INTRARENAL BLOOD FLOW DYNAMICS IN PATIENTS WITH ARTERIAL HYPERTENSION ASSOCIATED WITH SUBCLINICAL HYPOTHYROIDISM AGAINST THE BACKGROUND OF ANTIHYPERTENSIVE THERAPY

Aim. To assess the dynamics of intrarenal blood flow in patients with arterial hypertension (AH) associated with subclinical hypothyroidism (HT) against the background of antihypertensive therapy. Materials and methods. Sixty eight patients divided into 2 following groups were examined: group 1 during 18 months took amlodipin + indapamide, group 2 – lisinopril + indapamide. Results. Eighteen months later, against the background of combined therapy including amlodipin + indapamide, renal arteries’ resistance indices increased (right RI 0,659±0,03 and 0,677±0,035; p =0,03); left RI 0,665±0,038 and 0,689±0,033); p =0,005) and renal venous blood flow became worse (right dV ven 20,33±5,72 and 23,73±3,66; p =0,003; left dV ven 21,52±5,90 and 25,23±3,71; p =0,003). Combined lisinopril + indapamide therapy significantly improved renal magistral venous blood flow (right dV 19,78±3,43 and 18,10±2,87; p =0,04; left dV22,07±5,12 and 19,53±4,36; p =0,04). Conclusion. Lisinopril combined with indapamide should be recommended as an antihypertensive therapy to patients with AH associated with SH.

Arterial hypertension, subclinical hypothyroidism, renal blood flow, antihypertensive therapy