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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Reviews on Clinical Pharmacology and Drug Therapy</journal-id><journal-title-group><journal-title xml:lang="en">Reviews on Clinical Pharmacology and Drug Therapy</journal-title><trans-title-group xml:lang="ru"><trans-title>Обзоры по клинической фармакологии и лекарственной терапии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1683-4100</issn><issn publication-format="electronic">2542-1875</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">679530</article-id><article-id pub-id-type="doi">10.17816/RCF679530</article-id><article-id pub-id-type="edn">OJQURT</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Reviews</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Научные обзоры</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Development of oxygen-producing antihypoxants, oxygen fuzes and oxygen generators in Russia</article-title><trans-title-group xml:lang="ru"><trans-title>Разработка кислород-продуцирующих антигипоксантов, кислородных взрывателей и генераторов кислорода в России</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4233-9550</contrib-id><contrib-id contrib-id-type="spin">4858-1896</contrib-id><name-alternatives><name xml:lang="en"><surname>Urakova</surname><given-names>Natalya A.</given-names></name><name xml:lang="ru"><surname>Уракова</surname><given-names>Наталья Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>urakovanatal@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-5188-8900</contrib-id><contrib-id contrib-id-type="spin">2970-2672</contrib-id><name-alternatives><name xml:lang="en"><surname>Ergashev</surname><given-names>Oleg N.</given-names></name><name xml:lang="ru"><surname>Эргашев</surname><given-names>Олег Николаевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr.Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>ergashew@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9829-9463</contrib-id><contrib-id contrib-id-type="spin">1613-9660</contrib-id><name-alternatives><name xml:lang="en"><surname>Urakov</surname><given-names>Aleksandr L.</given-names></name><name xml:lang="ru"><surname>Ураков</surname><given-names>Александр Ливиевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р. мед. наук, профессор</p></bio><email>urakoval@live.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4286-3993</contrib-id><contrib-id contrib-id-type="spin">7315-5961</contrib-id><name-alternatives><name xml:lang="en"><surname>Mokrenko</surname><given-names>Eugenii V.</given-names></name><name xml:lang="ru"><surname>Мокренко</surname><given-names>Евгений Владимирович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>д-р мед. наук</p></bio><email>mokrenko@newstom.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-0923-4555</contrib-id><contrib-id contrib-id-type="spin">3096-3159</contrib-id><name-alternatives><name xml:lang="en"><surname>Makarova</surname><given-names>Polina A.</given-names></name><name xml:lang="ru"><surname>Макарова</surname><given-names>Полина Анатольевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>polya.makarova.2000@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Experimental Medicine</institution></aff><aff><institution xml:lang="ru">Институт экспериментальной медицины</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Izhevsk State Medical Academy</institution></aff><aff><institution xml:lang="ru">Ижевская государственная медицинская академия</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Irkutsk State Medical University</institution></aff><aff><institution xml:lang="ru">Иркутский государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-10-20" publication-format="electronic"><day>20</day><month>10</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-04-10" publication-format="electronic"><day>10</day><month>04</month><year>2026</year></pub-date><volume>24</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>41</fpage><lpage>54</lpage><history><date