Russian Military Medical Academy ReportsRussian Military Medical Academy Reports2713-23152713-2323Eco-Vector4335510.17816/rmmar43355Research ArticleFACTORS THAT CONTRIBUTE TO REDUCING THE QUALITY OF LIFE OF PATIENTS WITH GLIAL BRAIN TUMORSMurzakanovaD. A-VasiyarovaN. M-BolgarchukO. O-S.M. Kirov Military Medical Academy of the Ministry of Defense13122020391S919428082020Copyright © 2020, Murzakanova D.A., Vasiyarova N.M., Bolgarchuk O.O.2020Neuro-oncological diseases, which often lead to disability of the able-bodied population of developed countries, are one of the most pressing problem of modern medicine. Improving quality of life of neurooncological patients becomes one of the main goals of treatment due to the unfavorable prognosis. In this regard, the purpose of this research was to study factors affecting the quality of life of people with brain tumors in the preoperative period. The study involved 73 patients with gliomas of varying degrees of malignancy before surgery. The quality of life was assessed using the questionnaire "European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire 30". The results of the survey are presented in the form of numerical values for global health, as well as separately on the functional and symptomatic scales. Research on the impact of such parameters as: the preservation of the ability to self-service, involvement in the pathological process of functionally significant areas of the cerebral cortex, the presence of epileptic seizures, on the quality of life was estimated in this article. Participants were divided into groups for each of these characteristics. Statistical analysis was carried out between each of them. Inability to self-care without outside help and involvement of functionally significant areas of the cerebral cortex were associated with a significant decrease in the quality of life on both functional and symptomatic scales. In the presence of epilepsy, regardless of the frequency of seizures, a similar correlation was not observed.EORTC QLQ-C30epilepsybrain tumorsquality of lifeEORTC QLQ-C30questionnairetumor localizationgliomaэпилепсияопухоли головного мозгакачество жизниопросниклокализация опухолиглиома[1. Мартынов, Б.В. Влияние вида и объема хирургического вмешательства на течение послеоперационного периода у больных с гли-альными опухолями / Б.В. Мартынов [и др.] // Бюллетень сибирской медицины. - 2008. - №5(1). - C.231-236.][2. Меликян, Э.Г. Исследование качества жизни больных эпилепсией пожилого возраста с помощью специальных опросников / Э.Г. Меликян [и др.] // Клиническая геронтология. - 2010. - №9-10. - С.52.][3. Перфильев, А.М. Особенности качества жизни у пациентов с супратенториальными опухолями головного мозга // А.М. Перфильев [и др.] // Нейрохирургия. - 2015. - №1. - С.23-28.][4. Cheng, J. Health-related quality of life in glioma patients in China / J. Cheng [et al.] // BMC Cancer. - 2010. - №10. - P.305.][5. Giesinger, J.M. Replication and validation of higher order models demonstrated that a summary score for the EORTC QLQ-C30 is robust / J.M. Giesinger [et al.] // Journal of Clinical Epidemiology. - 2016. - №69. - P.79-88.][6. Giesinger, J.M. Thresholds for clinical importance for four key domains of the EORTC QLQ-C30: physical functioning, emotional functioning, fatigue and pain / J.M. Giesinger [et al.] // Health Qual. Life Outcomes. - 2016. - №14. - P.87.][7. Kristani, M.S. Enhancing the quality of life for palliative care cancer patients in Indonesia through family caregivers: a pilot study of basic skills training / M.S. Kristani [et al.] // BMC Palliat. Care. - 2017. - №16(4). - P.16.][8. Liu, R. Quality of life in adults with brain tumors: Current knowledge and future directions / R. Liu [et al.] // Neuro Oncol. - 2009. - №11(3). - P.330-339.][9. Nolte, S. General population normative data for the EORTC QLQ-C30 health-related quality of life questionnairebased on 15,386 persons across 13 European countries, Canada and the Unites States / S. Nolte [et al.] // European Journal of Cancer. - 2019. - №107. - P.153-163.][10. Osoba, D. Effect of postchemotherapy nausea and vomiting on health-related quality of life. The Quality of Life and Symptom Control Committees of the National Cancer Institute of Canada Clinical Trials Group / D. Osoba [et al.] // Support Care Cancer. - 1997. - №5(4). - P.307-313.][11. Posti, J.P. Presenting symptoms of glioma in adults / J.P. Posti [et al.] // Acta Neurol. Scand. - 2015. - №131(2). - P.88-93.][12. Torre, L.A. Global cancer statistics, 2012 / L.A. Torre [et al.] // CA Cancer J. Clin. - 2015. - №65(2). - P.87-108.]