IMMUNOLOGICAL DISODERS IN PATIENTS WITH CHRONIC RENAL INSUFFICIENCY AND POSSIBILITY OF IMMUNE THERAPY

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Abstract

The main evidence of the participation of immune responses in the pathogenesis of chronic renal failure (CRF) is an undoubted effect of treatment with corticosteroids, alkylating agents and cyclosporine A. This is supported by the relationship of nephrotic syndrome (NS) with atopy, Hodgkin's disease, certain HLA-types: DRw7, B12.This article presents a review of the literature, focused on the immunological changes in patients with impaired renal function, including сhroniс hemodialysis. Various aspects of immunocorrection in patients with chronic kidney disease are analyzed.

References

  1. Длин В.В. Патогенетическое значение персистирующей вирусной инфекции при гломерулонефрите у детей в обосновании противовирусной и иммуномодулирующей терапии. Дис. докт. мед. наук, М., 1993.
  2. Доломанова О.Е. Иммуноцитологические особенности и чувствительность к цитотоксическим препаратам у детей с первичным хроническим гломерулонефритом. Автореф. дис.. канд. мед. наук, М., 1991.
  3. Земсков A.M., Караулов А.В., Земсков В.М. Комбинированная иммунокоррекция. М., 1994; 260c.
  4. Ракитинская И.А. Иммунология нефротического синдрома. В кн. Нефротический синдром., СПб., 1992; 33-55.
  5. Цыгин А.Н. Патогенетические основы первичного нефротического синдрома и лечения его тероидорезистентных вариантов у детей. Дис. канд. мед. наук. М., 1996.
  6. Baud L., Fouqueray B., Bellocq A. Switching off renal inflammation by anti-inflammatory mediators: The facts, the promise and hope. Kidney Intern. 1998; 53:1118-26.
  7. Broyer M., Meyrier A., Niaudet P., Habib R. Minimal changes and focal segmental glomerular sclerosis. In: Clinical Nephrology, Ed. Davidson et al, Oxford, 1998; V.I; 1-3; 493-536
  8. Cambon-Thomsen A., Bouissou F., Abbal M., et al. HLA and В12 in idiopathic nephrotic syndrome of children. Differences between steroid sensitive and steroid resistant patients. Pathol Biol. 1986; 34: 725-30.
  9. Chang G.C., Wu C.L. et al. The diagnosis of pneumonia in renal transplantant recipients using invasive and noninvasive procedures. Chest. 2004 Feb; 125 (2): 541-7.
  10. Chen W.P., Lin С.Y. Augmented expression of interleukin-6 and interleukin-1 genes in the mesangium of IgM mesangial nephropathy. Nephron, 1994; 68: 10-19.
  11. Cho B.S., Yoon S.R., Jang J.Y., et al. Up-regulation of interleukin-4 and CD23/Fc.RII in minimal change nephrotic syndrome. Pediatr Nephrol. 1999; 13:199-204.
  12. Colin B.A., Ramphal R. Pneumonia in the compromised host including cancer patientsand tranplantant patients. Infect Dis Clin North Am. 1998. Vol. 12. P. 781 - 805.
  13. Daniel V., Trautmann Y., Konrad M., Nayir A, Scharer K. T-lymphocyte populations, cytokins and other growth factors in serum and urine of children with idiopathic nephrotic syndrome. Clin Nephrol, 1997; 47 (5); 289-97.
  14. Schnaper H.W. The immune system in minimal change nephrotic syndrome. Pediatric Nephrol. 1989; 3:101-10.
  15. Garin Е.H., Laflam P., Chandler L. Anti-interieukin-8 antibody abolishes effects oflipoid nephrosis cytokine. Pediatr Nephrol. 1998; 12: 381-5.
  16. Hewitt I.K., House A.K., Potter J.M., Kinnear B.F. Altered in vitro lymphocyte response in childhood nephrotic syndrome. Pediatr. Nephrol., 1992; 6; 464-6.
  17. Holdsworth S.R., Kitching A.R., Tipping P.G. Thl and Th2 T helper cell subsets affect patterns of injury and outcomes in glomerulonephritis. Kidney Intern. 1999; 55 :1198-1216.
  18. Hulton S.A., Shan V., Byrne M.R., Morgan G., Barrat T.M., Dillon M.J. Lymphocyte subpopulations, interleukin-2 and interleukin-2 receptor expression in childhood nephrotic syndrome. Pediatr Nephrol. 1994; 8:135-9.
  19. Kawaguchi H., Yamaguchi Y., Nagata M., et al. The effects of human recombinant interleukin-2 on the permeability of glomerular basement membranes in rats. Japanese J Nephrol. 1987; 29:1-11.
  20. Kobayashi Y., Yoshikawa N., Nakamura H. T-cell subpopulations in childhood nephrotic syndrome. Clin Nephrol. 1994; 41: 253-8.
  21. Lin С.Y., Chen C.H., Lee P.P. In vitro B-lymphocyte switch disturbance from IgM into IgG in IgM mesangial nephropathy. Pediatr Nephrol. 1989; 3: 254-8.
  22. Matsumoto K., Ohi H., Kanmatsuse K. Interleukin 10 and interleukin 13 synergise to inhibit vascular permeability factor by periferal blood mononuclear cells from patients with lipoid nephrosis. Nephron, 1997; 77: 212-18.
  23. Moorthy A.V., Zimmerman S.W., Burkholder P.M. Ingibitions of lymphocyte blastogenesis by plasma of patients with minimal change nephrotic syndrome. Lancet, 1976; 1 (7970): 1160-2.
  24. Murer L. Focal segmental glomerular sclerosis of native and grafted kidney. Invited lecture, 34th Ann. Meeting of the ESPN, Helsinki, 2000.
  25. Neuhaus T.J., Wadhwa M., Callard R., Barrat T.M. Increased IL-2, IL-4 and interferon-gamma in steroid-sensitive nephrotic syndrome. Clin Exp Immunol. 1995; 100: 475-9.
  26. Pirotski E., Pintos-Morell G., Burtin G., et al. Renal anaphylaxis. I. Antigen-initiated responses from isolated perfused rat kidney. Kidney Int. 1987; 32: 233-7.
  27. Rano A., et al. Pulmonary infiltrates in non-HIV immunocompromised patients: a diagnostic approach using non-invasive and bronchoscopic procedures. Thorax. 2001. Vol. 56. P. 379 - 87.
  28. Reeves W.G., Cameron J.S., Johansson I.G., et al. Seasonal nephrotic syndrome. Description and immunological findings. Clin Allergy, 1975; 5:121-37.
  29. Shalhoub R.J. Pathogenesis of lipoid nephrosis a disorder of T-cell function. Lancet, 1974; 2(7880): 556-60.
  30. Sileri P., Pursell K. J., et al. A standardized protocol of the treatment of severe pneumonia in kidney transplantant recipients. Clin Transplant. 2002;16: 450-1.
  31. Stacbowski J., Michalkiewicz J., Krynicki T. et al. Does disregulation of lymphokine production (IL-2, IL-4, IL-6, IFN-gamma) contribute to the suppressorinducer CD45 RA+ CD4+) and suppressor effector (CD45 RA+ CD8+) T cell activity in primary nephrotic syndrome. Abstr. 27th Ann. Meet. ESPN, 1993, F8.
  32. Stefanovic V., Golubovic E., Mitic-Zlatkovic M., Vlanovic P., Jovanovic O., Bogdanovic R. Interleukin-12 and interferon-gamma production in childhood idiopathic nephrotic syndrome. Pediatr Nephrol. 1998; 12: 463-6.
  33. Yap H.K., Cheung W., Murugasu B., Jordan S.C. Downregulation of monokine genes in children with relapses of steroid-responsive nephrotic syndrome. Abstr. 1th Congress of IPNA, London, 1998.
  34. Yokoyama H.M., et al. Immunodinamics of minimal change nephrotic syndrome in adults.T and В lymphocyte subsets and serum immunoglobulin levels. Clin Exp Immunol. 1985; 61: 601-7.
  35. Zoch-Zwierz W., Wiercinski K., Zwierz K., Wasilewska A. Serum IgE, interleukine-2 and 4 and their soluble receptors in children with nephrotic syndrome. Abstr. 1th Congress of IPNA, London, 1998; 17; 103.

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