date-type="received" iso-8601-date="2025-05-11"><day>11</day><month>05</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-10-20"><day>20</day><month>10</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/RCF/article/view/679530">https://journals.eco-vector.com/RCF/article/view/679530</self-uri><abstract xml:lang="en"><p>It is reported that pharmacologists in St. Petersburg and Izhevsk have discovered several new groups of medicines. Oxygen-producing antihypoxants, oxygen fuzes, and oxygen generator, invented on the initiative of Alexander Urakov, are listed in chronological order. It is shown that new drugs were created by physico-chemical repurposing of hydrogen peroxide from acidic antiseptics to warm alkaline hydrogen peroxide solution. The list of invented medicines, the composition of the ingredients of the created medicines and the mechanism of their action when applied topically are given. It is reported that the pharmacological target of oxygen-producing antihypoxants and oxygen fuze is the enzyme catalase, which is present in all tissues of the human body. It is indicated that catalase breaks down hydrogen peroxide into water and molecular oxygen at a tremendous rate. A chemical calculation is given showing that at a temperature of +42°C, 1 liter of oxygen gas is formed from 100 ml of a 3% solution of hydrogen peroxide under the action of catalase. It is shown that the involvement of Professor Peter Shabanov in the study accelerated and expanded the development of oxygen-producing antihypoxants and led to the discovery of intrapulmonary, endobronchial and endotracheal injections, as well as a new group of drugs—oxygen generators. This information proves that Russia became the first country in the world to invent warm alkaline hydrogen peroxide solutions for inhalation, intrapulmonary, endotracheal and endobronchial injections for the purpose of emergency oxygenation of blood through the lungs in respiratory obstruction and asphyxia. In addition, Russia is also the birthplace of “oxygen fuzes” and the first individual portable oxygen generator for first aid in case of suffocation caused by lack of oxygen in the inhaled air.</p></abstract><trans-abstract xml:lang="ru"><p>Россия стала первой страной в мире, где были изобретены тёплые щелочные растворы перекиси водорода для ингаляционных, внутрилёгочных, эндотрахеальных и эндобронхиальных инъекций с целью неотложной оксигенации крови через лёгкие при респираторной обструкции и асфиксии. Кроме этого, Россия является родиной кислородных взрывателей и первого индивидуального переносного генератора кислорода для оказания первой доврачебной помощи при удушье, вызванном недостатком кислорода во вдыхаемом воздухе. Фармакологи Санкт-Петербурга и Ижевска открыли несколько новых групп лекарственных препаратов. В статье в хронологической последовательности приведены изобретённые по инициативе Александра Уракова кислород-продуцирующие антигипоксанты, кислородные взрыватели и кислородные генераторы. Путём физико-химического перепрофилирования перекиси водорода из кислых антисептиков в тёплые щелочные растворы перекиси водорода были созданы новые лекарственные препараты. Приводятся список изобрётенных лекарственных средств, состав ингредиентов созданных лекарств и механизм их действия при местном применении. Сообщается, что фармакологической мишенью кислород-продуцирующих антигипоксантов и кислородных взрывателей является фермент каталаза, присутствующая во всех тканях организма человека. Каталаза с огромной скоростью расщепляет перекись водорода на воду и молекулярный кислород. Приведён химический расчёт, показывающий, что при температуре 42°С под действием каталазы из 100 мл 3% раствора перекиси водорода образуется 1 л газообразного кислорода. Подключение к исследованию профессора Петра Шабанова ускорило и расширило разработку кислород-продуцирующих антигипоксантов и привело к открытию внутрилёгочных, эндобронхиальных и эндотрахеальных инъекций, а также новой группы лекарств-генераторов кислорода.