Reviews on Clinical Pharmacology and Drug TherapyReviews on Clinical Pharmacology and Drug Therapy1683-41002542-1875Eco-Vector1037810.17816/RCF16313-18Research ArticleTablet as a pharmaceutical form of medicinal products intended for administration inside: advantages and disadvantagesUrakovAleksandr L.<p>Dr. Med. Sci., Professor, Head, Department of General and Clinical Pharmacology</p>urakoval@live.ruIzhevsk State Medical Academy15102018163131826102018Copyright © 2018, Urakov A.L.2018<p>The review of the literature shows that modern tablets turn drugs into artificial stones with excessively high physical-chemical activity, which can cause caries, stomatitis, gastritis and stomach ulcers. The ways to increase the safety of tablets and their intake is indicated.</p>tabletsfood clumpsaggression drugsphysical-chemical activitya local irritantтаблеткипищевые комкиагрессивность лекарствфизико-химическая активностьместное раздражающее действие[Аничков С.В. К 30-летию со дня смерти H.П. Кравкова // Фармакология и токсикология. - 1954. - Т. 17. - № 3. - С. 5-10. [Anichkov SV. К 30-letiyu so dnja smerti N.P. Kravkova. On the 30th anniversary of N.P. Kravkovʼs death. Pharm and toxicol. 1954;17(3):5-10. (In Russ.)]][Закусов В.В. Н.П. Кравков (к 100-летию со дня рождения) // Клиническая медицина. - 1965. - Т. 43(И). - С. 5-9. [Zakusov VV. N.P. Кravkov (k 100letiyu so dnja rozhdenia). N.P.Kravkov (to the 100th anniversary of the birth). Klin Med. 1965;43(I):5-9. (In Russ.)]][Игнатов Ю.Д., Сапронов Н.С., Шабанов П.Д. Фармакология в Санкт-Петербурге (исторические очерки). - СПб.: Элби-СПб, 2007. [Ignatov JuD, Sapronov NS, Shabanov PD. Pharmacology in Saint Petersburg (historical essay). Saint Petersburg: Elbi-SPb; 2007. (In Russ.)]][Кравков Н.П. Основы фармакологии. - 14-е изд. - Л.: ОГИЗ, 1933. [Kravkov NP. Basics of pharmacology. 14th ed. Leningrad: OGIZ; 1933. (In Russ.)]][Николаев М.П. Академик Н.П. Кравков и его школа // Фармакология и токсикология. - 1939. - Т. 2. - № 5. - С. 5-10. [Nikolaev МP. Akademik N.P.Kravkov I ego shkola. Pharm and Toxicol. 1939;2(5):5-10. (In Russ.)]][Харкевич Д.А. Фармакология. - 10-е изд. - М.: ГЭОТАР-Медиа, 2010. [Harkevich DА. Pharmacology. 10th ed. - Moscow: GEOTAR-Media; 2010. (In Russ.)]][Ураков А.Л. История формирования термофармакологии в России // Успехи современного естествознания. - 2014. - Т. 12. - С. 29-39. [Urakov AL. Istoria formirovania tervopharmacologii v Rossii. Advances in modern natural science. 2014;12:29-39. (In Russ.)]][Kasatkin A, Urakov A. Why the drug solutions may cause inflammation at the injection site. Proceedings of 6th World Congress on Medicinal Chemistry and Drug Design. (June 07-08, 2017 Milan, Italy). Journal of Medicinal Chemistry: Open Access. 2017;7(4):78.][Kasatkin AA, Urakov AL, Lukoyanov IA. Nonsteroidal anti-inflammatory drugs causing local inflammation of tissue at the site of injection. Journal of Pharmacology and Pharmacotherapeutics. 2016;7(1):26-28.][Urakov AL. The change of physical-chemical factors of the local interaction with the human body as the basis for the creation of materials with new properties. Epitőanyag - Journal of Silicate Based and Composite Materials. 2015;67(1):2-6. doi: 10.14382/epitoanyag-jsbcm.2015.1.][Urakov A, Urakova N, Reshetnikov A, et al. About what is happening in the stomach after swallowing human river pebbles, gravel, chalk, clay and tablets drugs. Epitőanyag - Journal of Silicate Based and Composite Materials. 2016;68(4):110-113. doi: 10.14382/epitoanyag-jsbcm.2016.19.][Urakov AL. Development of new materials and structures based on managed physical-chemical factors of local interaction. IOP Conf Ser: Materials Science and Engineering. 2016;123:012008.][Urakov A, Urakova N, Reshetnikov A, et al. The facts that the physical-chemical properties of modern tablets distinguish them from natural food lumps. IOP Conf Series: Materials Science and Engineering. 2017;175:012012.][Urakov AL, Urakova NA, Reshetnikov AP. Tablets manufactured by pressing powders from drugs, make the equivalent of artificial stones, that are not suitable for the digestive system of humans. Australasian Medical Journal. 2017;10(12):1062.][Urakova NA, Muravtseva OV, Urakov AL, et al. Floating tablet. Pat. RF No 2254121, 2005.]