<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Family Doctor</journal-id><journal-title-group><journal-title xml:lang="en">Russian Family Doctor</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский семейный врач</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2072-1668</issn><issn publication-format="electronic">2713-2331</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">707985</article-id><article-id pub-id-type="doi">10.17816/RFD707985</article-id><article-id pub-id-type="edn">GJGWDZ</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Original study article</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Оригинальное исследование</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Comorbidity in patients with hand osteoarthritis</article-title><trans-title-group xml:lang="ru"><trans-title>Коморбидность у пациентов с остеоартритом суставов кисти</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7389-7846</contrib-id><contrib-id contrib-id-type="spin">6627-3448</contrib-id><name-alternatives><name xml:lang="en"><surname>Filatova</surname><given-names>Tatiana A.</given-names></name><name xml:lang="ru"><surname>Филатова</surname><given-names>Татьяна Анатольевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>tatyanafilatova90@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7241-5059</contrib-id><contrib-id contrib-id-type="spin">7564-3016</contrib-id><name-alternatives><name xml:lang="en"><surname>Dudina</surname><given-names>Olga V.</given-names></name><name xml:lang="ru"><surname>Дудина</surname><given-names>Ольга Владимировна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><email>o-dudina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6457-5044</contrib-id><contrib-id contrib-id-type="spin">3496-2880</contrib-id><name-alternatives><name xml:lang="en"><surname>Shaporova</surname><given-names>Nataliia L.</given-names></name><name xml:lang="ru"><surname>Шапорова</surname><given-names>Наталия Леонидовна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>shapnl@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0004-5966-1935</contrib-id><contrib-id contrib-id-type="spin">9354-8145</contrib-id><name-alternatives><name xml:lang="en"><surname>Iablonskaya</surname><given-names>Vera N.</given-names></name><name xml:lang="ru"><surname>Яблонская</surname><given-names>Вера Николаевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine), Assistant Professor</p></bio><bio xml:lang="ru"><p>канд. мед. наук, доцент</p></bio><email>yavera09@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-0622-1481</contrib-id><contrib-id contrib-id-type="spin">4775-1860</contrib-id><name-alternatives><name xml:lang="en"><surname>Grigoreva</surname><given-names>Evgeniia A.</given-names></name><name xml:lang="ru"><surname>Григорьева</surname><given-names>Евгения Андреевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD</p></bio><email>grigorieva_job@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pavlov First Saint Petersburg State Medical University</institution></aff><aff><institution xml:lang="ru">Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2026-07-01" publication-format="electronic"><day>01</day><month>07</month><year>2026</year></pub-date><pub-date date-type="pub" iso-8601-date="2026-07-23" publication-format="electronic"><day>23</day><month>07</month><year>2026</year></pub-date><volume>30</volume><issue>2</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>87</fpage><lpage>94</lpage><history><date date-type="received" iso-8601-date="2026-05-29"><day>29</day><month>05</month><year>2026</year></date><date date-type="accepted" iso-8601-date="2026-06-02"><day>02</day><month>06</month><year>2026</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2026, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2026, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2026,</copyright-statement><copyright-year>2026</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2029-06-30"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/RFD/article/view/707985">https://journals.eco-vector.com/RFD/article/view/707985</self-uri><abstract xml:lang="en"><p><bold>BACKGROUND:</bold> Over the past few years, many studies have confirmed the role of chronic non-communicable diseases in the risk of hand osteoarthritis development and progression. However, information on the comorbidity profile in patients with hand osteoarthritis is limited to specific diseases, and data on the impact of comorbidity on joint symptoms are lacking.</p> <p><bold>AIM:</bold> To assess comorbidity in patients with hand osteoarthritis and its association with joint symptoms.