</p></trans-abstract><kwd-group xml:lang="en"><kwd>hypoxemia</kwd><kwd>hypoxia</kwd><kwd>brain</kwd><kwd>resistance</kwd><kwd>survival</kwd><kwd>antihypoxants</kwd><kwd>oxygen</kwd><kwd>generators</kwd><kwd>fuzes</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>гипоксемия</kwd><kwd>гипоксия</kwd><kwd>головной мозг</kwd><kwd>резистентность</kwd><kwd>выживаемость</kwd><kwd>антигипоксанты</kwd><kwd>кислород</kwd><kwd>генераторы</kwd><kwd>взрыватели</kwd></kwd-group><funding-group><funding-statement xml:lang="en">The work was carried out within the framework of the state assignment of the Institute of Experimental Medicine FGWG-2025-0020</funding-statement><funding-statement xml:lang="ru">Работа выполнена в рамках государственного задания по теме НИР ФГБНУ «Институт экспериментальной медицины» FGWG-2025-0020</funding-statement></funding-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Shabanov PD. Creator of the concept of antihypoxants and actoprotectors: On the occasion of the 100th anniversary of Professor V.M. Vinogradov. Psychopharmacology and biological narcology. 2024;15(1):79–90. doi: 10.17816/phbn625959 EDN: BJMCWT</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Shabanov PD. Founder of the concept of antihypoxants (in memory of Prof. Vasily Mikhailovich Vinogradov). Bulletin of the Russian Military Medical Academy. 2004;(1):115–119. EDN: ANEUVU (In Russ.)</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Shabanov PD. Department of pharmacology of the Imperial Medical and Surgical (Military Medical) Academy: history of the second century of existence (1899–2000). Psychopharmacology and biological narcology. 2023;14(2):113–138. doi: 10.17816/phbn501756 EDN: GJTYPM</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Shabanov PD. Department of pharmacology of the military medical academy in the 21st century: New achievements based on historical traditions (2000–2023). Psychopharmacology and biological narcology. 2023;14(4):263–284. doi: 10.17816/phbn623094 EDN: BEXXZK</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Okovityi SV, Ivanova OV. Clinical evaluation of the use of bemitil in the complex treatment of patients with chronic hepatitis. Psychopharmacology and biological narcology. 2002;2(1–2):238–245. EDN: SMMHHN (In Russ.)</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Voronina TA. Antioxidant mexidol. Main neuropsychotropic effects and mechanism of action. Psychopharmacology and Biological Narcology. 2001;1(1):2–12. (In Russ.)</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Shabanov PD. The origins and background of the creation of the nootropics concept. Neurochemical Journal. 2023;40(2):101–107. doi: 10.31857/S1027813323020127 EDN: UCVTWX</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Shabanov PD. Talented biochemical pharmacologist Professor Irina V. Zarubina. Psychopharmacology and biological narcology. 2024;15(2):173–174. doi: 10.17816/phbn629138 EDN: CAKSUY</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Shabanov PD, Zarubina IV. Hypoxia and antihypoxants, focus on brain injury. Reviews on Clinical Pharmacology and Drug Therapy. 2019;17(1):7–16. doi: 10.17816/RCF1717-16 EDN: NNOOGA</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Patent SU 1263248/ 15.10.1986. Urakov AL, Baranov AG, Pinegin AV. A way to stop bleeding. (In Russ.)</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Patent SU 1783985/ 23.12.1992.Urakov AL, Kravchuk AP, Lekontseva OI. Method of treatment of laryngospasm. (In Russ.)</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Patent RU 2187287/ 20.08.2002. Strelkov NS, Urakov AL, Korovyakov AP, et al. A method of treating long-term non-healing wounds. (In Russ.)</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Patent RU 2190215/ 27.09.2002. Urakova NA, Urakov AL, Korovyakov AP, et al. The method of infusion of medicines according to Urakov AL. (In Russ.)</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Patent RU 2192789/ 20.11.2002. Strelkov NS, Urakov AL, Urakova NA, Korovyakov AP. The method of spinal anesthesia according to Urakova NA. (In Russ.)</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Patent RU 2201251/ 27.03.2003. Strelkov NS, Urakov AL, Korovyakov AP, et al. The method of infusion of medicines to patients with diabetes mellitus. (In Russ.)