Reviews on Clinical Pharmacology and Drug TherapyReviews on Clinical Pharmacology and Drug Therapy1683-41002542-1875Eco-Vector139110.17816/RCF13353-62Research ArticleProbable molecular genetic predictors for development of the locomotor system pathology in the extreme physical exertionKozlovaAnna SergeevnaMaster of Sci., Head of the Laboratory of Pharmacology and sports nutritionannete.kozlova@gmail.comPyatibratAlexandre OlegovichPhD (Pathophysiology), Head of the Research Department of the organization of scientific activitya5brat@yandex.ruBuznikGalina ViktorovnaPhD (Therapy), Doctorate Fellow, Department of Pharmacologya5brat@yandex.ruMelnovSergei BorisovichDr. Biol. Sci. (Genetics), Professor, Head. Dept. of Environmental and Molecular Medicinesbmelnov@gmail.comShabanovPeter DmitrievichDr. Med. Sci., Professor and Head, Department of Pharmacologypshabanov@mail.ruRepublican Scientific and Practical Center of SportsAll-Russian Centre of Extreme and Radiation Med., Emercom of RussiaS. M. Kirov Military Medical AcademyA. D. Sakharov International State Ecological University15092015133536227022016Copyright © 2015, Kozlova A.S., Pyatibrat A.O., Buznik G.V., Melnov S.B., Shabanov P.D.2015The article presents the basic results of the theoretical analysis of currently available data on modern and future using of molecular genetic markers to determine predisposition to musculoskeletal system diseases in athletes and subsequent regenerative capacity of the organism. The basic genetic markers associated with athletes resistance to injuries are described. It has been shown that one of the most important factors is genetic predisposition to osteoporosis.molecular geneticsgenetic predictorsdiseases of the musculoskeletal systemextreme conditionsosteoporosissports injuryмолекулярная генетикагенетические предикторызаболевания опорно-двигательного аппаратаэкстремальные нагрузкиостеопорозспортивная травма[Ахметов И. И. Генетическая диагностика в спортивной медицине. 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