Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector540810.17816/ecogen3319-32ArticlesСтатьиResearch ArticleMolecular basis of applying antimutagens as anticarcinogensМОЛЕКУЛЯРНЫЕ ОСНОВЫ ПРИМЕНЕНИЯ АНТИМУТАГЕНОВ В КАЧЕСТВЕ АНТИКАНЦЕРОГЕНОВGoncharovaRoza IГончароваРоза ИосифовнаR.Goncharova@igc.bas-net.byKuzhirTatyana DКужирТатьяна ДановнаT.Kuzhir@igc.bas-net.byInstitute of Genetics and Cytology of the NASB, Minsk, Republic of BelarusИнститут генетики и цитологии НАНБ, Минск, Республика Беларусь1509200533VOL 3, NO3 (2005)ТОМ 3, №3 (2005)193214112016Copyright ©; 2005, Goncharova R.I., Kuzhir T.D.Copyright ©; 2005, Гончарова Р.И., Кужир Т.Д.2005Goncharova R.I., Kuzhir T.D.Гончарова Р.И., Кужир Т.Д.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/5408

The paper presents a review of current data on mechanisms of natural and synthetic antimutagen action underlying the expediency and availability of their application as anticarcinogens. Previously, some molecular processes involved in carcinogenesis as well as some therapeutic targets are considered. The effects of antimutagens on those or other molecular targets have been summarized in table. Along with the literature data on plant antimutagens, some experimental results and supposed mechanisms of the 1,4-dihydropyridine derivatives have been analyzed.

Представлен обзор современных данных по механизмам действия природных и синтетических антимутагенов, которые обосновывают целесообразность и перспективность их применения в качестве антиканцерогенов. Кратко охарактеризован канцерогенез, оценена роль наиболее важных для каждой из его стадий биологических процессов и выделены возможные молекулярные мишени терапевтического воздействия. Эффекты антимутагенов на те или иные молекулярные мишени суммированы в таблице. Наряду с данными об антимутагенах растительного происхождения, рассмотрены некоторые экспериментальные результаты и возможные молекулярные механизмы действия синтетических производных 1,4-дигидропиридина.

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