</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Urakova NA, Urakov AL, Chereshnev VA, et al. Hypergasification, hyperbaricity, hyperosmolarity, hyperthermicity, hyperalcalinity and high surface activity of the solution as factors for increasing its washing activity. Chemical Physics and Mesoscopy. 2007;9(3):256–262. (In Russ.) EDN: PJLSLP</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Patent RU 2336833/ 27.10.2008. Chereshnev VA, Strelkov NS, Urakov AL, et al. Method for peritoneal dialysis using gasified solution. (In Russ.)</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Patent RU 2331441/ 20.08.2008. Chereshnev VA, Strelkov NS, Urakov AL, et al. Hyper-gassed and hyper-osmotic antiseptic mixture. (In Russ.)</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Urakova NA, Urakov AL, Tolstolutskij AJ, Strelkov NS. Heating and alcfline solutions of antiseptic means raises efficiency of sanitation of purulent cavities. Medical Bulletin of Bashkortostan. 2008;3(2):74–76. EDN: KHQTZR</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Urakova NA, Urakov AL, Mikhaylova NA, et al. A 3% hydrogen peroxide solution heated to 42°C and saturated with sodium bicarbonate is a leader in thinning thick and sticky pus. Medical Care. 2009;(1):46–48. EDN: KFATLT</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Urakov AL, Urakova NA, Yushkov BG, et al. Gipertermia, gipergazation and giperalkalization of solutions as factors its piolitics activity. Bulletin of the Ural Medical Academic Science. 2011;(1):84–87. EDN: OPFCXZ</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Urakov AL, Urakova NA, Chernova L. Possibility of dissolution and removal of thick pus due to the physical-chemical characteristics of the medicines. Journal of Materials Science and Engineering B. 2013;3(11):714–720. doi: 10.17265/2161-6221/2013.11.005</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Urakov AL. The change of physical-chemical factors of the local interaction with the human body as the basis for the creation of materials with new properties. Epitőanyag – Journal of Silicate Based and Composite Materials. 2015;67(1):2–6. doi: 10.14382/epitoanyag-jsbcm.2015.1. 263</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Urakov AL. Development of new materials and structures based on managed physical-chemical factors of local interaction. IOP Conf Ser: Mater Sci Eng. 2016;123:012008. doi: 10.1088/1757-899X/123/1/012008</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Urakov A, Urakova N, Reshetnikov A, et al. The facts that the physical-chemical properties of modern tablets distinguish them from natural food lumps. IOP Conf Ser: Mater Sci Eng. 2017;175:012012. doi: 10.1088/1757-899X/175/1/012012</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Urakov AL. Creation of “necessary” mixtures of baking soda, hydrogen peroxide and warm water as a strategy for modernization bleaching cleaners of ceramic. Epitőanyag – Journal of Silicate Based and Composite Materials. 2020;72(1):30–35. doi: 10.14382/epitoanyag-jsbcm.2020.6</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Urakov A, Urakova N. Rheology and physical-chemical characteristics of the solutions of the medicines. Journal of Physics: Conference Series. 2015;602(1):012043. doi: 10.1088/1742-6596/602/1/01204 EDN: UFSOVB</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Patent RU2538662/ 10.01.2015. Urakov AL, Urakova NA, Reshetnikov AP, et al. Soikher’s hyperoxygenated agent for venous oxygen saturation. (In Russ.)</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Patent RU2563151/ 20.09.2015. Urakov AL, Urakova NA, Agarval RK, et al. Method of maintenance of live fish during transportation and storage. (In Russ.)</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Urakov AL, Shabanov PD. Acute respiratory syndrome-2 (SARS-CoV-2): A solution of hydrogen peroxide and sodium bicarbonate as an expectorant for recanalization of the respiratory tract and blood oxygenation in respiratory obstruction (review). Reviews on Clinical Pharmacology and Drug Therapy. 