PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY

M G Strakhovskaya; Страховская Марина Глебовна; N S Belenikina; Беленикина Наталья Серафимовна; V V Nikitina; Никитина Валентина Васильевна; S Yu Kovalenko; Коваленко Светлана Юрьевна; I B Kovalenko; Коваленко Илья Борисович; A V Averyanov; Аверьянов Александр Вячеславович; A B Rubin; Рубин Андрей Борисович; T V Galochkina; Галочкина Татьяна Владимировна

doi:10.17816/clinpract4125-30

PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY

Authors: Strakhovskaya MG¹, Belenikina NS¹, Nikitina VV¹, Kovalenko SY.¹, Kovalenko IB¹, Averyanov AV¹, Rubin AB¹, Galochkina TV¹
Affiliations:
Issue: Vol 4, No 1 (2013)
Pages: 25-30
Section: Articles
Submitted: 16.03.2018
Published: 15.03.2013
URL: https://clinpractice.ru/clinpractice/article/view/8246
DOI: https://doi.org/10.17816/clinpract4125-30
ID: 8246

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Abstract

A photosensitizer from polycationic metallophthalocyanines class is shown to have a high antimicrobial activity and a wide antimicrobial spectrum. It is established that the effective pho- todynamic inactivation of bacteria in the presence of photosensitizer of polycationic nature is determined by its electrostatic binding to negatively charged structures of bacterial cell walls. The usage of antimicrobial photodynamic therapy in medical practice is discussed from the point of view of the obtained results.

Keywords

photosensitizer, reactive oxygen species, antimicrobial photodynamic therapy

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ПЕРСПЕКТИВНЫЙ ФОТОСЕНСИБИЛИЗАТОР ДЛЯ АНТИМИКРОБНОЙ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ

References

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Raetz C.R., Reynolds C.M., Trent M.S. et al. Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem 2007; 76: 295-329.
Hamblin M.R., Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004; 3: 436-450.
Макаров Д.А., Кузнецова Н.А., Страховская М.Г. и др. Поликатионные фталоцианины цинка и алюминия: синтез, влияние степени замещения на физико-химические свойства и фотодинамическую активность в водной среде. Журнал физической химии 2009; 6: 1183-1190.
Kuznetsova N.A., Yuzhakova O.A., Strakhovskaya M.G., et al. New heterogeneous photosensitizers with phthalocyanine molecules covalently linked to aminopropyl silica gel. Journal of Porphyrins and Phthalocyanines 2011; 15: 718-726.

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PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY

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