</p> <p><bold>METHODS:</bold> The study included 101 women. Hand osteoarthritis was confirmed in 70 (69.3%) women, and large-joint osteoarthritis in 31 (30.7%). Among patients with hand osteoarthritis, the most common comorbidities were arterial hypertension (71.4%), obesity (37.1%), degenerative spinal disease (37.1%), osteoporosis (34.3%), pancreatobiliary disease (31.4%), and lower-extremity varicose veins (30.0%). Women with a Charlson Comorbidity Index of 3–4 had more severe night-time hand pain (<italic>p</italic> = 0.034) and a trend toward more severe morning stiffness (<italic>p</italic> = 0.065) than those with an index of 1–2.</p> <p><bold>RESULTS:</bold> 70 (69.3%) women had hand osteoarthritis, and 31 (30.7%) women had osteoarthritis of the large joints. In the structure of concomitant diseases in patients with hand osteoarthritis, the leading positions were occupied by arterial hypertension (71.4%), obesity (37.1%), degenerative disc diseases (37.1%), osteoporosis (34.3%), pancreatobiliary system diseases (31.4%), and lower extremity varicose vein disease (30.0%). Women with a comorbidity index of 3–4 had more severe pain in the hand joints at night (<italic>p</italic> = 0.034) and a tendency of more severe morning stiffness in the hand joints (<italic>p</italic> = 0.065) than women with a comorbidity index of 1–2.</p> <p><bold>CONCLUSION:</bold> Hand osteoarthritis is associated with high comorbidity. The disease is clinically heterogeneous, since patients with a higher Charlson Comorbidity Index experience more severe hand pain.</p></abstract><trans-abstract xml:lang="ru"><p><bold>Обоснование.</bold> За последние несколько лет появилось много публикаций, подтверждающих вклад хронических неинфекционных заболеваний в риск развития и прогрессирования остеоартрита суставов кисти. Однако сведения о структуре сопутствующей патологии у пациентов с остеоартритом данной локализации представлены только для отдельных заболеваний, а о влиянии коморбидного фона на течение суставного синдрома — отсутствуют.</p> <p><bold>Цель исследования.</bold> Оценить коморбидность у пациентов с остеоартритом суставов кисти и ее взаимосвязь с суставным синдромом.</p> <p><bold>Методы.</bold> В одномоментное исследование включены женщины с диагнозом «первичный остеоартрит». Всем пациенткам рассчитан индекс коморбидности Чарлсон. Информация о сопутствующей патологии получена путем сбора анамнеза и анализа медицинской документации. У пациенток с остеоартритом суставов кисти определяли уровень боли и утренней скованности в суставах кисти по визуально-аналоговой шкале. Анализ полученных данных выполняли с использованием параметрических и непараметрических критериев.</p> <p><bold>Результаты.</bold> Включена 101 пациентка. У 70 (69,3%) женщин верифицирован остеоартрит суставов кисти, у 31 (30,7%) женщины — остеоартрит крупных суставов. В структуре сопутствующих заболеваний у пациенток с остеоартритом суставов кисти лидировали по частоте артериальная гипертензия (71,4%), ожирение (37,1%), дегенеративные заболевания позвоночника (37,1%), остеопороз (34,3%), заболевания панкреатобилиарной системы (31,4%) и варикозная болезнь вен нижних конечностей (30,0%). У женщин с индексом коморбидности 3–4 балла наблюдали более выраженные боли в суставах кисти ночью (<italic>р</italic>=0,034) и тенденцию к более выраженной утренней скованности в суставах кисти (<italic>р</italic>=0,065), чем у женщин с индексом коморбидности 1–2 балла.</p> <p><bold>Заключение.</bold> Остеоартрит суставов кисти характеризует высокая коморбидность. Данному заболеванию свойственна клиническая гетерогенность, поскольку у пациентов с бóльшим индексом Чарлсон наблюдают сильнее выраженные боли в суставах кисти.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>hand osteoarthritis</kwd><kwd>comorbidity</kwd><kwd>Charlson Comorbidity Index</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>остеоартрит суставов кисти</kwd><kwd>коморбидная патология</kwd><kwd>индекс коморбидности Чарлсон</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Taskina EA, Lila AM, Kashevarova NG, et al. Osteoarthritis of the hands: epidemiology, risk factors, and modern diagnostics. Modern Rheumatology Journal. 2025;19(4):13–24. doi: 10.14412/1996-7012-2025-4-13-24 EDN: ZJLCWN</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Plotz B, Bomfim F, Sohail MA, Samuels J. Current epidemiology and risk factors for the development of hand osteoarthritis. Curr Rheumatol Rep. 2021;23(8):61. doi: 10.1007/s11926-021-01025-7 EDN: FDAZES</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Shostak NA, Pravdyuk NG, Klimenko AA, et al. Osteoarthritis and associated pathology-clinical and pathogenetic associations. Russian Medical Inquiry. 2019;3(11(2)):44–47. EDN: UEDLQN</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Wang F, Shi L, Xue QY. Association of metabolic factors with symptomatic hand osteoarthritis in the Chinese Han population aged 40 years and above. Chin Med J (Engl). 