2021;19(4):383–393. doi: 10.17816/RCF194383-393 EDN: CVCWXY</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Urakov A, Urakova N, Reshetnikov A, et al. Catalase: A potential pharmacologic target for hydrogen peroxide in the treatment of COVID-19. Curr Top Med Chem. 2024;24(25):2191–2210. doi: 10.2174/0115680266322046240819053909</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Fisher E, Urakov A, Svetova M, et al. COVID-19: intrapulmonary alkaline hydrogen peroxide can immediately increase blood oxygenation. Med Cas. 2021;55(4):135–138. doi: 10.5937/mskg55-3524</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Urakov АL, Urakova NA. COVID-19: intrapulmonary injection of hydrogen peroxide solution eliminates hypoxia and normalizes respiratory biomechanics. Russian Journal of Biomechanics. 2021;25(4):350–356. doi: 10.15593/RJBiomech/2021.4.06</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Shabanov PD, Fisher EL, Urakov AL. Hydrogen peroxide formulations and methods of their use for blood oxygen saturation. J Med Pharm Allied Sci. 2022;11(6):5489–5493. doi: 10.55522/jmpas.V11I6.4604</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Fisher EL, Urakov AL, Shabanov PD. Increased survival of aquarium fish under acute hypoxia induced by prior intragastric administration of hydrogen peroxide. Reviews on Clinical Pharmacology and Drug Therapy. 2024;22(3):301–308. doi: 10.17816/RCF633024 EDN: KAZVUK</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Shabanov PD, Urakov A, Urakova NA. Assessment of fetal resistance to hypoxia using the Stange test as an adjunct to Apgar scale assessment of neonatal health status. Medical Academic Journal. 2023;23(3):89–102. doi: 10.17816/MAJ568979 EDN: OFZNNV</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Urakov AL, Urakova NA, Shabanov PD. Hypoxic irreversible brain cells damage, associated risk factors and antihypoxants. Reviews on Clinical Pharmacology and Drug Therapy. 2024;22(3):277–288. doi: 10.17816/RCF629408 EDN: FWRGAK</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Urakova NA, Urakov AL, Shabanov PD. Monitoring of fetal biomechanics during apnea in a pregnant woman as a method of prenatal screening. Russian Journal of Biomehanics. 2025;29(1):112–122. doi: 10.15593/RJBiomech/2025.1.08</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Urakova N, Urakov A, Olaiya V, et al. Fetal movements during maternal apnea in the third trimester of pregnancy: An indicator of resistance to intrauterine hypoxia. Curr Women’s Health Rev. 2025;22(1):e15734048344660. doi: 10.2174/0115734048344660250220054204</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Srichawla BS. Future of neurocritical care: Integrating neurophysics, multimodal monitoring, and machine learning. World J Crit Care Med. 2024;13(2):91397. doi: 10.5492/wjccm.v13.i2.91397</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Metz C, Taeger K. Head-brain injury and cerebral hypoxia. Diagnosis–monitoring–therapy. Anaesthesist. 2000;49(4):332–339. (In German) doi: 10.1007/s001010050838</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Al-Beltagi M, Saeed NK, Bediwy AS, Elbeltagi R. Pulse oximetry in pediatric care: Balancing advantages and limitations. World J Clin Pediatr. 2024;13(3):96950. doi: 10.5409/wjcp.v13.i3.96950</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Teo J. Early detection of silent hypoxia in COVID-19 pneumonia using smartphone pulse oximetry. J Med Syst. 2020;44(8):134. doi: 10.1007/s10916-020-01587-6</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Plummer NR, Fogarty A, Shaw D, et al. Silent hypoxia is not an identifiable characteristic in patients with COVID-19 infection. Respir Med. 2022;197:106858. doi: 10.1016/j.rmed.2022.106858</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Ishida Y, Okada T, Kobayashi T, Uchino H. ORi™: a new indicator of oxygenation. J Anesth. 