PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY

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Abstract


A photosensitizer from polycationic metallophthalocyanines class is shown to have a high antimicrobial activity and a wide antimicrobial spectrum. It is established that the effective pho- todynamic inactivation of bacteria in the presence of photosensitizer of polycationic nature is determined by its electrostatic binding to negatively charged structures of bacterial cell walls. The usage of antimicrobial photodynamic therapy in medical practice is discussed from the point of view of the obtained results.

ПЕРСПЕКТИВНЫЙ ФОТОСЕНСИБИЛИЗАТОР ДЛЯ АНТИМИКРОБНОЙ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ

M G Strakhovskaya

Email: maristra@yandex.ru

N S Belenikina

Email: nata.belenikina@ya.ru

V V Nikitina

Email: valentinacheb.ru@mail.ru

S Yu Kovalenko

Email: zaylanka@gmail.com

I B Kovalenko

Email: ikovakenko78@gmail.com

A V Averyanov

Email: averyanovav@mail.ru

A B Rubin

Email: rubin@biophys.msu.ru

T V Galochkina

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  7. Kuznetsova N.A., Yuzhakova O.A., Strakhovskaya M.G., et al. New heterogeneous photosensitizers with phthalocyanine molecules covalently linked to aminopropyl silica gel. Journal of Porphyrins and Phthalocyanines 2011; 15: 718-726.

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Copyright (c) 2013 Strakhovskaya M.G., Belenikina N.S., Nikitina V.V., Kovalenko S.Y., Kovalenko I.B., Averyanov A.V., Rubin A.B., Galochkina T.V.

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