Reviews on Clinical Pharmacology and Drug TherapyReviews on Clinical Pharmacology and Drug TherapyОбзоры по клинической фармакологии и лекарственной терапии1683-41002542-1875Eco-Vector79110.17816/RCF11444-53ArticlesСтатьиPharmacology of polyprenols as adaptogens reducing glycation processesФармакология полипренолов как адаптогенов, снижающих интенсивность процессов гликированияBakuninaNatalya SergeyevnaБакунинаНаталья Сергеевна

Fellow, Anichkov Dept. of Neuropharmacology

аспирант отдела нейрофармакологии им. С. В. Аничкова

pdshabanov@mail.ruGlushakovRuslan IvanovichГлушаковРуслан Иванович

PhD, Oncologist

к. м. н., врач онколог-гинеколог

glushakovruslan@gmail.comTapilskayaNatalya IgorevnaТапильскаяНаталья Игоревна

Dr. Med. Sci., Professor, Dept. of Obstetrics and Gynecology

д. м. н., профессор кафедры акушерства и гинекологии с онкологией

ShabanovPetr DmitriyevichШабановПетр Дмитриевич

Dr. Med. Sci. (Pharmacology), Professor and Head, Anichkov Dept. of Neuropharmacology

д. м. н., профессор, заведующий отделом нейрофармакологии им. С. В. Аничкова

pdshabanov@mail.ruInstitute of Experimental Medicine, NWB RAMSФГБУ «Научно-исследовательский институт экспериментальной медицины» СЗО РАМНState Pediatric Medical University of St. PetersburgГБОУ ВПО «Государственная медицинская педиатрическая академия» Министерства здравоохранения РФ15122013114VOL 11, NO4 (2013)ТОМ 11, №4 (2013)445321102015Copyright ©; 2013, Bakunina N.S., Glushakov R.I., Tapilskaya N.I., Shabanov P.D.Copyright ©; 2013, Бакунина Н.С., Глушаков Р.И., Тапильская Н.И., Шабанов П.Д.2013Bakunina N.S., Glushakov R.I., Tapilskaya N.I., Shabanov P.D.Бакунина Н.С., Глушаков Р.И., Тапильская Н.И., Шабанов П.Д.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/RCF/article/view/791

Nowadays a significant attention is currently given to the process of glycation which plays an important role in the pathogenesis of vascular complications of diabetes and different neurodegenerative diseases. As a result of inconvertible transformation of early glycation products, stable compounds with different structure are produced - advanced glycation end-products (AGE), which have special patterns leading to pathological development. There are specific receptors of AGE which include phagocyte receptor, RAGE-receptor for advanced glycation end products, and galectin-3. It is necessary to find methods for prevention of development negative processes induced by glycation. It can be administration of glycation inhibitors or the use of compounds, leading to reduction of the level of glycation products, as well as intensification of metabolic processes, which also promotes reduction of glycation. It can also be inhibition of interlocking with receptor and/or post-receptor signaling pathways, which can theoretically reduce the risk of negative phenomena, induced by glycation products. Polyprenols are biologically highly functional active compounds taking part in the process of polysaccharides, glycoproteins, peptidoglycanes and carbohydrate-containing biopolymers biosynthesis. Polyprenols are perspective drugs that can be applied in various fields of experimental and clinical medicine.

На сегодняшний день большое внимание уделяется процессу гликирования, играющему важную роль в патогенезе сосудистых осложнений сахарного диабета, различных нейродегенеративных заболевниях. В результате необратимых превращений продуктов раннего гликирования образуются стабильные соединения различной структуры - конечные продукты глубокого гликирования (КПГ), обладающие характерными особенностями, приводящими к патологическим проявлениям. К специфическим рецепторам КПГ относятся рецептор фагоцитов, рецептор конечных продуктов гликирования (RAGE - receptor for advanced glycation end products) и галектин-3. Необходимо найти способы предотвращения развития негативных процессов, вызванных гликированием. Они могут заключаться в применении ингибиторов гликирования или в применении веществ, приводящих к снижению уровня продуктов гликирования, также в усилении метаболических процессов, которые могут способствовать снижению уровня гликирования, и в подавлении взаимодействия с рецептором и/или пострецепторных сигнальных путей, которое также теоретически может снизить риск развития негативных явлений, вызванных продуктами гликирования. Полипренолы являются биологически высокофункционально активными веществами, участвующими в процессе биосинтеза полисахаридов, гликопротеидов, пептидогликанов и углеводсодержащих биополимеров, и являются перспективными соединениями, применение которых возможно в различных областях экспериментальной и клинической медицины.

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