Genetic predictors of heavy and complicated course of community-acquired pneumonia



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Abstract

The article presents the literature review results of publications dedicated to studies of genetic associations heavy and complicated course of community acquired pneumonia. The methodological basis was the formation of search queries on relevant topics in Russian and English in databases Google Scholar, e-Library, PubMed (MEDLINE). The analyzed studies devoted to a large spectrum of genetic determinants, potentially associated with CAP, the role of some markers are still disputable. This fact creates the need for additional research on the prevalence of ge- netic polymorphisms.

About the authors

Ivan Nikolaevich Gayvoronskiy

S. M. Kirov Military Medical Academy, Saint Petersburg

Author for correspondence.

Yuriy Shavkatovich Khalimov

S. M. Kirov Military Medical Academy, Saint Petersburg

Svetlana Nikolaevna Kolyubaeva

S. M. Kirov Military Medical Academy, Saint Petersburg

References

  1. Schnoor M., Hedicke J., Dalhoff K. et al. Approaches to estimate the population-based incidence of community acquired pneumonia. Journal of Infection. 2007; 55 (3): 233-9.
  2. Ewig S., Birkner N., Strauss R. et al. New perspectives on community-acquired pneumonia in 388 406 patients. Results from a nationwide mandatory performance measurement programme in healthcare quality. Thorax. 2009; 64 (12): 1062-9.
  3. Trowsdale J., Knight J. C. Major histocompatibility complex genomics and human disease. Annual Review of Genomics and Human Genetics. 2013; 14: 301-323.
  4. White S. R., Loisel D. A., Stern R. et al. Human leukocyte antigen-G expression in differentiated human airway epithelial cells: lack of modulation by Th2-associated cytokines. Respiratory research. 2013; 14 (1): 1. doi: 10.1186/1465-9921-14-4.
  5. Tiwari J. L., Terasaki P. I. HLA and disease associations. New York: Springer-Verlag; 2012. 472.
  6. Campbell P. Clinical relevance of human leukocyte antigen antibodies in liver, heart, lung and intestine transplantation. Current opinion in organ transplantation. 2013; 18 (4): 463-9.
  7. Смелая Т., Сальникова Л., Мороз В. и др. Генетический полиморфизм и частота развития осложнений при пневмонии различного генеза. Общая реаниматология. 2011; 7 (2): 10-6.
  8. Страмбовская Н., Говорин А., Витковский Ю. и др. Генетический полиморфизм CD14, TNFα и FCGR2A у больных гриппом A H1N1 в Забайкальском крае. Медицинская иммунология. 2011; 13 (1): 83-6.
  9. Bruhns P., Iannascoli B., England P. et al. Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses. Blood. 2009; 113 (16): 3716-25.
  10. Князева А. С., Страмбовская Н. Н. Частота полиморфизма генов некоторых противовоспалительных цитокинов и FCGR2A (His-166Arg) у больных хронической ишемией головного мозга в Забайкальском крае. Дальневосточный медицинский журнал. 2014; 1: 83-5.
  11. Yee A. M., Phan H. M., Zuniga R. et al. Association between FCGR2A-R131 allotype and bacteremic pneumococcal pneumonia. Clinical infectious diseases. 2000; 30 (1): 25-8.
  12. Yuan F. F., Wong M., Pererva N. et al. Fcgamma RIIA polymorphisms in Streptococcus pneumoniae infection. Immunology and cell biology. 2003; 81 (3): 192-5.
  13. Berdeli A., Celik H. A., Ozyurek R. et al. Involvement of immuno-globulin FCGR2A and FCGR3B gene polymorphisms in susceptibility to rheumatic fever. Clinical biochemistry. 2004; 37 (10): 925-9.
  14. Hubacek J. A., Stuber F., Frohlich D. et al. Gene variants of the bactericidal/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis. Crit. Care Med. 2001; 29 (3): 557-61.
  15. Barber R. C., O’Keefe G. E. Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis. Am. J. Respir. Crit. Care. Med. 2003; 167 (10): 1316-20.
