Features of the dynamics of inflammation and apoptosis markers in patients with different acute post-stroke period
| Dublin Core | PKP Metadata Items | Metadata for this Document | |
| 1. | Title | Title of document | Features of the dynamics of inflammation and apoptosis markers in patients with different acute post-stroke period |
| 2. | Creator | Author's name, affiliation, country | S A Zozulya; Mental Health Research Center, Moscow |
| 2. | Creator | Author's name, affiliation, country | I N Otman; Mental Health Research Center, Moscow |
| 2. | Creator | Author's name, affiliation, country | A S Chukanova; Pirogov Russian Research University, Moscow |
| 2. | Creator | Author's name, affiliation, country | T P Klyushnik; Mental Health Research Center, Moscow |
| 3. | Subject | Discipline(s) | |
| 3. | Subject | Keyword(s) | ischemic stroke; leukocyte elastase; a1-proteinase inhibitor; p53 protein; Bcl-2 protein |
| 4. | Description | Abstract | The purpose of this was to study the dynamics of markers of inflammation and apoptosis in the serum of patients with ischemic stroke in the early post-stroke period. Materials and methods. The study involved 22 patients (mean age 60 ± 5.5 years) with different dynamics of neurological symptoms in the acute post-stroke period. Patients were examined twice: on the 1st and 10th day of observation. Quantitative assessment of the severity of neurological deficit using ESS and NIHSS scales was carried. Enzymatic activity of leukocyte elastase, functional activity of a1-proteinase inhibitor, level of autoantibodies to MBP (inflammatory markers), as well as the content of p53 and Bcl-2 proteins (markers of apoptosis) were determined in serum. The control group consisted of 35 somatically healthy people of the appropriate age and sex. Results. Identified the different features of the spectrum of the analyzed markers of inflammation and apoptosis in patients with positive and negative dynamics of neurological symptoms in the acute period of ischemic stroke assessed according to the ESS and NIHSS scales. The observed clinical and biological relationships reflect the features of the course of the early post-stroke period and can be considered as possible predictors of the development trajectory of acute brain ischemia. |
| 5. | Publisher | Organizing agency, location | Eco-Vector |
| 6. | Contributor | Sponsor(s) | |
| 7. | Date | (DD-MM-YYYY) | 15.12.2019 |
| 8. | Type | Status & genre | Peer-reviewed Article |
| 8. | Type | Type | Conference Report, Theses of Report |
| 9. | Format | File format | |
| 10. | Identifier | Uniform Resource Identifier | https://journals.eco-vector.com/MAJ/article/view/19361 |
| 11. | Source | Title; vol., no. (year) | Medical academic journal; Vol 19, No 1S (2019) |
| 12. | Language | English=en | ru |
| 13. | Relation | Supp. Files | |
| 14. | Coverage | Geo-spatial location, chronological period, research sample (gender, age, etc.) | |
| 15. | Rights | Copyright and permissions |
Copyright (c) 2019 Zozulya S.A., Otman I.N., Chukanova A.S., Klyushnik T.P. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. |