Medical academic journalMedical academic journalМедицинский академический журнал1608-41012687-1378Eco-Vector980910.17816/MAJ14419-32ArticlesСтатьиResearch ArticleA TRIBUTE TO ELENA KORNEVA, A PIONEER OF NEUROIMMUNE BIOLOGY, ON HER 85 th BIRTHDAYЕЛЕНЕ КОРНЕВОЙ - ПИОНЕРУ НЕЙРОИММУНОЛОГИИ, В ДЕНЬ ЕЕ 85-ЛЕТИЯ ПОСВЯЩАЕТСЯBercziIstvanБерциИштван

Department of Immunology; Departamento de Fisiologia y Farmacologia, Centro de Ciencias Basicas

Отдел иммунологии; Кафедра физиологии и фармакологии, Центр фундаментальных наук

Berczii@ms.umanitoba.caUniversity of ManitobaУниверситет МанитобыUniversidad Autónoma de AguascalientesАвтономный университет Агуаскальентес15122014144VOL 14, NO4 (2014)ТОМ 14, №4 (2014)193203092018Copyright ©; 2014, Berczi I.Copyright ©; 2014, Берци И.2014Berczi I.Берци И.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/MAJ/article/view/9809

The scientific carrier of Elena Korneva is presented, who dedicated her life for research on Immuno-Physiology, as she likes to call her field. PubMed reports 102 papers over 52 years. We can safely assume that her total production, including those works, which are not reported by PubMed might be over 200-250 papers, books and book chapters. We discuss a total of 70 papers, as for many papers only the titles were available to us. Of this 70 papers 55 were reported by PubMed between 1962 and 2009. In addition we have collected 14 papers and one book which were not reported by PubMed. These are book chapters and journal articles. Her research subjects vary a great deal, but everything has to do with Immuno-Physiology. The first paper we discuss establishes that the hypothalamus regulates immune function [1]. This knowledge that the Neuroendocrine and Immunes Systems interact never was neglected in her papers. Here we list the various fields of her investigations and put the reference numbers in brackets to help the reader. Neuroimmune interaction [References No.: 1, 5-12]; Glucocorticoids [13-15]; Cytokines [13-25]; Defensins [26, 27, 55]; Signal Transduction [29-31]; Stress [31-37]; Cholinergic immunoregulation [38, 39]; Opioid peptides [40]; Thymus [41]; Pineal gland [42]; Natural killer (NK) cells [43]; Anesthesia [44]; Nonspecific resistance [45]; Autoimmunity [46, 47]; Chronic fatigue syndrome (CFS) [48]. Orexin and immunity [49-52]; History of Neuroimmune Biology [54]; Concluding remarks to NIB 6 [55]; Immune response in the CNS [56]. Signal Transduction by IL-1 and IL-2 [57, 58]. c-Fos gene and Il-2 expression in the brain [59]; Signaling mechanisms in stress [60]. Orexin in the CNS and in immune organs [61, 62]. Neuroimmune pathology of stress [63]. As we may see Korneva covered just about any subjects belonging to Immuno-Physiology. She is a leader, not a follower, so all of the papers present new discoveries, new aspects of various areas of the subject matter she investigated. Considering this fact and also the work that could not be reported here makes her a truly outstanding scientist, which has been appreciated by various institutions. She received numerous medals and awards and fulfilled leading positions for a lifetime.

