Chronic uterine inflammation: some pathogenetic aspects

Cover Page

Abstract


Currently, molecular-genetic studies attract attention of many scientists; there are contradictory and ambiguous data on some genes and their role in chronic inflammations of pelviс organs. Some immunogenetic aspects of pathogenesis of chronic endometritis are presented in this review; the role of mutual effect of gene dysregulation and immune system is indicated, the data on possible link between functional endometrium status and pathological polymorphism of some genes are cited.


E. G. Kobaidze

Author for correspondence.
eka7i@yahoo.com
Academician Ye.A. Vagner Perm State Medical University
Russian Federation, Perm

кандидат медицинских наук, доцент кафедры акушерства и гинекологии

  • Брюне Б., Сандау К., фон Кнетен А. Апоптотическая гибель клеток и оксид азота: механизмы активации и антагонистические сигнальные пути. Биохимия 1998; 63(7): 966-975.
  • Горбунова В.Н. Генетика человека с основами медицинской генетики: учеб. для студ. учреждений сред.-проф. учеб. заведений. М.: Академия 2012; 240.
  • Кетлинский С.А., Симбирцев А.С. Цитокины. СПб.: Фолиант 2008; 552.
  • Ковальчук Л.В., Хорева М.В., Варивода А.С. Врожденные компоненты иммунитета: Toll-подобные рецепторы в норме и патологии. ЖМЭИ 2005; 4: 96-104.
  • Кокряков В.Н. Очерки о врожденном иммунитете. СПб.: Наука 2006; 261.
  • Кондриков Н. И. Патология матки. М.: Практическая медицина 2008; 344.
  • Радзинский В.Е. Репродуктивная инфектология XXI века. Status Praesens 2013; 16 (5): 33-36.
  • Радзинский В.Е. Прегравидарная подготовка. Клинический протокол. М.: Редакция журнала Status Praesens, 2017; 27.
  • Руководство по амбулаторно-поликлинической помощи в акушерстве и гинекологи. Под ред. В.Н. Серова, Г.Т. Сухих, В.Н. Прилепской, В.Е. Радзинского. М.: ГЭОТАР-Медиа 2016;1136.
  • Серебренникова С.Н., Семинский И.Ж. Патофизиология воспалительного процесса. Иркутск: ИГМУ 2014; 82.
  • Симбирцев А.С. Цитокины: классификация и биологические функции. Цитокины и воспаление 2004; Т. 3 (2): 16-23.
  • Сухих Г.Т., Шуршалина А.В. Хронический эндометрит. М.: ГЭОТАР-Медия 2010; 64.
  • Черешнев В.А., Юшков Б.Г. Патофизиология. М.: ВЕЧЕ 2001; 702.
  • Черешнев В.А., Гусев Е.Ю. Иммунология воспаления: роль цитокинов. Медицинская иммунология. 2001; Т. 3(3): 361-368.
  • Abrahams V.M., Bole-Aldo P., Kim Y.M. Divergent trophoblast responses to bacterial products mediated by Toll-like receptors. J Immunol 2004; 173: 4286-4296.
  • Akbar A.N., Vukmanovic-Stejic M., Taams L.S., Macallan D.C. The dynamic co-evolution of memory and regulatory CD4+ T cells in the periphery. Nat Rev Immunol 2007; 7: 231-237.
  • Almawi W.Y., Saldanha F.L., Mahmood N.A., Al-Zaman I., Sater M.S., Mustafa F.E. Relationship between VEGFA polymorphisms and serum VEGF protein levels and recurrent spontaneous miscarriage. Hum Reprod 2013; 28(10): 2628-2635.
  • Aruoma O.I. Free radicals and antioxidant strategies in sports. J of Nutritional Biochem 1994; (5)8: 370-381.
  • Bagheri A., Kumar P., Kamath A., Rao P. Association of angiogenic cytokines (VEGF-A and VEGF-C) and clinical characteristic in women with unexplained recurrent miscarriage. Bratisl Lek Listy 2017; 118(5): 258-264.
  • Cicinelli E., DeZiegler, D., Nicoletti R., Colafiglio G., Saliani N.,Resta L. Chronic endometritis: correlation among hysteroscopic, histologic, and bacteriologic findings in a prospective trial with 2190 consecutive office hysteroscopies. Fertil Steril 2008; 89 (3): 677-684.
