Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector1158810.17816/ecogen17491-102Human ecological geneticsЭкологическая генетика человекаResearch ArticleEffects of the intestinal microbiota on epigenetic mechanisms involved in the development of post-stress neuro-inflammationЭпигенетический механизм влияния микробиоты кишечника на развитие постстрессорного нейровоспаленияhttps://orcid.org/0000-0002-0140-307757202052229J-3626-20181160-1915ShalaginovaIrina G.ШалагиноваИрина Геннадьевна
Russian Federation

Senior Lecturer, School of Life Science

старший преподаватель, Институт живых систем

shalaginova_i@mail.ruhttps://orcid.org/0000-0002-3174-15606507748788F-3003-20164756-7437MatskovaLiudmila V.МацковаЛюдмила Валентиновна
Russian Federation

PhD, professor-researcher, Microbiology and Biotechnology Unit of School of Life Science

кандидат биологических наук, профессор-исследователь, отдел микробиологии и биотехнологии Института живых систем

liudmila.matskova@ki.seGunitsevaNatalia M.ГуницеваНаталья Михайловна
Russian Federation

student in Bioengineering and bioinformatics, School of Life Science

студентка специальности биоинженерия и биоинформатика, Институт живых систем

nat-gun@mail.ruhttps://orcid.org/0000-0001-5480-164578014657982378-7129VakoliukIrina A.ВаколюкИрина Анатольевна
Russian Federation

PhD, associate professor, School of Life Science

кандидат биологических наук, доцент, Институт живых систем.

vakoluk@mail.ruImmanuel Kant Baltic Federal UniversityФГАОУ ВО «Балтийский федеральный университет имени Иммануила Канта»Immanuel Kant Baltic Federal University  ФГАОУ ВО «Балтийский федеральный университет имени Иммануила Канта»2009201915122019174911020204201920092019Copyright ©; 2019, Shalaginova I.G., Matskova L.V., Gunitseva N.M., Vakoliuk I.A.Copyright ©; 2019, Шалагинова И.Г., Мацкова Л.В., Гуницева Н.М., Ваколюк И.А.2019Shalaginova I.G., Matskova L.V., Gunitseva N.M., Vakoliuk I.A.Шалагинова И.Г., Мацкова Л.В., Гуницева Н.М., Ваколюк И.А.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/11588

A number of alleles of polymorphic genes, dysfunctions of the hypothalamic-pituitary-adrenal axis, neurotransmitter disorders, and manifestations of immune dysregulation are associated with vulnerability to stress. Post-stress states of humans and animals are accompanied by signs of neuroinflammation, the causes and mechanisms of which remain to be elucidated. The article discusses epigenetic mechanisms by which the intestinal microbiota might participate in the initiation and maintenance of post-stress inflammation.

С уязвимостью к стрессу ассоциирован ряд аллелей полиморфных генов, а также дисфункции гипоталамо-гипофизарно-надпочечниковой оси, нейромедиаторные нарушения и проявления иммунной дисрегуляции. Есть убедительные доказательства наличия признаков нейровоспаления при постстрессорных состояниях человека и животных. Причины и механизмы таких нейроиммунных дисфункций не выяснены. В статье рассматривается возможность участия микробиоты кишечника в инициации и поддержании постстрессорного воспаления через эпигенетические механизмы.

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