CHANGES IN THE STRUCTURE OF THE PROSTATE GLAND OF REPRODUCTIVE-AGE RATS UNDER IMMUNOSUPPRESSION CONDITIONS

The aim of the study was to establish a change in the structure of the prostate gland of experimental animals of reproductive age under conditions of prolonged immunosuppression. The study was carried out on 60 white rats of reproductive age. The state of immunosuppression was modeled using cyclophosphamide at a dosage of 1.5 mg/kg body weight intramuscularly for 10 days. The linear dimensions and volume of the organ were determined. At the microscopic level, the height and width of the epithelial cells, their volume, as well as the larger and smaller diameters and the volume of the cell nuclei were measured. In response to long-term immunosuppressive effects, the organometric parameters of the prostate are decreased both at the early (7, 15 days) and late (30 days) observations due to the direct cytotoxic effect of cyclophosphamide on the glandular-stromal components of the organ. The decrease in the values ​​of linear-volume micromorphometric parameters at the same time of observation confirms the dynamics of the organometric parameters of the gland and indicates an intensive organ response at the micro- and submicroscopic level.