2016;129(19):2301–2307. doi: 10.4103/0366-6999.190660</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Courties A, Sellam J, Maheu E, et al. Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study. RMD Open. 2017;3(1):e000344. doi: 10.1136/rmdopen-2016-000344 EDN: YYJUNT</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Haugen IK, Ramachandran VS, Misra D, et al. Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham heart study. Ann Rheum Dis. 2015;74(1):74–81. doi: 10.1136/annrheumdis-2013-203789</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Mazurov VI, Lila AM, Togizbaev GA, et al. Eurasian recommendations for the diagnosis and treatment of primary osteoarthritis (2025). League of Eurasian Rheumatologists (LEAR). Modern Rheumatology Journal. 2025;19(4):96–110. doi: 10.14412/1996-7012-2025-4-96-110 EDN: VWBECI</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Charlson ME, Pompei P, Ales KL, MacKenzie CR. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373–383. doi: 10.1016/0021-9681(87)90171-8</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hawker GA, Mian S, Kendzerska T, French M. Measures of adult pain: Visual Analog Scale for Pain (VAS Pain), Numeric Rating Scale for Pain (NRS Pain), McGill Pain Questionnaire (MPQ), Short-Form McGill Pain Questionnaire (SF-MPQ), Chronic Pain Grade Scale (CPGS), Short Form-36 Bodily Pain Scale (SF-36 BPS), and Measure of Intermittent and Constant Osteoarthritis Pain (ICOAP). Arthritis Care Res (Hoboken). 2011;63(Suppl 11):S240–S252. doi: 10.1002/acr.20543</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Mazurov VI, Lila AM, Alekseeva LI, et al. Multimorbidity in osteoarthritis and pleiotropic effects of slow-acting symptomatic drugs. Resolution of the multidisciplinary International Expert Council. Modern Rheumatology Journal. 2023;17(5):123–131. doi: 10.14412/1996-7012-2023-5-123-131 EDN: CVDACN</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Belaya ZhE, Belova KYu, Biryukova EV, et al. Federal clinical guidelines for diagnosis, treatment and prevention of osteoporosis. Osteoporosis and Bone Diseases. 2021;24(2):4–47. doi: 10.14341/osteo12930 EDN: TUONYE</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Alekseeva LI. Osteoarthritis and osteoporosis – two opposites or one entity? Opinion Leader. 2018;(19):32–36. (In Russ.) EDN: NQRVFA</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Zubareva EV, Goncharova МG, Maksimov DM, Lesnyak OM. Clinical and instrumental associations of knee osteoarthrosis and pathology of the veins of the lower extremities. Scientific and Practical Rheumatology. 2021;59(2):184–191. doi: 10.47360/1995-4484-2021-184-191 EDN: NGXMHQ</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Zubareva EV, Lesnyak OM. Do lower extremity varicose veins influence manifestations of knee osteoarthritis? Lechaschi Vrach. 2016;(12):64–67. (In Russ.) EDN: XWQGRP</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Sarvilina IV, Nazarenko AG, Minasov TB, Gromova OA. Generalized osteoarthritis: ways to search effective pharmacotherapy. Lechaschi Vrach. 2024;12(27):86–93. doi: 10.51793/OS.2024.27.12.013 EDN: LBRMQC</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Kraus VB, Jordan JM, Doherty M, et al. The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis Cartilage. 2007;15(2):120–127. doi: 10.1016/j.joca.2006.10.002</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Riyazi N, Rosendaal FR, Slagboom E, et al. Risk factors in familial osteoarthritis: the GARP sibling study. Osteoarthritis Cartilage. 2008;16(6):654–659. doi: 10.1016/j.joca.2007.10.012</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Tsvinger SV, Govorin AV, Romanova EN, Portyannikova OO. The incidence of osteoarthritis and features of the comorbid background in patients seeking medical help for joint pain. Russian Journal of Preventive Medicine and Public Health. 2021;24(1):67–72. doi: 10.17116/profmed20212401167 EDN: JRSWKJ</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Xu Y, Szilagyi IA, Boer CG, et al. Association between thyroid function and osteoarthritis: a population-based cohort study. Osteoarthritis Cartilage. 2025;33(7):888–896. doi: 10.1016/j.joca.2024.10.017 EDN: JJHXBX</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Koo HK, Song P, Lee JH. Novel association between asthma and osteoarthritis: a nationwide health and nutrition examination survey. BMC Pulm Med. 2021;21(1):1–8. doi: 10.1186/s12890-021-01425-6 EDN: MMMPDK</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Kurushina OV, Barulin AYe. Comorbid diseases and pain syndrome: treatment strategies with a focus on nonsteroidal anti-inflammatory drugs. Effective pharmacotherapy. 2025;21(25):106–110. doi: 10.33978/2307-3586-2025-21-25-106-110 EDN: ZAEWVT</mixed-citation></ref></ref-list></back></article>
