the development of new drugs, as well as the prospects for using coumarins as leader compounds.

Известно, что кумарины обладают широким спектром биологической активности. Однако применение в клинике нашли лишь отдельные их производные (например, антикоагулянт варфарин и глистогонный препарат галоксон). В настоящей статье на ряде примеров рассматриваются биологическая активность производных кумарина, механизмы действия этих соединений и проблемы, возникающие при разработке новых лекарственных препаратов, а также перспективы использования кумаринов как соединений-лидеров.

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