2021;35(5):734–740. doi: 10.1007/s00540-021-02938-4</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Urakov A, Muhutdinov N, Yagudin I, et al. Brain hypoxia caused by respiratory obstruction wich should not be forgotten in COVID-19 disease. Turk J Med Sci. 2022;52(5):1504–1505. doi: 10.55730/1300-0144.5489</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Torres C, García J, Meslé F, et al. Identifying age- and sex-specific COVID-19 mortality trends over time in six countries. Int J Infect Dis. 2023;128:32–40. doi: 10.1016/j.ijid.2022.12.004</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Alam M, Razzak A, Gilani MHS, et al. Comparison of clinical characteristics, hospital treatment and outcomes in all four waves of Covid-19 patients at RTEH Muzaffargarh, Pakistan. Pak J Med Sci. 2024;40(2ICON):S4–S9. doi: 10.12669/pjms.40.2(ICON).8947</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Urakov AL, Ammer K, Urakova NA, et al. Infrared thermography can discriminate the cause of skin discolourations. Therm Int. 2015;25(4):209–215. doi: 10.21611/qirt.2016.140</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Gurevich K, Urakov A, Fisher E, Shubina Z. Alkaline hydrogen peroxide solution is an expectorant, pyolytic, mucolytic, hemolytic, and bleaching drug for treating purulent diseases, hematomas and bruising. J Pharm Res Int. 2022;34(30B):13–20. doi: 10.9734/jpri/2022/v34i30B36073</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Urakov AL, Urakova NA, Reshetnikov AP, et al. Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds. Reviews on Clinical Pharmacology and Drug Therapy. 2023;21(4):287–297. doi: 10.17816/RCF606648 EDN: XWUGVK</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Urakov AL, Urakova NA, Yagudin II, et al. COVID-19: Artificial sputum, respiratory obstruction method and screening of pyolitic and antihypoxic drugs. BioImpacts. 2022;12(4):393–394. doi: 10.34172/bi.2022.23877</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Urakov A, Urakova N, Shabanov P, et al. Suffocation in asthma and COVID-19: Supplementation of inhaled corticosteroids with alkaline hydrogen peroxide as an alternative to ECMO. Preprints. 2023:2023070627. doi: 10.20944/preprints202307.0627.v1</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Osipov AN, Urakova NA, Urakov AL, Shabanov PD. Warm alkaline hydrogen peroxide solution as an oxygen-releasing antihypoxic drug: potential benefits and applications. Med Gas Res. 2025;15(1):134–135. doi: 10.4103/mgr.MEDGASRES-D-24-00058</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Urakova NA, Urakov AL. Hydrogen peroxide: Potential for repurposing into an oxygen-producing antihypoxant by generating oxygen gas. Biointerface Res Appl Chem. 2025;15(1). doi: 10.33263/BRIAC151.003</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Urakova NA, Urakov AL, Shabanob PD. Intrapulmonary and intrabronchial oxygen-producing antihypoxants eliminate asphyxia and hypoxemia. Med Gas Res. 2025;15(4):550–551. doi: 10.4103/mgr.MEDGASRES-D-25-00027</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Urakov AL, Rudrapal M, Urakova NA, et al. Medical “gas fuse”: quickly and gently eliminates cerumen. Med Gas Res. 2025;15(4):552–553. doi: 10.4103/mgr.MEDGASRES-D-25-00012</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Urakov AL. Thermal pharmacology: history and definition. Reviews on Clinical Pharmacology and Drug Therapy. 2021;19(1):87–92. doi: 10.17816/RCF19187-96 EDN: YIGBEQ</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Urakov AL, Shabanov PD. Physical-chemical repurposing of drugs. History of its formation in Russia. Reviews on Clinical Pharmacology and Drug Therapy. 2023;21(3):231–242. doi: 10.17816/RCF567782 EDN: IJCHYZ</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Urakov AL. COVID-19: Immediate lung reoxygenation with hydrogen peroxide: Reality or fantasy. Adv Biores. 2021;12(5B):359–363. doi: 10.15515/abr.0976-4585.12.5B.359363</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Urakov A, Urakova N, Fisher E, et al. Antiseptic pyolytics and warming wet compresses improve the prospect of healing chronic wounds. Explor Med. 2023;4:747–754. doi: 10.37349/emed.2023.00175</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Fisher EL, Urakov AL, Samorodov AV, et al. Alkaline hydrogen peroxide solutions: expectorant, pyolytic, mucolytic, haemolytic, oxygen-releasing, and decolorizing effects. Reviews on Clinical Pharmacology and Drug Therapy. 