Anxious-depressive symptomatology and brain-derived neurotrophic factor level in patients with tension headache

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Abstract


Aim. To study the correlation between the blood serum brain-derived neurotrophic factor (BDNF) level and the manifestation of anxious-depressive symptomatology in patients with tension headache.

Materials and methods. The study involved 82 patients with tension headache. The method of immune-enzyme assay with test-system ELISA kit was used to measure the blood serum BDNF concentration.

Results. The BDNF level in patients with episodic infrequent and frequent tension headaches was comparable with the group of control. Among patients with chronic tension headache, decrease in BDNF level as compared to group 1, group 2 and the control was revealed. The BDNF level is changed, depending on the duration and intensiveness of tension headache.

Conclusions. Chronic tension headache causes exhaustion of not only mediator, but of neurotrophic systems of the brain as well. Blood serum BDNF concentration measured permits to assess activity of cerebral neuroplastic processes and to choose neurotrophic therapy for a more rapid triggering of serotoninergic system and arresting of anxious-depressive syndrome.


K. V. Tyan

Pacific State Medical University

Author for correspondence.
Email: tyan_ksusha@mail.ru

Russian Federation, Vladivostok

аспирант кафедры психиатрии и неврологии

P. P. Kalinsky

Pacific State Medical University

Email: tyan_ksusha@mail.ru

Russian Federation, Vladivostok

доктор медицинских наук, профессор кафедры психиатрии и неврологии

A. V. Rakitova

Pacific State Medical University

Email: tyan_ksusha@mail.ru

Russian Federation, Vladivostok

ассистент кафедры психиатрии и неврологии

  • Головная боль: руководство для врачей. Под ред. Г.Р. Табеева. М.: ГЭОТАР-Медиа 2014; 288.
  • Каракулова Ю.В. Серотониновая система периферической крови больных головной болью напряжения (клинико-биохимическое исследование): дис. … д-ра мед. наук 2006; 159.
  • Осипова В.В., Табеева Г.Р. Первичные головные боли: диагностика, клиника, терапия: практическое руководство. М.: Медицинское информационное агентство 2014; 143.
  • Стайнер Т.Дж. и соавт. Европейские принципы ведения пациентов с наиболее распространенными формами головной боли в общей практике: практическое руководство для врачей. Пер. с англ. Ю.Э. Азимовой, В.В. Осиповой; науч. ред. В.В. Осиповой, Т.Г. Вознесенской, Г.Р. Табеевой. - М.: ООО «ОГГИ. Рекламная продукция» 2010; 56.
  • Celada P., Siuciak J.A., Tran T.M., Altar C.A., Tepper J.M. Local infusion of brain-derived neurotrophic factor modifies the firing pattern of dorsal raphe serotonergic neurons. Brain Res 1996; 712: 293-298.
  • Deltheil T., Guiard B.P., Cerdan J. Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice. Neuropharmacology 2008; 55 (6): 1006-1014.
  • Jensen R., Symon D. Epidemiology of tension-type headaches. In: The Headaches. 3rd ed. Olsen J., Goadsby P.J., Ramadan N.M., Tfelt-Hansen P., Welch K.M.A. (eds.). Lippincott Williams & Wilkins 2006; 621-624.
  • Mamounas L.A., Altar C.A., Blue M.E., Kaplan D.R., Tessarollo L., Lyons W.E. BDNF promotes the regenerative sprouting, but not survival of injured serotonergic axons in the adult rat brain. J Neurosci 2000; 20: 771-782.
  • Mattson M.P., Maudsley S., Martin B. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 2004; 27 (10): 589-584.
  • Rumajogee P., Madeira A., Verge D., Hamon M., Miquel M.C. Upregulation of the neuronal serotoninergic phenotype in vitro: BDNF and cAMP share Trk B dependent mechanisms. J Neurochem 2002; 83: 1525-1528.

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