The relevance of the study is due to the need to improve objective diagnostic criteria for the relationship of the professional impact of physical overload on the development of polyneuropathies of the upper extremities. The purpose of this study is to determine the characteristics of the effect of physical overload on the state of the vessels of the upper extremities using ultrasound diagnostics. The study was conducted on the basis of the Northwest Scientific Center of Hygiene and Public Health in the period from 2015 to 2019. All patients were aged 44 to 55 years, average age 52 ± 1.3 years, work experience 14.9 ± 2.9 years old. In 36 people (18 men and 18 women), professional polyneuropathy of the upper extremities was revealed due to the influence of physical overloads. For differential diagnosis with no pathology, a control group was composed of 29 people (4 men and 14 women) with a diagnosis of “practically healthy”. The proposed method is intended objective, confirmed by ultrasound methods for the diagnosis of peripheral angioedema of the upper extremities of professional etiology: angioedema syndrome in professional polyneuropathy of the upper extremities due to exposure to physical overload. Using ultrasound of the arteries of the upper extremities, the pulse velocity of blood flow was determined by the ulnar and radial arteries in the distal third of the forearm. As a result, a statistically significant increase in the velocity of blood flow through the ulnar artery was noted. There were no changes in radiation data. The developed method of ultrasound diagnosis of vessels of the upper extremities allows us to find pathognomonic signs for peripheral angioedema of the upper extremities of professional etiology, which can be used in the examination of the connection of existing diseases with a profession related to physical and professional polyneuropathy of the upper extremities, vibration disease associated with the impact of local vibration in the centers professional pathology.