PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY

Cover Page


Cite item

Full Text

Abstract

A photosensitizer from polycationic metallophthalocyanines class is shown to have a high antimicrobial activity and a wide antimicrobial spectrum. It is established that the effective pho- todynamic inactivation of bacteria in the presence of photosensitizer of polycationic nature is determined by its electrostatic binding to negatively charged structures of bacterial cell walls. The usage of antimicrobial photodynamic therapy in medical practice is discussed from the point of view of the obtained results.

Full Text

ПЕРСПЕКТИВНЫЙ ФОТОСЕНСИБИЛИЗАТОР ДЛЯ АНТИМИКРОБНОЙ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ
×

References

  1. Jori G., Brown S.B. Photosensitized inactivation of microorganisms. Photochem Photobiol Sci 2004; 3: 403-405.
  2. Nitzan Y., Gutterman M., Malik Z., et al. Inactivation of gram-negative bacteria by photosensitized porphyrins. Photochem Photobiol 1992; 55: 89-96.
  3. Raetz C.R., Ulevitch R.J., Wright S.D., et al. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 1991; 5: 2652-60.
  4. Raetz C.R., Reynolds C.M., Trent M.S. et al. Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem 2007; 76: 295-329.
  5. Hamblin M.R., Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004; 3: 436-450.
  6. Макаров Д.А., Кузнецова Н.А., Страховская М.Г. и др. Поликатионные фталоцианины цинка и алюминия: синтез, влияние степени замещения на физико-химические свойства и фотодинамическую активность в водной среде. Журнал физической химии 2009; 6: 1183-1190.
  7. Kuznetsova N.A., Yuzhakova O.A., Strakhovskaya M.G., et al. New heterogeneous photosensitizers with phthalocyanine molecules covalently linked to aminopropyl silica gel. Journal of Porphyrins and Phthalocyanines 2011; 15: 718-726.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2013 Strakhovskaya M.G., Belenikina N.S., Nikitina V.V., Kovalenko S.Y., Kovalenko I.B., Averyanov A.V., Rubin A.B., Galochkina T.V.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 38032 от 11 ноября 2009 года.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies