Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector1049510.17816/ecogen17359-73Genetic basis of ecosystems evolutionГенетические основы эволюции экосистемResearch ArticleSaccharomyces cerevisiae killer toxins: synthesis, mechanisms of action and practical useКиллер-токсины дрожжей saccharomyces cerevisiae: синтез, механизмы действия и практическое использованиеhttps://orcid.org/0000-0003-0837-04986603061322H-6895-20138281-8020SambukElena V.СамбукЕлена Викторовна
Russian Federation

Associate Professor, Professor of the Department of Genetics and Biotechnology

доцент, профессор кафедры Генетики и биотехнологии

esambuk@mail.ruMuzaevDmitry M.МузаевДмитрий Михайлович
Russian Federation

engineer

инженер

dmmuzaev@yandex.ruhttps://orcid.org/0000-0002-1744-3890553706588009335-1184RumyantsevAndrey M.РумянцевАндрей Михайлович
Russian Federation

junior research assistant

младший научный сотрудник

rumyantsev-am@mai.ruhttps://orcid.org/0000-0002-4051-483766025967557709-0449PadkinaMarina V.ПадкинаМарина Владимировна
Russian Federation

Associate Professor, Professor of the Department of Genetics and Biotechnology

доцент, профессор кафедры Генетики и биотехнологии

mpadkina@mail.ruSaint-Petersburg State UniversityФедеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный университет"290520191509201917359732311201829052019Copyright ©; 2019, Sambuk E.V., Muzaev D.M., Rumyantsev A.M., Padkina M.V.Copyright ©; 2019, Самбук Е.В., Музаев Д.М., Румянцев А.М., Падкина М.В.2019Sambuk E.V., Muzaev D.M., Rumyantsev A.M., Padkina M.V.Самбук Е.В., Музаев Д.М., Румянцев А.М., Падкина М.В.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/10495

Yeast Saccharomyces cerevisiae is a unique model for studying the molecular mechanisms of exotoxin-mediated antagonistic relationships between coexisting microorganisms. The synthesis of yeast toxins can be considered as an example of allelopathy and environmental competition. The elucidation of the role of allelopathy in the formation of microbial communities is of great interest for modern ecology. Yeast toxins are widely used in medicine, the food industry and biotechnology. The review examines the nature of exotoxins, the mechanisms of inheritance and interaction of the virus and yeast cells, as well as the prospects for their practical application.

Дрожжи Saccharomyces cerevisiae, секретирующие токсины различной природы, являются уникальной моделью для изучения молекулярных механизмов антагонистических взаимоотношений сосуществующих микроорганизмов. Синтез дрожжевых токсинов можно рассматривать как пример аллелопатии и экологической конкуренции. Выяснение роли аллелопатии в формировании микробных сообществ представляет большой интерес для современной экологии. Дрожжевые токсины широко используются в медицине, пищевой промышленности и биотехнологии. В обзоре рассмотрены природа экзотоксинов, механизмы наследования и взаимодействия вируса и клеток дрожжей, а также перспективы их практического применения.

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