Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector543510.17816/ecogen8444-56ArticlesСтатьиResearch ArticleEpigenetical mechanisms of susceptibility to complex human diseasesЭПИГЕНЕТИЧЕСКИЕ МЕХАНИЗМЫ ПРЕДРАСПОЛОЖЕННОСТИ К КОМПЛЕКСНЫМ ПАТОЛОГИЯМ ЧЕЛОВЕКАPatkinEugene LПаткинЕвгений Львовичelp44@mail.ruQuinnJohnКвиннДжонJquinn@liv.ac.ukInstitute of Experimental Medicine, St. Petersburg, RFИнститут экспериментальной медицины, Санкт-Петербург, РФSchool of Biomedical Science, Medical School,University of Liverpool, Liverpool, UKШкола биомедицинских наук Университета Ливерпуля факультеты физиологии и клеточной биологии, Ливерпуль, Великобритания1512201084VOL 8, NO4 (2010)ТОМ 8, №4 (2010)445614112016Copyright ©; 2010, Patkin E.L., Quinn J.Copyright ©; 2010, Паткин Е.Л., Квинн Д.2010Patkin E.L., Quinn J.Паткин Е.Л., Квинн Д.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/5435

Contemporary data concerned an input of epigenetical mechanisms into an etiology and susceptibility to complex human diseases are critically analyzed. The special attention is attended to a specific role of simple tandem DNA repeats, the crucial role of developmental epigenetics in these processes. Patterns of mitotic and intergenerational inheritance of epigenetical modifications are considered.

В обзоре критически анализируются современные данные относительно участия эпигенетических механизмов в этиологии и предрасположенности к комплексным заболеваниям человека. Особое внимание уделено роли простых тандемных повторяющихся последовательностей ДНК , критической роли эпигенетики развития в данных процессах. Рассмотрены закономерности митотической и межпоколенческой передачи эпигенетических модификаций.

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