В обзоре представлена научная карьера Елены Корневой, которая посвятила свою жизнь исследованиям проблем иммунофизиологии. В базе PubMed находятся 102 ее работы за более чем 52 года ее деятельности, но можно с уверенностью сказать, что у нее гораздо больше научных публикаций (статей, монографий, глав из книг). Настоящий обзор охватывает в общей сложности 70 статей. Из этих 70 статей 55 зарегистрированы в базе PubMed и были опубликованы между 1962 и 2009 г. Кроме того, мы выбрали еще 14 журнальных статей и одну книгу, которые оказались вне поля зрения PubMed. Научные интересы Е. Корневой разнообразны, но все имеют отношение к иммунофизиологии. В статье 1963 года, с обсуждения которой начинается обзор, были приведены доказательства, что гипоталамус участвует в регуляции функций иммунной системы [ 1 ]. Это положение о взаимодействии нейроэндокринной и иммунной систем, красной нитью проходит во всех ее работах. Исследования Е. Корневой распространяются практически на все направления, относящиеся к иммунофизиологии, в частности такие, как нейроиммунные взаимодействия [1, 5-12]; глюкокортикоидные гормоны [13-15]; цитокины [13-26]; дефенсины [27, 28, 56]; сигнальная трансдукция [30-32]; стресс [33-39]; холинергическая иммунорегуляция [40, 41]; опиоидные пептиды [42]; ти мус [43] ; шишковидная железа [44]; NK-клетки [45]; анестезия [46]; неспецифическая резистентность [47]; аутоиммунные заболевания [48, 49]; синдром хронической усталости (CFS) [50]; орексин и иммунитет [51-54]; история нейроиммунологии [56]; иммунный ответ в ЦНС [58]; сигнальная трансдукция ИЛ-1 и ИЛ-2 [59, 60], экспрессия генов с-Fos и ИЛ-2 в мозге [61]; сигнальные механизмы стресса [62]; орексин в ЦНС и в ор га нах им мун ной си с те мы [63, 64]. Главное, что объединяет все ее исследования - эти работы представляют собой открытия в области иммунофизиологии, раскрывают новые стороны исследуемого предмета. Это делает Елену Корневу по-настоящему выдающимся ученым, ее заслуги оценены различными научными организациями. Она получила многочисленные медали и награды и заслуженно заняла лидирующую позицию в науке.

Korneva E. A., Khai L. M. Effect of destruction of areas of the hypothalamic region on the process of immunogenesis // Fiziol Zh SSSR Im I M Sechenova.- 1963.- Vol. 49.- P. 42-48.Korneva, History of Nib. See ref 57.Korneva, Editor Nib6. see Ref. No. 56.Korneva E. A. Immunophysiology as a new scientific discipline // Fiziol Zh Im I M Sechenova.- 1994.- Vol. 80.- P. 116-124.Gushchin G. V., Grigor’ev V. A., Platteau B., Bazin H., Korneva E. A. Immunohistochemical analysis of splenic tissue in rats with destruction of the hypothalamic structures // Biull Eksp Biol Med.- 1989.- Vol. 107.- P. 319-322.Korneva E. A., Bychkov E. R. Monoamines in the hypothalamic structures in the first few hours after immunization // Vestn Ross Akad Med Nauk.- 1992.- Vol. 7.- P. 25-28.Korneva E. A., Barabanova S. V., Golovko O. I., Nosov M. A., Novikova N. S., Kazakova T. B. C-fos and IL-2 gene expression in rat brain cells and splenic lymphocytes after nonantigenic and antigenic stimuli // Ann N Y Acad Sci.- 2000.- Vol. 917.- P. 197-209.Nosov M. A., Barabanova S. V., Glushikhina M. S., Kazakova T. B., Korneva E. A. Cell activation in the hypothalamus after exposure to an antigen (based on c-fos gene expression). Ross Fiziol Zh Im IM Sechenova.- 2001.- Vol. 87.