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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Military Medical Academy Reports</journal-id><journal-title-group><journal-title xml:lang="en">Russian Military Medical Academy Reports</journal-title><trans-title-group xml:lang="ru"><trans-title>Известия Российской Военно-медицинской академии</trans-title></trans-title-group></journal-title-group><issn publication-format="print">2713-2315</issn><issn publication-format="electronic">2713-2323</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">677140</article-id><article-id pub-id-type="doi">10.17816/rmmar677140</article-id><article-id pub-id-type="edn">GKSYHY</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Conference Proceedings</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Материалы конгресса</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Risk factors and differential prevention of in-hospital hemorrhagic stroke</article-title><trans-title-group xml:lang="ru"><trans-title>Факторы риска и дифференцированная профилактика внутригоспитального геморрагического инсульта</trans-title></trans-title-group><trans-title-group xml:lang="zh"><trans-title/></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4163-1701</contrib-id><name-alternatives><name xml:lang="en"><surname>Shermatyuk</surname><given-names>Evgeniy I.</given-names></name><name xml:lang="ru"><surname>Шерматюк</surname><given-names>Евгений Игоревич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Senior Resident</p></bio><bio xml:lang="ru"><p>старший ординатор</p></bio><email>vmeda-nio@mil.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5881-2242</contrib-id><contrib-id contrib-id-type="spin">1006-2845</contrib-id><name-alternatives><name xml:lang="en"><surname>Tsygan</surname><given-names>Nikolay V.</given-names></name><name xml:lang="ru"><surname>Цыган</surname><given-names>Николай Васильевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>vmeda-nio@mil.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-1180-4683</contrib-id><name-alternatives><name xml:lang="en"><surname>Postnov</surname><given-names>Aleksandr A.</given-names></name><name xml:lang="ru"><surname>Постнов</surname><given-names>Александр Алексеевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>6th Year Cadet</p></bio><bio xml:lang="ru"><p>курсант 6-го курса</p></bio><email>vmeda-nio@mil.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7793-4544</contrib-id><contrib-id contrib-id-type="spin">6460-2969</contrib-id><name-alternatives><name xml:lang="en"><surname>Chernenok</surname><given-names>Maxim G.</given-names></name><name xml:lang="ru"><surname>Черненок</surname><given-names>Максим Геннадьевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>2nd Year Resident</p></bio><bio xml:lang="ru"><p>ординатор 2-го года</p></bio><email>vmeda-nio@mil.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0005-4607-1984</contrib-id><name-alternatives><name xml:lang="en"><surname>Medvedev</surname><given-names>Vadim A.</given-names></name><name xml:lang="ru"><surname>Медведев</surname><given-names>Вадим Андреевич</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>5th Year Cadet</p></bio><bio xml:lang="ru"><p>курсант 5-го курса</p></bio><email>vmeda-nio@mil.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2949-6268</contrib-id><name-alternatives><name xml:lang="en"><surname>Sergeeva</surname><given-names>Tatyana V.</given-names></name><name xml:lang="ru"><surname>Сергеева</surname><given-names>Татьяна Васильевна</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Medicine)</p></bio><bio xml:lang="ru"><p>канд. мед. наук</p></bio><email>sergeevatv@eliz-spb.ru</email><xref ref-type="aff" rid="aff2"/><xref ref-type="aff" rid="aff4"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8988-3011</contrib-id><contrib-id contrib-id-type="spin">6112-2792</contrib-id><name-alternatives><name xml:lang="en"><surname>Litvinenko</surname><given-names>Igor V.</given-names></name><name xml:lang="ru"><surname>Литвиненко</surname><given-names>Игорь Вячеславович</given-names></name><name xml:lang="zh"><surname></surname><given-names></given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Medicine), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>vmeda-nio@mil.ru</email><xref ref-type="aff" rid="aff5"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Military Medical Academy</institution></aff><aff><institution xml:lang="ru">Военно-медицинская академия</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">City Hospital of the Holy Martyr Elizabeth</institution></aff><aff><institution xml:lang="ru">Городская больница Cвятой преподобномученицы Елизаветы</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Saint Petersburg State Pediatric Medical University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный педиатрический медицинский университет</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff4"><aff><institution xml:lang="en">Saint Petersburg State University</institution></aff><aff><institution xml:lang="ru">Санкт-Петербургский государственный университет</institution></aff></aff-alternatives><aff-alternatives id="aff5"><aff><institution xml:lang="en">Military