Scientific and theoretical prerequisites for the use of plant polysaccharides as medicinal and preventive agents



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The place and role of plant polysaccharides in human life is determined by increasing influence on human health, the processes of conservation and augmentation of human resources. Given the multifunctional nature on human body, it seems advisable to expand the range of studies of natural resources with a high content of them. In this regard, one of ways to implement this direction is to involve scientists in search for new plant resources for isolation of polysaccharides, study of pharmacological action and development of new medicines. The use of plant polysaccharides as medicinal and preventive agents is one of the most sought-after areas in medical practice. Being high-molecular compounds, polysaccharides are formed as result of condensation of monosaccharide residues and derivatives interconnected by glycosidic bonds. A possible tool for improving physico-chemical properties, increasing bioavailability and stability of polysaccharides is chemical modification, an example of which is sulfation. The diversity of our country's natural resources allows us to have constantly renewable sources of plant polysaccharides and ample opportunities to study their pharmacological properties. The review article includes literature sources of a fundamental and applied nature published in bibliographic databases (PubMed, ScienceDirect, Google Scholar, CyberLeninka and еLIBRАRY). The search was carried out using key terms: "plant polysaccharides", "phytopreparations" and "chemical modification of polysaccharides". The review article presents an analysis of data in field of research on plant polysaccharides, which reflects prerequisites for scientific and technological developments for use in pharmaceutical industry in near future. In the process of a comprehensive assessment of use of plant polysaccharides for medicinal and preventive purposes, the points of view of domestic and foreign scientists are presented. All of them come down to the fact that there is an urgent need for a detailed study of physico-chemical properties of individual polysaccharides with pronounced immunomodulatory, antioxidant and prebiotic activity.

 

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Daria Yurievna Makarova

Санкт-Петербургский государственный химико-фармацевтический университет

Author for correspondence.
Email: makarova.darya@spcpu.ru
ORCID iD: 0000-0003-3484-5565
SPIN-code: 3015-9985

Ассистент кафедры промышленной технологии лекарственных препаратов им. Ю.К. Сандера, аспирант

Russian Federation, 197022, г. Санкт-Петербург, вн.тер.г. муниципальный округ Аптекарский остров, ул.Профессора Попова, д.14, литера А.

Irina Evgenievna Kaukhova

Санкт-Петербургский государственный химико-фармацевтический университет

Email: irina.kaukhova@pharminnotech.com
ORCID iD: 0000-0002-0896-6956
SPIN-code: 2931-5790
Scopus Author ID: 6505860165

Профессор кафедры промышленной технологии лекарственных препаратов им. Ю.К. Сандера, доктор фармацевтических наук, профессор 

Russian Federation, 197022, г. Санкт-Петербург, вн.тер.г. муниципальный округ Аптекарский остров, ул.Профессора Попова, д.14, литера А.

Ekaterina Konstantinovna Novikova

Санкт-Петербургский государственный химико-фармацевтический университет

Email: ekaterina.krasova@pharminnotech.com
ORCID iD: 0000-0002-2602-0697
SPIN-code: 3835-2109
Scopus Author ID: 57435178300

Доцент кафедры промышленной технологии лекарственных препаратов им. Ю.К. Сандера, кандидат фармацевтических наук

Russian Federation, 197022, г. Санкт-Петербург, вн.тер.г. муниципальный округ Аптекарский остров, ул.Профессора Попова, д.14, литера А.

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