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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Family Doctor</journal-id><journal-title-group><journal-title xml:lang="en">Russian Family Doctor</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский семейный врач</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-1668</issn><issn publication-format="electronic">2713-2331</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">653480</article-id><article-id pub-id-type="doi">10.17816/RFD653480</article-id><article-id pub-id-type="edn">QHYMOG</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальное исследование</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Recurrent aphthous stomatitis and associated comorbidities</article-title><trans-title-group xml:lang="ru"><trans-title>Рецидивирующий афтозный стоматит и коморбидная патология</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0006-6222-2452</contrib-id><contrib-id contrib-id-type="spin">8911-6769</contrib-id><name-alternatives><name xml:lang="en"><surname>Klur</surname><given-names>Margarita V.</given-names></name><name xml:lang="ru"><surname>Клур</surname><given-names>Маргарита Вилленовна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><email>Margarita.Кlur@szgmu.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9824-3945</contrib-id><contrib-id contrib-id-type="spin">2496-9920</contrib-id><name-alternatives><name xml:lang="en"><surname>Tokin</surname><given-names>Ivan I.</given-names></name><name xml:lang="ru"><surname>Токин</surname><given-names>Иван Иванович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><email>tokin@influenza.spb.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0003-5272-3470</contrib-id><contrib-id contrib-id-type="spin">6090-5228</contrib-id><name-alternatives><name xml:lang="en"><surname>Davtyan</surname><given-names>Nikolay R.</given-names></name><name xml:lang="ru"><surname>Давтян</surname><given-names>Николай Робертович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>davtyannickolay@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5195-9316</contrib-id><contrib-id contrib-id-type="spin">6562-9851</contrib-id><name-alternatives><name xml:lang="en"><surname>Tsvetkov</surname><given-names>Valeriy V.</given-names></name><name xml:lang="ru"><surname>Цветков</surname><given-names>Валерий Владимирович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>supcolor@gmail.com</email></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-4790-7377</contrib-id><name-alternatives><name xml:lang="en"><surname>Khokhlova</surname><given-names>Anna R.</given-names></name><name xml:lang="ru"><surname>Хохлова</surname><given-names>Анна Робертовна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>anya.davtyan@mail.ru</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">North-Western State Medical University named after I.I. Mechnikov</institution></aff><aff><institution xml:lang="ru">Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Smorodintsev Research Institute of Influenza</institution></aff><aff><institution xml:lang="ru">Научно-исследовательский институт гриппа им. А.А. Смородинцева</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">North-Western State Medical University named after I.I. Mechnikov</institution></aff><aff><institution xml:lang="ru">Северо-Западный государственный медицинский университет им. И.И. Мечникова</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2025-08-11" publication-format="electronic"><day>11</day><month>08</month><year>2025</year></pub-date><pub-date date-type="pub" iso-8601-date="2025-11-14" publication-format="electronic"><day>14</day><month>11</month><year>2025</year></pub-date><volume>29</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>29</fpage><lpage>36</lpage><history><date date-type="received" iso-8601-date="2025-02-05"><day>05</day><month>02</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-08-04"><day>04</day><month>08</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder></permissions><self-uri xlink:href="https://journals.eco-vector.com/RFD/article/view/653480">https://journals.eco-vector.com/RFD/article/view/653480</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold> The prevalence of recurrent aphthous stomatitis approaches 65% and has been progressively increasing in recent decades. Despite numerous research, the causes of this condition remain poorly understood. In recent years, the focus has been on the relationship between recurrent aphthous stomatitis and various infectious and non-infectious diseases that trigger it.</p> <p><bold>AIM:</bold> This study aimed to assess the incidence of recurrent aphthous stomatitis in patients with various oral mucosal diseases, as well as to establish the relationship with various infectious and non-infectious comorbidities.</p> <p><bold>METHODS:</bold> A retrospective analysis of medical records of patients admitted to the S.P. Botkin Clinical Infectious Diseases Hospital between January 2022 and December 2023, with the following secondary diagnosis according to the 10th revision of the International Classification of Diseases: K12 Stomatitis and related lesions. Age- and sex-related characteristics of patients, length of hospital stay, and relationship with infectious and non-infectious diseases were analyzed. The proportion of aphthous stomatitis in oral mucosal diseases was assessed.</p> <p><bold>RESULTS:</bold> The study included medical records of 334 patients. A higher incidence of recurrent aphthous stomatitis was reported in patients with acute upper respiratory tract infections, acute tonsillitis, and disorders complicated by respiratory failure.</p> <p><bold>CONCLUSION:</bold> The findings indicate that infections trigger chronic aphthous stomatitis relapses, confirming the multifactorial nature of the underlying disease.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> Распространенность рецидивирующего афтозного стоматита достигает 65% с неуклонной тенденцией к росту на протяжение последних десятилетий. Несмотря на многочисленные исследования, до сих пор недостаточно ясны основные причины заболевания. В последние годы большая роль отведена взаимосвязи рецидивирующего афтозного стоматита с различными инфекционными и неинфекционными патологиями, запускающими патологический процесс.</p> <p><bold>Цель исследования.</bold> Проанализировать частоту встречаемости рецидивирующего афтозного стоматита у больных различными поражениями слизистой оболочки ротовой полости, а также выявить взаимосвязь заболевания с различными инфекционными и неинфекционными коморбидными патологиями.</p> <p><bold>Методы.</bold> Поведен ретроспективный анализ историй болезни пациентов, госпитализированных в Клиническую инфекционную больницу им. С.П. Боткина с января 2022 г. по декабрь 2023 г. с сопутствующим диагнозом из рубрики Международной классификации болезней 10-го пересмотра «К12 Стоматит и связанные с ним поражения». Анализировали возрастные и половые характеристики пациентов, количество койко-дней и взаимосвязи с коморбидными инфекционными и неинфекционными патологиями. Выявлен удельный вес рецидивирующего афтозного стоматита в структуре поражений слизистой оболочки ротовой полости.</p> <p><bold>Результаты.</bold> Включены истории болезни 334 пациентов. Установлено увеличение частоты встречаемости рецидивирующего афтозного стоматита у больных острой респираторной инфекцией верхних дыхательных путей, острым тонзиллитом, а также у пациентов с заболеваниями, осложненными дыхательной недостаточностью.</p> <p><bold>Заключение.</bold> Полученные данные свидетельствуют о влиянии инфекционной патологии в качестве триггерного фактора на рецидив хронического афтозного стоматита, и подтверждают полиэтиологический характер основного заболевания.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>stomatitis</kwd><kwd>chronic aphthous stomatitis</kwd><kwd>acute respiratory viral infections</kwd><kwd>acute tonsillitis</kwd><kwd>peritonsillar abscess</kwd><kwd>HIV infection</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>стоматит</kwd><kwd>хронический афтозный стоматит</kwd><kwd>острые респираторные вирусные инфекции</kwd><kwd>острый тонзиллит</kwd><kwd>паратонзиллярный абсцесс</kwd><kwd>ВИЧ-инфекция</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Sagimbayeva TB, Tankibaeva ZhG. 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