- P. 331-340. [Article in Russian]Nosov M.A., Barabanova S. V., Glushikhina M. S., Kazakova T. B., Korneva E.A. Antigen-induced activation of hypothalamic cells (assessed by expression of the c-fos gene) // Neurosci Behav Physiol.- 2002.- Vol. 32.- P. 523-528.Kazakova T. B., Barabanova S. V., Novikova N. S., Glushikhina M. S., Khavinson V. Kh., Malinin V. V., Korneva E. A. Synthesis of IL-2 mRNA in cells of rat hypothalamic structures after injection of short peptides // Bull Exp Biol Med.- 2005.- Vol. 139.- P. 718-720.Gavrilov Y. V., Perekrest S.V., Novikova N. S., Korneva E. A. Stress-induced changes in cellular responses in hypothalamic structures to administration of an antigen (lipopolysaccharide) (in terms of c-Fos protein expression) // Neurosci Behav Physiol.- 2008.- Vol. 38 (2).- P. 189-194.Perekrest S. V., Abramova T. V., Novikova N. S., Loskutov Y. V., Rogers V. J., Korneva E. A. Changes in immunoreactivity of orexin-A-positive neurons after intravenous lipopolysaccharide injection // Med Sci Monit.- 2008.- Vol. 14.- P. 127-133.Shkhinek E. K., Korneva E. A., Stark E., Acs Zs., Abavary K. Glucocorticoid hormones and the immune response // Fiziol Zh SSSR Im I M Sechenova.- 1984.- Vol. 70 (2).- P. 213-220.Korneva E. A., Shkhinek E. K. Hypothalamo-hypophyseal-adrenal system in the regulation of immunologic processes // Fiziol Zh SSSR Im I M Sechenova.- 1984.- Vol. 70 (9).- P. 1286-1293.Rybakina E. G., Salai K., Korneva E. A., Shkhinek E. K., Lesnikova M. P. The mechanism of the effect of interleukin-1 on the glucocorticoid level of the blood: the absence of a direct action of interleukin-1 on adrenal cortex cells // Probl Endokrinol (Mosk).- 1990.- Vol. 36.- P. 73-76.Lesnikov V. A., Efremov O. M., Korneva E. A., Van Damme J., Billiau A. Fever produced by intrahypothalamic injection of interleukin-1 and interleukin-6 // Cytokine.- 1991.- Vol. 3.- P. 195-198.Korneva E. A., Rybakina E. G., Orlov D. S., Shamova O. V., Shanin S. N., Kokryakov V. N. Interleukin-1 and defensins in thermoregulation, stress, and immunity // Ann N Y Acad Sci.- 1997.- Vol. 813.- P. 465-473.Rybakina E. G., Fomicheva E. E., Pivanovich I. Iu., Korneva E. A. Effect of modification of the structure of interleukin-1beta on its physiological activity // Ross Fiziol Zh Im IM Sechenova.- 1999.- Vol. 85.- P. 1420-1427.Rybakina E. G., Nalivaeva N. N., Pivanovich I. Iu., Shanin S. N., Kozinets I. A., Korneva E. A. The role of neutral sphingomyelinase in the inter-leukin-1beta signal transduction in cells of the mouse cerebral cortex // Ross Fiziol Zh Im I M Sechenova.- 2000.- Vol. 86.- P. 303-311.Kazakova T. B., Barabanova S. V., Novikova N. S., Nosov M. A., Rogers V. V., Korneva E.A. Induction of c-fos and interleukin-2 genes expression in the central nervous system following stressor stimuli // Pathophysiology.- 2000.- Vol. 7.- P. 53-61.Khavinson V. K., Morozov V. G., Malinin V. V., Kazakova T. B., Korneva E. A. Effect of peptide Lys-Glu on interleukin-2 gene expression in lymphocytes // Bull Exp Biol Med.- 2000.- Vol. 130 (9).- P. 898-900.Rybakina E. G., Nalivaeva N. N., Pivanovich Y. U., Shanin S. N., Kozinets A., Korneva E. A. The role of neutral sphingomyelinase in inter-leukin-1beta signal transduction in mouse cerebral cortex cells // Neurosci Behav Physiol.- 2001.- Vol. 31.- P. 439-444.Kazakova T. B., Barabanova S. V., Khavinson V. Kh., Glushikhina M. S., Parkhomenko E. P., Malinin V. V., Korneva E. A. In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes // Bull Exp Biol Med.