Medical Academy</institution></aff><aff><institution xml:lang="ru">Военно-медицинская академия</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2025-11-25" publication-format="electronic"><day>25</day><month>11</month><year>2025</year></pub-date><volume>44</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><issue-title xml:lang="zh"/><fpage>415</fpage><lpage>425</lpage><history><date date-type="received" iso-8601-date="2025-03-13"><day>13</day><month>03</month><year>2025</year></date><date date-type="accepted" iso-8601-date="2025-05-25"><day>25</day><month>05</month><year>2025</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2025, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2025, Эко-Вектор</copyright-statement><copyright-statement xml:lang="zh">Copyright ©; 2025,</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2028-11-25"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/RMMArep/article/view/677140">https://journals.eco-vector.com/RMMArep/article/view/677140</self-uri><abstract xml:lang="en"><p>In-hospital hemorrhagic stroke is a subtype of acute cerebrovascular disease of hemorrhagic origin that includes all forms of non-traumatic intracranial hemorrhage (including subarachnoid hemorrhage) occurring in patients hospitalized for diagnostic evaluation or treatment of another condition, or admitted for a diagnostic or therapeutic procedure. Unlike in-hospital ischemic stroke, the epidemiology of in-hospital hemorrhagic stroke remains insufficiently studied. In-hospital hemorrhagic stroke is a relatively rare competing condition, yet is characterized by a high rate of adverse outcomes (mortality may reach 50%), which may significantly contribute to in-hospital mortality and, similar to in-hospital ischemic stroke, is highly relevant and requires active investigation. In addition to common and specific risk factors, unique risk factors directly related to diagnostic and therapeutic procedures performed in the hospital setting play an important role in the pathogenesis of in-hospital hemorrhagic stroke. This article discusses the most frequent medical procedures associated with the highest risk of in-hospital hemorrhagic stroke, including endovascular surgical interventions, systemic thrombolytic therapy, and antithrombotic therapy. Based on the analysis of risk factors, currently relevant options for differentiated prevention are presented. Recognition of in-hospital hemorrhagic stroke as a distinct clinical condition will enable more effective targeted prevention, reduce in-hospital mortality, and improve clinical outcomes of in-hospital hemorrhagic stroke.</p></abstract><trans-abstract xml:lang="ru"><p>Внутригоспитальный геморрагический инсульт — вариант острого нарушения мозгового кровообращения по геморрагическому типу, включающий все формы нетравматического внутричерепного кровоизлияния (в том числе субарахноидальное кровоизлияние), развившиеся у пациентов, находящихся на стационарном обследовании или лечении по поводу другого заболевания либо госпитализированных для проведения диагностической или лечебной процедуры. В отличие от внутригоспитального ишемического инсульта, эпидемиология внутригоспитальных геморрагических инсультов остается малоизученной. Внутригоспитальный геморрагический инсульт является относительно редкой конкурирующей патологией, однако характеризуется высокой частотой неблагоприятных исходов (летальность может достигать 50%), что может вносить существенный вклад в структуру внутрибольничной летальности и, по аналогии с внутригоспитальным ишемическим инсультом, имеет высокую актуальность и требует активного изучения. В патогенезе внутригоспитального геморрагического инсульта помимо общих и специфических факторов риска важную роль играют уникальные факторы риска, непосредственно связанные с проводимыми в стационаре лечебно-диагностическими мероприятиями. В статье рассматриваются наиболее частые лечебные процедуры, проведение которых сопровождается наибольшим риском развития внутригоспитального геморрагического инсульта — эндоваскулярные хирургические вмешательства, системная тромболитическая терапия, антитромботическая терапия. На основе анализа факторов риска представлены современные возможности дифференцированной профилактики. Выделение внутригоспитального геморрагического инсульта в отдельную форму создаст условия для его более эффективной дифференцированной профилактики, что позволит снизить показатели внутрибольничной летальности и улучшить исходы внутригоспитального геморрагического инсульта.</p></trans-abstract><trans-abstract xml:lang="zh"><p/></trans-abstract><kwd-group xml:lang="en"><kwd>hypertension</kwd><kwd>in-hospital mortality</kwd><kwd>in-hospital hemorrhagic stroke</kwd><kwd>in-hospital ischemic stroke</kwd><kwd>hemorrhagic stroke</kwd><kwd>drug-induced thrombocytopenia</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>внутрибольничная летальность</kwd><kwd>внутригоспитальный геморрагический инсульт</kwd><kwd>внутригоспитальный ишемический инсульт</kwd><kwd>геморрагический инсульт</kwd><kwd>лекарственно-индуцированная тромбоцитопения</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Korkhmazov VT. 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