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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Ecological genetics</journal-id><journal-title-group><journal-title xml:lang="en">Ecological genetics</journal-title><trans-title-group xml:lang="ru"><trans-title>Экологическая генетика</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1811-0932</issn><issn publication-format="electronic">2411-9202</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">2479</article-id><article-id pub-id-type="doi">10.17816/ecogen13236-57</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Genetically modified microorganisms as producers of biologically active compounds</article-title><trans-title-group xml:lang="ru"><trans-title>Генетически модифицированные микроорганизмы - продуценты биологически активных соединений</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Padkina</surname><given-names>Marina Vladimirovna</given-names></name><name xml:lang="ru"><surname>Падкина</surname><given-names>Марина Владимировна</given-names></name></name-alternatives><bio xml:lang="en"><p>Dept. Of Genetics and Biotechnology</p></bio><bio xml:lang="ru"><p>д. б. н., профессор, кафедра генетики и биотехнологии</p></bio><email>mpadkina@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sambuk</surname><given-names>Elena Viktorovna</given-names></name><name xml:lang="ru"><surname>Самбук</surname><given-names>Елена Викторовна</given-names></name></name-alternatives><bio xml:lang="en"><p>Dept. Of Genetics and Biotechnology</p></bio><bio xml:lang="ru"><p>д. б. н., профессор, кафедра генетики и биотехнологии</p></bio><email>esambuk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">St. Petersburg State University</institution></aff><aff><institution xml:lang="ru">СПбГУ</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2015</year></pub-date><volume>13</volume><issue>2</issue><issue-title xml:lang="en">VOL 13, NO2 (2015)</issue-title><issue-title xml:lang="ru">ТОМ 13, №2 (2015)</issue-title><fpage>36</fpage><lpage>57</lpage><history><date date-type="received" iso-8601-date="2016-03-30"><day>30</day><month>03</month><year>2016</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Padkina M.V., Sambuk E.V.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Падкина М.В., Самбук Е.В.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Padkina M.V., Sambuk E.V.</copyright-holder><copyright-holder xml:lang="ru">Падкина М.В., Самбук Е.В.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">http://creativecommons.org/licenses/by/4.0</ali:license_ref></license></permissions><self-uri xlink:href="https://journals.eco-vector.com/ecolgenet/article/view/2479">https://journals.eco-vector.com/ecolgenet/article/view/2479</self-uri><abstract xml:lang="en"><p>In the review the data on use of genetically modified microorganisms as producers of proteins of different organisms are presented. The relative advantages and disadvantages of bacterial and yeast systems for heterologous genes expression are considered.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре представлены данные об использовании генетически модифицированных микроорганизмов в качестве продуцентов белков разных организмов. Рассмотрены достоинства и недостатки бактериальных и дрожжевых систем экспрессии гетерологичных генов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>genetically modified microorganisms</kwd><kwd>heterologous gene expression</kwd><kwd>heterologous proteins</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>генетически модифицированные микроорганизмы</kwd><kwd>экспрессия гетерологичных генов</kwd><kwd>гетерологичные белки</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Глумсков В. (2007) Мировой фармацевтический рынок: состояние и тенденции // Рецепт. № 4 (54). 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