Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector1105810.17816/ecogen17399-110Human ecological geneticsЭкологическая генетика человекаResearch ArticleSensitive to the effects of environmental factors miR-638 and common diseasesЧувствительная к воздействию средовых факторов miR-638 и многофакторные заболеванияhttps://orcid.org/0000-0003-3824-36417004507293A-7789-20145251-2055KucherAksana N.КучерАксана Николаевна
Russian Federation

Leading Researcher of the Laboratory of Population Genetics, Doctor of Biological Sciences, Professor

доктор биологических наук, профессор, ведущий научный сотрудник лаборатории популяционной генетики

aksana.kucher@medgenetics.ruhttp://www.medgenetics.ru/science/lpg1/personallpg/201590/Research Institute of Medical Genetics, Tomsk NRMCНИИ медицинской генетики Томского национального исследовательского медицинского центра РАН1505201915092019173991101302201915052019Copyright ©; 2019, Kucher A.N.Copyright ©; 2019, Кучер А.Н.2019Kucher A.N.Кучер А.Н.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/11058

The review provides information on environmental factors affecting the level of miR-638 in humans, potential target genes of this micro-RNA (according to “TargetScanHuman”), diseases and metabolic pathways which potentially regulated miR-638, as well as clinical and experimental data confirming the involvement of miR-638 in the developing a wide range of multifactorial diseases. The data presented in the review expand the understanding of the pathogenesis of various diseases of a multifactorial nature and determine new strategies for studying gene-environment interactions that are important for the formation of health.

В обзоре представлена информация о средовых факторах, влияющих на уровень miR-638 в организме человека, потенциальных генах-мишенях данной микроРНК (по TargetScanHuman), заболеваниях и метаболических путях, для которых среди ассоциированных генов избыточно представлены гены, потенциально регулируемые miR-638, а также клинические и экспериментальные данные, подтверждающие вовлеченность miR-638 в развитие широкого спектра многофакторных заболеваний. Приведенные в обзоре сведения расширяют представления о патогенезе различных болезней многофакторной природы и определяют новые стратегии изучения ген-средовых взаимодействий, значимых для формирования здоровья.

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