Ecological geneticsEcological geneticsЭкологическая генетика1811-09322411-9202Eco-Vector574610.17816/ecogen9153-61ArticlesСтатьиResearch ArticleThe role of DNA polymerase alpha in the control of mutagenesis in Saccharomyces cerevisiae cells starved for nutrientsРоль ДНК-полимеразы альфа в контроле мугагенеза индуцированного голоданием у Saccharomyces cerevisiaeBabudriNoraБабудриНораbabudri@upihg.itAchilliAlessandroАчиллиАлессандроachilli@unipg.itMartinelliChiaraМартинеллиЧиараchiaramartinelli@hotmail.itMooreElizabethМурЭлизабетeamoore@unmc.eduLancioniHoviragЛансиониХовирагlancioni@kataweb.comPavlovYuri IПавловЮрий Ивановичypavlov@unmc.eduUniversity of Perugia, Perugia, ItalyУниверситет Перуджи, Перуджи, ИталияUniversity of Pavia, Pavia, ItalyУниверситет Павии, Павия, ИталияUniversity of Nebraska, Linkoln, NE, USAУниверситет штата Небраска, Линкольн, СШАEppley Institute for Research in Cancer and Allied Diseases, Omaha, NE, USAИнститут Эппли по изучению рака, Омаха, США1503201191VOL 9, NO1 (2011)ТОМ 9, №1 (2011)536118112016Copyright ©; 2011, Babudri N., Achilli A., Martinelli C., Moore E., Lancioni H., Pavlov Y.I.Copyright ©; 2011, Бабудри Н., Ачилли А., Мартинелли Ч., Мур Э., Лансиони Х., Павлов Ю.И.2011Babudri N., Achilli A., Martinelli C., Moore E., Lancioni H., Pavlov Y.I.Бабудри Н., Ачилли А., Мартинелли Ч., Мур Э., Лансиони Х., Павлов Ю.И.http://creativecommons.org/licenses/by/4.0https://journals.eco-vector.com/ecolgenet/article/view/5746

In nature, microorganisms experience numerous environmental stresses and generally grow poorly most of the time. In the last two decades it has become evident that mutations arise not only in actively dividing cells but also in nonreplicating or slowly replicating cells starved for nutrients. In yeast, precise base selection and proofreading by replicative DNA polymerases δ and ε keep starvation-associated mutagenesis (SAM) at basal levels. Less is known about the role of replicative DNA polymerase α (Pol α). Here we provide evidence that Pol α is involved in the control of SAM in yeast cells starved for adenine by participation in sporadic replication and/or DNA repair under these conditions. 

Микроогранизмы в естественных условиях большую часть времени растут медленно из-за стрессовых условий. За последние две декады стало ясно, что мутации возникают не только в активно делящихся клетках, но и в нереплицирующихся или медленно реплицирующихся клетках при голодании (мугагенез индуцированный голоданием, МИГ). Основными факторами, поддерживающими низкий базальный уровень МИГ являются способность ДНК-полимераз δ и ε точно подставлять нуклеотиды в ходе репликации и эндонуклеазная корректирующая активность этих ферментов. Гораздо меньше исследована роль репликативной ДНК-полимеразы α (Polα). В статье представлены аргументация в пользу того, что Polα вовлечена в контроль МИГ при голодании по аденину. Мы предполагаем, что в этих условиях Polα участвует в эпизодических актах репликации/репарации. 

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