Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector4236310.17816/ecogen42363Human ecological geneticsЭкологическая генетика человекаResearch ArticleExamination of the working environment genotoxic effects on the workers of a coal-fired power plant using the micronucleus test in blood lymphocytesИзучение генотоксических эффектов действия производственной среды на рабочих угольной теплоэлектростанции с помощью микроядерного теста на лимфоцитах кровиhttps://orcid.org/0000-0002-5359-38451473-4062FedoseevVladislav I.ФедосеевВладислав Игоревич
Russian Federation

An engineer-technologist of the cytogenetics laboratory

Инженер-технолог лаборатории цитогенетики

fedoseev.vlig@gmail.com3649-1860StepanovDanil D.СтепановДанил Дмитриевич
Russian Federation

student

студент

StepanovDanil98@yandex.ruhttps://orcid.org/0000-0003-3485-91235153-8594MininaVarvara I.МининаВарвара Ивановна
Russian Federation

Dr. Sci. (Biol.)

д-р биол. наук

vminina@mail.ruFederal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of SciencesФедеральное государственное бюджетное учреждение науки Институт экологии человека Федерального исследовательского центра угля и углехимии Сибирского отделения Российской академии наукKemerovo State UniversityФедеральное государственное бюджетное образовательное учреждение высшего образования «Кемеровский государственный университет»100320211503202119177881408202010032021Copyright ©; 2021, Fedoseev V.I., Stepanov D.D., Minina V.I.Copyright ©; 2021, ООО "Эко-Вектор"2021Fedoseev V.I., Stepanov D.D., Minina V.I.ООО "Эко-Вектор"https://journals.eco-vector.com/ecolgenet/article/view/42363

BACKGROUND: The micronucleus test of peripheral blood lymphocytes provides a qualitative assessment of the state of the genome. A study was carried out aimed at studying the influence of factors of the working environment of coal-fired power plants on the state of the DNA of working data of enterprises.

MATERIALS AND METHODS: Using a micronucleus test with a cytochalasin block on human blood lymphocytes in vitro, 116 men were examined: 45 employees of the Novo-Kemerovo coal-fired power plant and 71 healthy residents of the Kemerovo region.

RESULTS: An increase in the frequency of occurrence of cells with micronuclei, bridges and protrusions in the blood lymphocytes of workers of a coal-fired power plant in comparison with healthy residents of the same area was found.

CONCLUSION: The data confirm the existing idea of the potential danger of combustion products for human health.

Введение. Микроядерный тест на лимфоцитах периферической крови позволяет судить о кластогенных эффектах воздействия факторов окружающей и производственной среды на геном человека.

Материалы и методы. Используя микроядерный тест с цитохалазиновым блоком in vitro, были обследованы 116 мужчин: 45 сотрудников Ново-Кемеровской угольной ТЭЦ и 71 здоровый житель Кемеровской области (не работают на производстве).

Результаты. Установлено повышение частоты встречаемости клеток с микроядрами, мостами и протрузиями у рабочих по сравнению со здоровыми жителями той же местности.

Обсуждение. Полученные данные подтверждают существующее представление о потенциальной опасности угольной энергетики для здоровья человека и обосновывают необходимость модернизации существующих производств и целесообразность дальнейшего перехода к другим источникам энергии.

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