Reviews on Clinical Pharmacology and Drug TherapyReviews on Clinical Pharmacology and Drug TherapyОбзоры по клинической фармакологии и лекарственной терапии1683-41002542-1875Eco-Vector62548210.17816/RCF625482ReviewsНаучные обзорыResearch ArticleCyclotides. Prospects for using violet oxytocin-like substances to create a new generation of pharmacological agentsЦиклотиды. Перспективы использования окситоциноподобных субстанций фиалки для создания нового поколения фармакологических средствhttps://orcid.org/0000-0001-9720-43812978-4545ProshinSergei N.ПрошинСергей Николаевич
Russian Federation

Dr. Sci. (Medicine)

д-р мед. наук

psnjsn@rambler.ruhttps://orcid.org/0000-0002-3759-86113452-7882GrishinVladimir V.ГришинВладимир Владимирович
Russian Federation
w.grischin@yandex.ruDedyanAlina AshotovnaДедянАлина Ашотовна
Russian Federation
cute.alina.dedyan@yandex.ruHerzen Russian State Pedagogical UniversityРоссийский государственный педагогический университет им. А.И. ГерценаLesgaft National State University of Physical Education, Sports and HealthНациональный государственный университет физической культуры, спорта и здоровья им. П.Ф. ЛесгафтаAcademician I.P. Pavlov First St. Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. ПавловаSaint Petersburg State Pediatric Medical UniversityСанкт-Петербургский государственный педиатрический медицинский университет2108202413112024223223-3342372550801202424042024Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttps://journals.eco-vector.com/RCF/article/view/625482

This review article focuses on the use of violets and their derivatives as medicinal agents. Special attention is given to the historical aspects of using the healing properties of violets, as well as the analysis of substances derived from these plants for pharmaceutical production. The article specifically discusses oxytocin-like substances found in violets, particularly cyclotides. Cyclotides are globular microproteins with a unique head-to-tail cyclized backbone stabilized by three disulfide bonds forming a cystine knot. The chemical characteristics of cyclotides make them suitable for use as recombinant scaffolds in the design and development of ligands for G protein-coupled receptors, which are part of the modern generation of drugs. The development of ligands for bradykinin and κ-opioid receptors, which are in demand in modern pharmacology, is described in detail.

Обзорная статья посвящена применению фиалки и продуктов из нее в качестве лекарственного средства. Основное внимание уделено историческим аспектам использования целительных свойств фиалки, а также анализу субстанций, получаемых из нее для фармацевтического производства. Специально рассматриваются окситоциноподобные субстанции фиалок, в частности циклотиды. Циклотиды являются глобулярными микропротеинами с уникальнойциклизованной основой «голова-к-хвосту», стабилизированной тремя дисульфидными связями, формирующими цистиновый узел. Химические особенности циклотид позволяют их использовать в качестве рекомбинантных каркасов для проектирования и разработки лигандов рецепторов, связанных с G-белками, относящихся к современному поколению лекарственных препаратов. Более подробно описано создание лигандов к брадикининовым и κ-опиоидным рецепторам, востребованным современной фармакологией.

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