  16. Flores C., Perez-Mendez L., Maca-Meyer N. et al. A common haplotype of the LBP gene predisposes to severe sepsis. Crit. Care Med. 2009; 37 (10): 2759-66.
  17. Sutherland A. M., Walley K. R., Russell J. A. Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults. Crit. Care Med. 2005; 33 (3): 638-44.
  18. Qureshi S., Medzhitov R. Toll-like receptors and their role in experimental models of microbial infection. Genes and immunity. 2003; 4 (2): 87-94.
  19. Байгозина Е. А., Совалкин В. И., Долгих В. Т. Молекулярно-генетические основы патогенеза нозокомиальной пневмонии. Сибирское медицинское обозрение. 2011; 6 (72): 24-7.
  20. Sanchez E., Orozco G., Martin J. Toll-like receptors and human pathology. Inmunologia. 2004; 23 (4): 328-38.
  21. Lorenz E., Mira J. P., Frees K. L. et al. Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock. Arch. Intern. Med. 2002; 162 (9): 1028-32.
  22. Hawn T. R., Verbon A., Lettinga K. D. et al. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires’ disease. J. Exp. Med. 2003; 198 (10): 1563-72.
  23. Сабитова О. Н., Совалкин В. И. Полиморфизм генов и продукция основных иммунорегуляторных цитокинов при внебольничной пневмонии. Омский научный вестник. 2009; 1 (84): 42-4.
  24. Moens L., Van Hoeyveld E., Peetermans W. E. et al. Mannosebinding lectin genotype and invasive pneumococcal infection. Hum. Immunol. 2006; 67 (8): 605-11.
  25. Garcia-Laorden M. I., Sole-Violan J., de Castro F. R. et al. Mannose-binding lectin and mannose-binding lectin- associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. Journal of Allergy and Clinical Immunology. 2008; 122 (2): 368-74.
  26. Yuan F. F., Marks K., Wong M. et al. Clinical relevance of TLR2, TLR4, CD14 and FcγR2A gene polymorphisms in Streptococcus pneumoniae infection. Immunology and cell biology. 2008; 86 (3): 268-70.
  27. Endeman H., Cornips M. C. A., Grutters J. C. et al. The Fcγ receptor IIA-R/R131 genotype is associated with severe sepsis in community-acquired pneumonia. Clinical and Vaccine Immunology. 2009; 16 (7): 1087-90.
  28. Sole-Violan J., García-Laorden M. I., Marcos-Ramos J. A. et al. The Fcγ receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia. Crit. Care Med. 2011; 39 (6): 1388-93.
  29. Arillo Crespo A. Ancizy Irure E. Lorenzo Reparaz V. et al. Evaluation of a program of individual health education in young obese people. Aten Primaria. 1996; 18 (2): 98-100. (In Spanish)
  30. Sole-Violan J., de Castro F. R., García-Laorden M. I. et al. Genetic variability in the severity and outcome of community-acquired pneumonia. Respir. Med. 2010; 104 (3): 440-7.
  31. Kinder B. W., Freemer M. M., King T. E. et al. Clinical and genetic risk factors for pneumonia in systemic lupus erythematosus. Arthritis & Rheumatism. 2007; 56 (8): 2679-86.
  32. Henckaerts L., Nielsen K. R., Steffensen R. et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit. Care Med. 2009; 37 (1): 192-e3.
  33. Martin-Loeches I., Sole-Violan J., de Castro F. R. et al. Variants at the promoter of the interleukin-6 gene are associated with severity and outcome of pneumococcal communityacquired pneumonia. Intensive care med. 2012; 38 (2): 256-62.
  34. Garcia-Laorden M., de Castro F. R., Sole-Violan J. et al. Influence of genetic variability at the surfactant proteins A and D in community-acquired pneumonia: a prospective, observational, genetic study. Crit. Care. 2011; 15 (1): 1. doi: 10.1186/cc10030.
  35. Waterer G. W., ElBahlawan L., Quasney M. W. et al. Heat shock protein 70-2 1267 AA homozygotes have an increased risk of septic shock in adults with community- acquired pneumonia. Crit. Care Med. 2003; 31 (5): 1367-72.

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