Reviews on Clinical Pharmacology and Drug TherapyReviews on Clinical Pharmacology and Drug TherapyОбзоры по клинической фармакологии и лекарственной терапии1683-41002542-1875Eco-Vector62904710.17816/RCF629047ReviewsНаучные обзорыReview ArticleAbsorption, distribution, metabolism and excretion of carbon nanostructuresАбсорбция, распределение, метаболизм и экскреция наноструктур углеродаhttps://orcid.org/0000-0002-0999-82125568-8939LitasovaElena V.ЛитасоваЕлена Викторовна
Russian Federation

Cand. Sci. (Biology)

канд. биол. наук

llitasova@mail.ruhttps://orcid.org/0000-0002-1012-75615559-8089IljinViktor V.ИльинВиктор Владимирович
Russian Federation

Cand. Sci. (Chemistry)

канд. хим. наук

victor.iljin@mail.ruhttps://orcid.org/0000-0001-8679-13652927-6178PiotrovskiyLevon B.ПиотровскийЛевон Борисович
Russian Federation

Dr. Sci. (Biology), Professor

д-р биол. наук, профессор

levon-piotrovsky@yandex.ruInstitute of Experimental MedicineИнститут экспериментальной медицины1908202413112024223223-3342572761403202416082024Copyright ©; 2024, Eco-VectorCopyright ©; 2024, Эко-Вектор2024Eco-VectorЭко-Векторhttps://journals.eco-vector.com/RCF/article/view/629047

The interaction of any substance with the body is determined by several parameters, namely: its adsorption, distribution, metabolism, and excretion (ADME properties). Naturally, this also fully applies to such a class of compounds as carbon nanostructures. They are mostly composed of sp2-hybridized carbon atoms (except for nanodiamonds, which consist of sp3-hybridized atoms). However, they differ significantly in their properties. This review focuses on these differences. It covers fullerenes, nano-onions, carbon nanotubes, carbon nanohorns, graphene and its derivatives, as well as nanodiamonds.

Взаимодействие любого вещества с организмом определяется несколькими параметрами, а именно: его проникновением, распределением, трансформацией и выведением, другими словами свойствами ADME (absorption, distribution, metabolism and excretion). Естественно, это в полной мере относится и к такому классу соединений, как углеродные наноструктуры. В основном они образованы sp2-гибридизированными атомами углерода (за исключением наноалмазов, образованных sp3-гибридизированными атомами). Однако по свойствам они заметно отличаются друг от друга. Рассмотрению этих различий посвящен данный обзор, в котором рассмотрены фуллерены, наноонионы, углеродные нанотрубки, углеродные нанохорны, графен и его производные, а также наноалмазы.

carbon nanostructuresfullerenenanoionsnanotubesnanohornsgraphenesnanodiamondsADME propertiesнаноструктуры углеродафуллереннаноонионынанотрубкинанохорныграфенынаноалмазысвойства ADMEThe work was carried out within the framework of the state assignment of the Ministry of Education and Science of Russia FGWG-2022-0004 for 2022–2025 “Search for molecular targets for pharmacological action in addictive and neuroendocrine disorders and creation of new pharmacologically active substances acting on CNS receptors”.Работа выполнена в рамках государственного задания Минобрнауки России FGWG-2022-0004 на 2022–2025 гг. «Поиск молекулярных мишеней для фармакологического воздействия при аддиктивных и нейроэндокринных нарушениях и создание новых фармакологически активных веществ, действующих на рецепторы ЦНС».Schinazi RF, Sijbesma R, Srdanov G, et al. Synthesis and virucidal activity of a water-soluble, configurationally stable, derivatized C60 fullerene. 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