Metabolic aspects of acute stage ischemic stroke

Cover Page

Abstract


Aim. To study the influence of hyperglycemia on the course of ischemic stroke in its acute period.

Materials and methods. 116 patients with primary ischemic stroke, associated with arterial hypertension, and with no diabetes mellitus in anamnesis were examined. Fasting blood glucose, glycolyzed hemoglobin, immunoreactive insulin and C-peptide levels were determined.

Results. Raised levels of glycemia to 5.31 ± 0.68 mmol/l, C-peptide to 0.90 ± 0.31 nmol/l and decreased level of insulin to 9.38 ± 4.34 mcIU/ml were detected. C-peptide to insulin ratio values were reliably higher in patients with severe course of stroke (by 35.6 %, p < 0.05) and unfavorable outcome of disease (by 39.6 %, p < 0.05).

Conclusions. Development of ischemic stroke is accompanied by high blood C-peptide levels against the background of normo-and-hypoinsulinemia, hyperglycemia. Manifestation of disorders is connected with severity and clinical outcome of this disease.


G. I. Izhbuldina

City Clinical Hospital № 18

Author for correspondence.
Email: gulnara-ufa@list.ru

Russian Federation, Ufa

кандидат медицинских наук, заведующая неврологическим отделением для больных с ОНМК

L. B. Novikova

Bashkir State Medical University

Email: gulnara-ufa@list.ru

Russian Federation, Ufa

доктор медицинских наук, профессор, заведующая кафедрой неврологии и нейрохирургии ИДПО

D. A. Timerbayeva

City Clinical Hospital № 18

Email: gulnara-ufa@list.ru

Russian Federation, Ufa

кандидат медицинских наук, заведующая иммунологической лабораторией

E. V. Sharipova

City Clinical Hospital № 18

Email: gulnara-ufa@list.ru

Russian Federation, Ufa

заведующая клинико-диагностической лабораторией

R. V. Murzabayeva

City Clinical Hospital № 18

Email: gulnara-ufa@list.ru

Russian Federation, Ufa

врач-лаборант иммунологической лаборатории

  • Виленский Б.С. Инсульт – современное состояние проблемы. Неврологический журнал 2008; 2: 4–10.
  • Гусев Е.И., Скворцова В.И., Стаховская Л.В. Проблема инсульта в Российской Федерации: время активных совместных действий. Журнал неврологии и психиатрии им. Корсакова 2007; 8: 4–8.
  • Badiger Sh., Akkasaligar P.T., Narone U. Hyperglycemia and stroke. Int J Stroke Res 2013; 1: 1–6.
  • Clark M.E., Payton J.E., Pittiglio L.I. Acute ischemic stroke and hyperglycemia. Critical Care Nursing Quarterly 2014; 37: 182–187.
  • Lattanzi S., Bartolini M., Provinciali L., Silvestrini M. Glycosylated hemoglobin and functional outcome after acute ischemic stroke. J Stroke & Cerebrovasc Dis 2016; 25: 1786–1791.
  • Li Y., Meng L., Li Y., Sato Y. Associations of serum C-peptide level with body fat distribution and ever stroke in nondiabetic subjects. J Stroke Cerebrovasc Dis 2014; 23: 163–169.
  • Mavrakanas T., Frachebois C., Soualah A., Aloui F., Julier I., Bastide D. C-peptide and chronic complications in patients with type-2 diabetes and the metabolic syndrome. Presse Medicale 2009; 38: 1399–1403.
  • Mostafa M.A., Mohamed N.A. Effect of glycemic control on the severity and outcome of stroke in Saudi Arabia. Egypt J Neurol Psychiatry Neurosurg 2015; 52: 228–231.
  • Rundek T., Gardener H., Xu Q., Goldberg R.B., Wright C.B., Boden-Albala B., Disla N., Paik M.C., Elkind M.S., Sacco R.L. Insulin resistance and risk of ischemic stroke among nondiabetic individuals from the northern Manhattan study. Arch Neurol 2010; 67: 1195–1200.
  • Vasic D., Marx N., Sukhova G., Bach H., Durst R., Grüb M., Hausauer A., Hombach V., Rottbauer W., Walcher D. C-peptide promotes lesion development in a mouse model of arteriosclerosis. J Cell Mol Med 2012; 16: 927–935.
  • Urabe T., Watada H., Okuma Y., Tanaka R., Ueno Y., Miyamoto N., Tanaka Y., Hattori N., Kawamori R. Prevalence of abnormal glucose metabolism and insulin resistance among subtypes of ischemic stroke in Japanese patients. Stroke 2009; 40: 1289–1295.

Views

Abstract - 349

PDF (Russian) - 92

PlumX


Copyright (c) 2018 Izhbuldina G.I., Novikova L.B., Timerbayeva D.A., Sharipova E.V., Murzabayeva R.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.