- 2002.- Vol. 133.- P. 614-616.Barabanova S. V., Artiukhina Z.E., Ovchinnikova K. T., Abramova T. V., Kazakova T. B., Khavinson V. Kh., Malinin V. V., Korneva E.A. Parallel analysis of c-Fos protein and interleukin-2 expression in hypothalamic cells under different influence / / Ross Fiziol Zh Im IM Sechenova.- 2007.- Vol. 93.- P. 150-160.Ashmarin I. P., Tkachenko S. B., Rud'ko I.A., Korneva E. A., Kokriakov V. N., Kubatiev A. A. Effect of defensin on platelet functional activity // Biull Eksp Biol Med.- 1993.- Vol. 115.- P. 23-25.Shamova O. V., Lesnikova M. P., Kokriakov V. N., Shkhinek E. K., Korneva E. A. The action of defensins on the corticosterone level of the blood and on the immune response in stress // Biull Eksp Biol Med.- 1993.- Vol. 115.- P. 646-649.Tkachenko S. B., Fesenko O. V., Korneva E. A., Ashmarin I. P., Kubatiev A. A. Human neutrophilic defensin modulates the functional activity of the monocytes // Biull Eksp Biol Med.- 1993.- Vol. 116.- P. 474-476.Rybakina E. G., Korneva E. A. Interleukin-1 signal transduction in interaction between the nervous and immune systems // Vestn Ross Akad Med Nauk.- 2005.- Vol. (7).- P. 3-8.Pivanovich I. Iu., Rybakina E. G., Fomicheva E. E., Korneva E. A. The role of glucocorticoid hormones in interleukin-1 signal transduction via the sphingomyelin pathway // Ross Fiziol Zh Im I M Sechenova.- 2004.- Vol. 90 (6).- P. 781-789.Novikova N. S., Kazakova T. B., Rogers V., Korneva E. A. C-fos gene expression in the rat spinal cord and brain cells during stress and the use of different types of halothane anesthesia // Ross Fiziol Zh Im I M Sechenova.- 2002.- Vol. 88 (11).- P. 1378-1387.Korneva E. A., Shanin S. N., Rybakina E. G. The role of interleukin-1 in stress-induced changes in immune system function // Neurosci Behav Physiol.- 2001.- Vol. 31.- P. 431-437.Korneva E. A., Rybakina E. G., Fomicheva E. E., Kozinets I. A., Shkhinek E. K. Altered interleukin-1 production in mice exposed to rotation stress // IntJ Tissue React.- 1992.- Vol. 14 (5).- P. 219-224.Rybakina E. G., Shanin S. N., Kozinets I. A., Fomicheva E. E., Korneva E. A. Cellular mechanisms of cold stress-related immunosuppression and the action of interleukin 1 // Int J Tissue React.- 1997.- Vol. 19.- Р. 135-140.Novikova N. S., Kazakova T. B., Rogers V. J., Korneva E. A. C-fos gene expression induced in cells in specific hypothalamic structures by noxious mechanical stimulation and its [correction of it’s] modification by exposure of the skin to extremely high frequency irradiation / / Neuro Endocrinol Lett.- 2002.- Vol. 23 (4).- P. 315-320.Khavinson V. Kh., Korneva E. A., Malinin V. V., Rybakina E. G., Pivanovich I. Y., Shanin S. N. Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress // Neuro Endocrinol Lett.- 2002.- Vol. 23.- P. 411-416Gavrilov Y. V., Perekrest S. V., Novikova N. S., Korneva E. A. Stress-induced changes in cellular responses in hypothalamic structures to administration of an antigen (lipopolysaccharide) (in terms of c-Fos protein expression) // Neurosci Behav Physiol.- 2008.- Vol. 38 (2).- P. 189-194.Gushchin G. V., Jakovleva E. E., Kataeva G. V., Korneva E. A., Gajewski M., Grabczewska E., Laskowska-Bozek H., Maslinski W., Ryzewski J. Muscarinic cholinergic receptors of rat lymphocytes: effect of antigen stimulation and local brain lesion // Neuroimmunomodulation.