Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector554210.17816/ecogen6342-50ArticlesСтатьиResearch ArticleInfluence of mutations in regulatory PHO genes on stability of a genetic material of yeast Saccharomyces cerevisiaeВЛИЯНИЕ МУТАЦИЙ В РЕГУЛЯТОРНЫХ ГЕНАХ РНО НА СТАБИЛЬНОСТЬ ГЕНЕТИЧЕСКОГО МАТЕРИАЛА ДРОЖЖЕЙ SACCHAROMYCES CEREVISIAESmirnovArseny MСмирновАрсений Михайловичnusense@mail.ruSambukElena VСамбукЕлена Викторовнаesambuk@mail.ruSaint Petersburg State University, Saint-Petersburg, RFСанкт-Петербургский государственный университет, Санкт-Петербург, РФSaint-Petersburg State University, Saint-Petersburg, RFСанкт-Петербургский государственный университет, Санкт-Петербург, РФ1509200863VOL 6, NO3 (2008)ТОМ 6, №3 (2008)425014112016Copyright ©; 2008, Smirnov A.M., Sambuk E.V.Copyright ©; 2008, Смирнов А.М., Самбук Е.В.2008Smirnov A.M., Sambuk E.V.Смирнов А.М., Самбук Е.В.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/5542

Yeast Saccharomyces cerevisiae is convenient modelling object for studying of spontaneous mutations frequency under the influence of various environmental factors, and also as a result of metabolism infringement. One of necessary components of the growing media is inorganic phosphate. Its lack influences an expression of many genes. The system of genes expression regulation by phosphate is studied in detail. In the present work dependence of stability of a genetic material of a cage on its metabolic condition caused by mutations in genes, coding phosphate metabolism regulating proteins, is shown.

Дрожжи Saccharomyces cerevisiae являются удобным модельным объектом для изучения частоты возникновения спонтанных мутаций под воздействием различных факторов окружающей среды, а также в результате нарушения метаболизма. Одним из необходимых компонентов культуральной среды является неорганический фосфат. Его недостаток влияет на экспрессию многих генов. Система регуляции экспрессии генов фосфатом изучена подробно. В настоящей работе продемонстрирована зависимость стабильности генетического материала клетки от ее метаболического состояния, вызванного мутациями в генах, кодирующих регуляторные белки обмена фосфора.

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