Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector538910.17816/ecogen8224-28ArticlesСтатьиResearch ArticleAssociation of apoprotein A-1 genetic variants with atherosclerosis development in Saint-PetersburgАССОЦИАЦИИ ГЕНЕТИЧЕСКИХ ВАРИАНТОВ АПОПРОТЕИНА А1 С РАЗВИТИЕМ АТЕРОСКЛЕРОЗА У ЖИТЕЛЕЙ САНКТПЕТЕРБУРГАMiroshnikovaValentina VМирошниковаВалентина Вадимовнаmutantropol@mail.ruRodyginaTatyana IРодыгинаТатьяна Ивановнаt_rodygina@mail.ruDeminaEkaterina PДеминаЕкатерина Петровнаcitritt@gmail.comKuryanovPavel SКурьяновПавел Сергеевичpkurjanov@gmail.comUrazgildeevaSoreya AУразгильдееваСорейя Асафовнаs_urazgildeeva@hotmail.comGurevichVictor SГуревичВиктор Савельевичater@med122.comSchwarzmanAlexander LШварцманАлександр Львовичaschwart1@yandex.ruB.P. Konstantinov Nuclear Physics Institute, Gatchina, Leningrad Oblast, RFПетербургский институт ядерной физики им. Б. П. Константинова, Гатчина, Ленинградская Область, РФI. P. Pavlov First State Medical University, Saint-Petersburg, RFГосударственный медицинский университет им. акад. И. П. Павлова, Санкт-Петербург, РФI.I. Mechnikov State Medical Academy, St. Petersburg, RFСанкт-Петербургская государственная медицинская академия им. И.И. Мечникова, Санкт-Петербург, РФ1506201082VOL 8, NO2 (2010)ТОМ 8, №2 (2010)242814112016Copyright ©; 2010, Miroshnikova V.V., Rodygina T.I., Demina E.P., Kuryanov P.S., Urazgildeeva S.A., Gurevich V.S., Schwarzman A.L.Copyright ©; 2010, Мирошникова В.В., Родыгина Т.И., Демина Е.П., Курьянов П.С., Уразгильдеева С.А., Гуревич В.С., Шварцман А.Л.2010Miroshnikova V.V., Rodygina T.I., Demina E.P., Kuryanov P.S., Urazgildeeva S.A., Gurevich V.S., Schwarzman A.L.Мирошникова В.В., Родыгина Т.И., Демина Е.П., Курьянов П.С., Уразгильдеева С.А., Гуревич В.С., Шварцман А.Л.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/5389

Apoprotein A-1 is a major protein in antiaterogenic high density lipoproteins and it is one of key proteins regulating reverse cholesterol transport. In this study we have investigated association of APOA1 gene polymorphism with atherosclerosis development among Saint-Petersburg population. Allelic frequencies of polimorphic variants (-75)G/A and 83C/T of APOA1 gene were determined in the group of patients with angiographically proven aterosclerosis and in control group. Allele 83T of the APOA1 gene is associated with lower risk of atherosclerosis development among Saint-Petersburg population.

Апопротеин А-1 является основным белком антиатерогенных липопротеинов высокой плотности (ЛПВП ) и одним из ключевых белков обратного транспорта холестерина (ОТ Х). Целью данной работы явилось исследование ассоциации полиморфизма 5-регуляторной области гена APOA1 с развитием атеросклероза у жителей СанктПетербурга. Частоты полиморфных вариантов (-75)G/A и 83C/T были определены в группе пациентов с атеросклерозом, подтвержденным при ангиографическом исследовании, и в контрольной группе. Аллель 83Т гена APOA1 была асcоциирована со снижением относительного риска развития атеросклероза у жителей Санкт-Петербурга.

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