- 1994.- Vol. 1.- P. 259-264.Gushchin B. V., Khaidarova D. S., Kugusheva L. I., Rozengart V. I., Korneva E. A. The lymphocyte acetylcholinesterase activity in rats poisoned by pesticides // Biull Eksp Biol Med.- 1991.- Vol. 111.- P. 144-146.Gritskevich N. L., Korneva E. A. The participation of opioid peptides in forming the nonspecific protective reactions of the body // Biull Eksp Biol Med.- 1993.- Vol. 116.- P. 381-384.Khavinson V. Kh., Rybakina E. G., Malinin V. V., Pivanovich I. Y., Shanin S. N., Korneva E. A. Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway // Bull Exp Biol Med.- 2002.- Vol. 133.- P. 497-499.Lesnikov V. A., Korneva E. A., Dall’ara A., Pierpaoli W. The involvement of pineal gland and melatonin in immunity and aging: II. Thyrotropin-releasing hormone and melatonin forestall involution and promote reconstitution of the thymus in anterior hypothalamic area (AHA)-lesioned mice // IntJ Neurosci.- 1992.- Vol. 62.- P. 141-153.Rybakin E. G., Novikova N. S., Abramova T. V., Shanin S. N., Kozinets I. A., Rogers V., Korneva E. A. Expression of the c-Fos gene in hypothalamic cells and cytotoxic activity of natural killer cells in the spleen of rats after treatment with Cytoxan // Bull Exp Biol Med.- 2006.- Vol. 141 (4).- P. 394-396.Novikova N. S., Kazakova T. B., Rogers V., Korneva E. A. Expression of the c-fos gene in spinal cord and brain cells in rats subjected to stress in conditions of exposure to various types of halothane anesthesia. Neurosci Behav Physiol.- 2004.- Vol. 34.- P. 407-412.Gritskevich N. L., Gushchin G. V., Katsnel’son Ia. S., Korneva E. A., Lebedev V. P., Lobzhanidze N. Sh., Fomicheva E. E. Nonspecific resistance of the body to transcranial electric stimulation in the analgesia regimen // Patol Fiziol Eksp Ter.- 1991.- Vol. 6.- P. 10-12.Cupić D., Krzalić L. J., Nastić-Mirić D., Korneva E. A., Shkhinek E. Endocrine and metabolic mechanisms of the pathological syndrome due to antigens of homologous glial tissue in monkeys // Biull Eksp Biol Med.- 1984.- Vol. 98.- P. 666-668.Nosov M. A., Fluegel A., Korneva E.A. In search of the guilty: analysis of encephalitogenic T-cell migration pathways on preclinical phase of EAE after their intravenous or intraperitonealinjection // Ross Fiziol Zh Im IM Sechenova.- 2009.- Vol. 95 (12).- P. 1416-1426.Rybakina E. G., Shanin S. N., Fomicheva E. E., Korneva E. A. Cellular and molecular mechanisms of interaction between the neuroendocrine and immune systems under chronic fatigue syndrome in experiment // Ross Fiziol Zh Im IM Sechenova.- 2009.- Vol. 95.- P. 1324-1335.Kazakova T. B., Novikova N. S., Korneva E. A. Structure and functions of the brain orexin-containing neurons // Ross Fiziol Zh Im I M Sechenova.- 2006.- Vol. 92 (6).- P. 677-691.Abramova T. V., Novikova N. S., Perekrest S. V., Rogers V. J., Korneva E. A. Responses of hypothalamic orexin-containing neurons to cyclophosphamide, EHF-irradiation of the skin, and their combination in rats // Pathophysiology.- 2007.- Vol. 14.- P. 79-85.Novikova N. S., Perekrest S. V., Shainidze K. Z., Korneva E. A. Response of hypothalamic orexin-containing neurons to stimuli of antigen and non-antigen nature // Ross Fiziol Zh Im I M Sechenova.- 2009.- Vol. 95.