2023;21(2):135–150. doi: 10.17816/RCF492316 EDN: UDPAZJ</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Urakov A, Urakova N, Nikolenko V, et al. Current and emerging methods for treatment of hemoglobin related cutaneous discoloration: A literature review. Heliyon. 2021;7(1):e05954. doi: 10.1016/j.heliyon.2021.e05954</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Urakov A, Urakova N, Reshetnikov A. Oxygen alkaline dental’s cleaners from tooth plaque, food debris, stains of blood, and pus: A narrative review of the history of inventions. J Int Soc Prev Commun Dent. 2019;9(5):427–433. doi: 10.4103/jispcd.JISPCD_296_19</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Urakov A, Urakova N, Reshetnikov A, Kopylov M, Chernova L. Solvents of pus-medicines with physical-chemical aggressive action. Journal of Physics: Conf. Series. 2017;790: 012033. doi: 10.1088/1742-6596/790/1/01203. EDN: XVTWSV</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Urakova NA, Urakov AL. New generation antihypoxants: Alkaline hydrogen peroxide solutions as generators of medical gas oxygen. Psychopharmacology and biological narcology. 2025;16(1):36–42. doi: 10.17816/phbn642337 EDN: QZSRNS</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Urakova N, Urakov A, Shabanov P. Pharmacological activities of warm alkaline hydrogen peroxide solution and therapeutic potential in medicine: physical-chemical reprofiling as a promising lead for drug discovery. Anti-Infective Agents. 2025;23(4):e22113525351536. doi: 10.2174/0122113525351536241122063840</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Patent RU2807851C1/ 21.11.2023. Urakov AL, Urakova NA, Shabanov PD, et al. Warm alkaline solution of hydrogen peroxide for intrapulmonary injection. (In Russ.)</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Patent RU2831821C1/ 16.12.2024. Urakov AL, Urakova NA, Fisher EL. Oxygenated warm alkaline solution of hydrogen peroxide for intrapulmonary injection. (In Russ.)</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Patent RU2833321/ 17.01.2025. Urakov AL, Shabanov PD. Method of endobronchial injection of drug for emergency elimination of asphyxia. (In Russ.)</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Urakov A.L. Pus solvents as new drugs with unique physical and chemical property. Reviews on Clinical Pharmacology and Drug Therapy. 2019;17(4):89–95. doi: 10.17816/RCF17489-95 EDN: TNKCYX</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Schwartz SR, Magit AE, Rosenfeld RM, et al. Clinical practice guideline (update): earwax (cerumen impaction). Otolaryngol Head Neck Surg. 2017;157(3):539. doi: 10.1177/0194599817725542</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Ahluwalia J, Drury E, Haupert M. Removal of cyanoacrylate glue from the external auditory canal with hydrogen peroxide and acetic acid: a case report. Cureus. 2024;16(3):e57213. doi: 10.7759/cureus.57213</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Malaty J, Tudeen M, Williams MP, Orlando FA. Otology: cerumen impaction and aural foreign bodies. FP Essent. 2024;542:29–37.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Urakov A, Urakova N, Reshetnikov A, et al. Solvents of pus medicines with physical-chemical aggressive action. J Phys Conf Ser. 2017;790:012033. doi: 10.1088/1742-6596/790/1/012033</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Barten DG, Klokman VW, Cleef S, et al. When disasters strike the emergency department: a case series and narrative review. Int J Emerg Med. 2021;14(1):49. doi: 10.1186/s12245-021-00372-7</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>Mohanty CR, Biswas A, Radhakrishnan RV, et al. Triple train collision at Bahanaga Bazar: Disaster response and management: An observational study. Int J Crit Illn Inj Sci. 2024;14(4):208–214. doi: 10.4103/ijciis.ijciis_52_24</mixed-citation></ref></ref-list></back></article>
