Reviews on Clinical Pharmacology and Drug TherapyReviews on Clinical Pharmacology and Drug TherapyОбзоры по клинической фармакологии и лекарственной терапии1683-41002542-1875Eco-Vector77510.17816/RCF12422-42ArticlesСтатьиRedox regulation as a platform for search and design of new type drugs. Search of gastroprotectors among sunstituted coumarinsРедокс-регуляция как надёжная платформа поиска и разработки лекарств нового типа. поиск гастропротекторов среди замещённых кумариновParfenovEdgar AndreevichПарфёновЭдгар Андреевич

PhD (Bioorganic Chemistry), Leading Researcher

д. х. н., ведущий научный сотрудник

phcao@yandex.ruTrapkovVladimir AlexandrovichТрапковВладимир Александрович

PhD, Scientific Researcher

к. б. н., научный сотрудник

vnc@pc-club.ruShabanovPetr DmitriyevichШабановПетр Дмитриевич

Dr. Med. Sci. (Pharmacology), Professor and Head, Dept. of Pharmacology

д. м. н., профессор, заведующий кафедрой фармакологии

pdshabanov@mail.ruRussian Cancer Research Center RAMSФГБУ «Российский онкологический научный центр им. Н. Н. Блохина» РАМНAll-Russian Scientific Center on Safety of Biologically Active CompoundsОАО «Всероссийский научный центр по безопасности биологически активных веществ»S. M. Kirov Military Medical AcademyВоенно-медицинская академия им. С. М. Кирова15122014124VOL 12, NO4 (2014)ТОМ 12, №4 (2014)224221102015Copyright ©; 2014, Parfenov E.A., Trapkov V.A., Shabanov P.D.Copyright ©; 2014, Парфёнов Э.А., Трапков В.А., Шабанов П.Д.2014Parfenov E.A., Trapkov V.A., Shabanov P.D.Парфёнов Э.А., Трапков В.А., Шабанов П.Д.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/RCF/article/view/775

Redox homeostasis controls most or all processes of normal and pathological physiology. Important position in the defence mechanisms are redox active metabolites As a robust platform for the development of new effective drugs is not screened, but directed the design and search for low molecular weight metabolites natural redox active compounds. This statement confirms the synthesis and study of new gastroprotektors of complex compounds of copper and zinc with coumarin ligands. On the model of acute ethanol rat gastric ulcer shown that preprocessing all tested complex compounds in equimolar doses of 0.15 mmol/kg leads to a considerable reduction in the size of the damage to the wall of the stomach, compared to control, and sucralfat (for 72,5-87,9 %, sucralfat - 52,3%).

На примере дизайна и поиска эффективных гастропротекторов обоснован механизм редокс-регуляции биологических явлений как надёжной платформы направленной разработки новых лекарств на смену исчерпавших свой потенциал вариантов скрининга. На модели острой этанольной язвы желудка крыс показано, что предобработка всеми испытанными комплексными соединениями кумариновых лигандов меди и цинка в эквимолярных дозах 0,15 ммоль/кг приводит к значительному уменьшению размера повреждения стенки желудка по сравнению с контролем и сукралфатом (на 72,5-87,9 %, сукралфат - 52,3%).

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