  • Dongyou Liu. Ed. By. Molecular detection of human bacterial pathogens. Taylor & Francis Group. Boca Raton London New York CRC Press 2011; 1278.
  • Folkman J. Angiogenesis. Annu Rev Med 2006; 57: 1-18.
  • Garrido-Gómez T., Ruiz-Alonso M., Blesa D., Diaz-Gimeno P., Vilella F., Simón C. Profiling the gene signature of endometrial receptivity: clinical results. Fertil Steril 2013; 99: 1078-1085.
  • Gargano J.W., Holzman C., Senagore P., Thorsen P., Skogstrand K., Hougaard D.M., Rahbar M.H., Chung H. Mid-pregnancy circulating cytokine levels, histologic chorioamnionitis and spontaneous preterm birth. J Reprod Immunol 2008; 79: 100-110.
  • Herbst-Kralovetz M.M., Quayle A.J., Ficarra M. Quantification and comparison of Toll-like receptor expression and responsiveness in primary and immortalized human female lower genital tract epithelia. Am J Reprod Immun 2008; 59(3): 212-224.
  • Ignarro L.J. Biosynthesis and methabolism of endothelium-derived nitric oxide. Pharmacol Toxicol 1990; 67: 1-7.
  • Kirschning C.J., Schumann R.R. TLR2: cellular sensor for microbial and endogenous molecular patterns. Cur. Topics in Microbiol & Immunol 2002; 270: 121-144.
  • Kushnir V. A. Systemic inflammation and autoimmunity in women with chronic endometritis. Am J Reprod Immunol 2016; 75 (6): 672-677.
  • Lee S.K., Kim J.Y., Hur S.E., Kim C.J., Na B.J., Lee M., Gilman-Sachs A., Kwak-Kim J. An imbalance in interleukin-17-producing T and regulatory T cells in women with idiopathic recurrent pregnancy loss. Hum Reprod 2011; 26(11): 2964-2971.
  • Mantovani A., Bussolino F., Intora M. Cytokine regulation endothelial cell function: from molecular level to bedside. Immunology Today 1997; 18(5): 231-239.
  • Matsumoto M., Kikkawa S., Kohase M., Miyake K., Seya T. Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling. BBRC 2002; 293(5): 1364-1369.
  • McFee R.M., Rozell T.G., Cupp A.S. The balance of proangiogenic and antiangiogenic VEGFA isoforms regulate follicle development. Cell Tissue Res 2012; 349 (3): 635-647.
  • Medzhitov R., Preston-Hurlburt P., Kopp E. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 1998; 2(2): 253-258.
  • Papanicolaou D.A, Wilder R.L., Manolagas S.C., Chrou-sos G.P. The pathophysiologic roles of interleukin-6 in human diseases. Annals of Internal Medicine 1998; 128 (2): 127-137.
  • Pioli P.A., Amiel E., Schaefer T.M., Connolly J.E., Wira C.R., Guyre P.M. Differential expression of Toll-like receptors 2 and 4 in tissues of the human female reproductive tract. Infect & Immun 2004; 72 (10): 5799-5806.
  • Ruiz-Alonso M., Blesa D., Simón C. The genomics of the human endometrium. Biochim. Biophys Acta 2012; 1822: 1931-1942.
  • Sakaguchi S. Naturally arising Foxp3-expressing CD25 + CD4 + regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005; 6: 345-352.
  • Sen G.C., Sarkar S.N. Transcriptional signaling by doublestranded RNA: role of TLR3. Cytokine and Growth Factor Reviews 2005; 16(1): 1-14.
  • Shibuya M. Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases. J Biochem 2013; 153(1): 13-19
  • Thompson C.B. Apoptosis in the patho-genesis of disease. Sci 1995; 267: 1456-1462.

Views

Abstract - 14

PDF (Russian) - 4


Copyright (c) 2017 Kobaidze E.G.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.