- P. 1309-1323.Perekrest S. V., Shainidze K. Z., Loskutov Iu. V., Abramova T. V., Novikova N. S., Korneva E. A. Immunoreactivity of hypothalamic orexin neurons and expression level of preproorexin gene in them after lipopolysaccharide injection // Ross Fiziol Zh Im IM Sechenova.- 2011.- Vol. 97.- P. 573-579.Abramova T. V., Perekrest S. V., Shainidze K. Z., Novikova N. S., Korneva E. A. Receptors for orexins: structure, localisation and activation mechanisms // Ross Fiziol Zh Im I M Sechenova.- 2011.- Vol. 97.- P. 995-1007.Korneva E. A., Kokryakov V. N. Defensins: Antimicrobial peptides with a broad spectrum of biological activity // The Immune-Neuroendocrine Circuitry: History and Progress. Berczi I, Szentivanyi A. Serial eds. // Neuroimmune Biol.- 2002.- Vol. 3.Phelps C., Korneva E., eds. Berczi I., Szentivanyi A. Serial Eds. Cytokines and the Brain // Neuroimmuine Biol.- 2008.- Vol. 6.Koneva E. A. Concluding Remarks // Cytokines and the brain. Phelps C, Korneva E. Editors, Berczi I, Szentivanyi A. Serial Eds. // Neuroimmuine Biology.- 2008.- Vol. 6.- Р. 567-570.Rybakina E. G., Korneva E.A. Interleukin-1-beta Signal Transduction via the Sphingomyelin Pathway in Brain Cells // Cytokines and the brain. Phelps C., Korneva EA, Editors, Berczi I, Szentivanyi A. Serial Eds. // Neuroimmuine Biol.- 2008.- Vol. 6.- Р. 79-107.Korneva E. A., Kazakova T. B. Interleukin-2 Gene Expression in CNS Cells after Stress and Antigen Application // Cytokines and the brain. Phelps C., Korneva E. Editors, Berczi I, Szentivanyi A. Serial Eds. // Neuroimmuine Biol.- 2008.- Vol. 6.- Р. 353-372.Korneva E. A., Novikova N. S. Brain Responses to Antigenic Challenges. In the brain and host defense. BG. Arnason Ed., Berczi I and Szentivanyi A. Series Ed // NeuroImmune Biol.- 2010.- Vol. 9.- Р. 113-121.Korneva E. A. On the History of Immunophysiology: First Steps and Main Trends. In New Insights to Neurimmune Biology. Berczi I. ed.- Amsterdam: Elsevier, 2010.- Р. 33-50.Perekrest S. V., Shainidze K. Z., Novikova N. S., Kazakova T. B., Korneva E.A. Hypothalamic neuron activation under stress and during antigen application // Adv. Neuroimm. Biol.- 2012.- Vol. 3.- Р. 243-253.Rybakina E. G., Shanin S. N., Korneva E. A. Cellular, Molecular and Signaling Mechanisms in Neuro-Immmune Interactions Under Stress // Adv. Neuroimm. Biol.- 2012.- Vol. 3.- Р. 235-241.Novikova N. S., Korneva E. A. Orexin - Containing Neurons and the Immune System. In the brain and host defense. BG. Arnason Ed., Berczi I. and Szentivanyi A. Series Ed. // NeuroImmune Biol.- 2010.- Vol. 9.- Р. 91-100.Shainidze K. Z., Perekrest S. V., Novikova N. S., Kazakova T. B., Korneva E. A. Stimulation of orexinergic system in the CNS and in immune organs by various forms of stress // Adv. Neuroimm. Biol.- 2012.- Vol. 3.- Р. 255-264.Perekrest S. V., Shteintcaig A. D., Kawakami Naoto, Wekerle Hartmut, Korneva E. A. Morpho-functional characteristics of hypothalamic orex-in neurons during experimental autoimmune encephalomyelitis // Advances of Neuroim. Biol. (in press).Rybakina E. G., Shanin S. N., Formicheva E. E., Dmitrienko E. V., Filatenkova T. A., Korneva E. A. Correction of Stress-induced Dysfunctions of the Immune and Neuroendocrine Systems by Peptide and Nucleotide Preparations // Adv. Neuroim. Biol. 2012; 3 - Р. 353-360.Korneva E. A, Novikova N. C., Perecrest S. V., Shainadze K. Z., Mazina V. A. Neurimmuno-Physiolology - Contemporary and historical cosiderations // Russian J. of Immunology.- 2014.- Vol. 8.- Р. 446-449.